Mandibular swelling as the initial presentation for renal cell carcinoma: A case report

An Older Woman Presenting with Jaw Pain and a Kidney Mass

“…The classic presenting symptoms are the triad of hematuria, flank pain, and a palpable abdominal mass (Grawitz triad) 1 ; however, this presentation only occurs in 10%–15% of patients with RCC. 2 This disease often presents at advanced stages with metastases 3 to the lung, bone, lymph nodes, adrenal glands, and brain. Metastases are believed to be driven by hematogenous or lymphatic spread.…”

“… 4 In total, 25%–30% of patients will have metastatic disease at the time of presentation. 2 RCC commonly spreads to orofacial soft tissues and sinuses; however, only 1% of patients with RCC demonstrate isolated head and neck metastases. 1 Breast, liver, and thyroid cancers are the most common cause of oral metastases in women.…”

Metastasis of Renal Cell Carcinoma to the Mandible

“…Metastasis to the head and neck region occurs in only 7.5% of RCC patients7 and is mainly seen in the thyroid, salivary gland, skull base, sinuses, pharynx, tonsils, tongue, lip, and skin 8. In particular, metastasis to the mandible is extremely rare with only a few reports 9–13. The clinical case report describes a case of RCC that metastasized to the mandible, in which the metastatic lesion in the oral cavity was found first, followed by the primary lesion.…”

“…8 In particular, metastasis to the mandible is extremely rare with only a few reports. [9][10][11][12][13] The clinical case report describes a case of RCC that metastasized to the mandible, in which the metastatic lesion in the oral cavity was found first, followed by the primary lesion.…”