Mandibular vascular hamartoma in a cat

Takagi, Satoshi; Kagawa, Yumiko; Hanazono, Kiwamu; Murakami, Shoko; Deguchi, Takao; Izumi, Yūsuke; Hosoya, Kenji; Kim, Sangho; Okumura, Masahiro

doi:10.1292/jvms.18-0148

Cited by 4 publications

(8 citation statements)

References 14 publications

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“…The imaging features in this case exhibit similarities with those described in a case report of a benign hamartoma in a cat (Takagi et al, 2018). Vascular hamartoma, a benign congenital lesion, originating from disorganized mature vascular cells (Smith et al, 2010).…”

Section: Introductionsupporting

confidence: 65%

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Imaging features of mandibular squamous cell carcinoma in a cat

Dekkers,

Kromhout,

Saunders

et al. 2024

Vlaams Diergeneeskundig Tijdschrift

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A fourteen-year-old, neutered, male European Shorthair cat was referred with clinical signs of anorexia, weight loss and right sided mandibular swelling, which progressively increased in size. In addition, marked thickening and ulceration of the ipsilateral mandibular gingiva were both found. A computed tomography scan revealed marked amorphous periosteal reaction, extensive cortical disruption, moth-eaten to permeative osteolysis and moderate surrounding soft tissue swelling. The histopathological diagnosis was a grade 2 squamous cell carcinoma with infiltration in the bone and separation of bony trabeculae.

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Section: Introductionsupporting

confidence: 65%

“…Vascular hamartoma, a benign congenital lesion, originating from disorganized mature vascular cells (Smith et al, 2010). The primary aim of this case report was to highlight the imaging characteristics of SCC in felines and to compare them with those of a benign hamartoma showing similar imaging features (Takagi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Imaging features of mandibular squamous cell carcinoma in a cat

Dekkers,

Kromhout,

Saunders

et al. 2024

Vlaams Diergeneeskundig Tijdschrift

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“…The link between abnormality and neoplasia is recognized due to disorganized overgrowth of vascular cells lining abnormal blood vessels and form a tumor-like mass [24]. In addition, the wide morphological variation of vascular hamartomas is considered a condition aiming to progress in a true neoplasia [17] Hamartomas are rarely reported in domestic animals and mostly are of vascular origin [1,6,15,16,24], and frequently present no predisposition of age, breed or gender [20]. However, Scottish Terrier and Airedale Terrier dog breeds are highlighted to present a predisposition to develop VH [28].…”

Section: Discussionmentioning

confidence: 99%

“…The up to 10 years old dog we are reporting here had never presented neurological signs. Some asymptomatic patients [3,8,12,24] or with a delayed onset of clinical signs [13] were reported in animals and humans with cerebral VH. Despite the multifocal VH in the brain tissues of the dog, possibly the anomalous vascular growth did not cause significant injury in the surrounding tissues to produce neurological impairment.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Vascular Hamartoma In a Campeiro Bulldog

Barros¹,

Gulgemin²,

Barreto³

et al. 2020

Acta Scientiae. Vet.

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Background: Vascular hamartomas (VH) are rare or simply underdiagnosed injuries in veterinary medicine and represent a non-neoplastic developmental anomaly disorganization and proliferation of endothelial tissue. VH occur in any region of the body, however in the brain present clinical relevance related with the potential for spontaneous bleeding, adjacent tissue compression and convulsive activity. The aim of these report is to describe clinical, pathological and immunohistochemical features of a case of cerebrovascular hamartoma and highlight the diagnosis of these rare brain disorder in dogs.Case: A 10-year-old male dog, a Campeiro Bulldog breed presented convulsions episodes and died before an elective surgical procedure for eyelid nodule removal. Three red nodules were observed in the brain, one between the parietal lobe and the left occipital lobe (in the medium suprasylviam sulcus), the other in the caudal region of the corpus callosum and the third one in the cerebellar cortex. Central nervous system, eyelids and most organs and tissues samples were collected, fixed in 10% formaldehyde and processed for histopathological analysis. Histologically, in the eyelid was detected a sebaceous adenoma. The nervous system samples revealed well-differentiated different sizes vascular structures with thin-walled and blood-filled, promoting compression of the brain. Normal neuropile was detected between the vascular structures substantiating cerebral vascular hamartoma diagnosis in the dog. Immunohistochemical assay was conducted with CD31 (monoclonal mouse antibody anti-CD31, Clone JC70A, Dako Corp.) and Von Willebrand factor (monoclonal mouse antibody anti-Von Willebrand factor, Clone F8/86, Dako Corp.) using the biotin–peroxidase–streptavidin method (PolyDetector Plus DAB–HRP, Bio SB) on CNS sections to confirm the vascular origin of the lining cells in the mass. Discussion: Hamartomas are rarely reported in domestic animals and mostly are of vascular origin. VH in nervous tissues can trigger clinical signs related to hemorrhage, brain space occupation, compression and obstructive secondary hydrocephalus. In general, cerebral VH have a slow progression and usually affected animals are asymptomatic. On the other hand, cerebral vascular hamartomas may also cause clinical signs in very young animals about 15 to 16 months old. In humans, clinical presentation of VH may be related with acquired lesions such as trauma, ionizing radiation, and other central nervous system injuries. In the present case, the dog presented convulsion episode only at 10 years old during pre-chirurgical procedures. The morphological features of the vascular hamartoma we observed in the Campeiro bulldog is classified as capillary teleangiectasia composed by well differentiated capillaries lined with well differentiated endothelial cells interspaced by normal neuronal tissue. Histopathological and immunohistochemical assay are extremely important to differentiate hamartoma from other tumors, since they may be macroscopically similar. The immunolabeling of endotelial cells by anti-CD31 and anti-Von Willebrand factor antibodies in the cerebral VH, highlight the vascular origin of the masses detected. However, it is also important to perform systematic gross examination of the brain in detail to detect even the smallest injuries in asymptomatic animals avoiding underdiagnoses of cerebral VH.

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“…Hamartomas are masses that consist of excessive growth of mature and normal tissues found in the area where the hamartoma is forming. Specifically, a vascular hamartoma is a benign and disorganized growth of vasculature tissue [1,2]. The benign nature of these tumors and their limited ability to grow indicate that these are more developmental lesions rather than true neoplasms, though they commonly resemble a neoplastic growth on gross examination.…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal Vascular Hamartoma in a Dog

Judy

Krebs

Haynes

et al. 2020

Case Reports in Veterinary Medicine

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An 8-year-old spayed female 32 kg Labrador retriever was presented for further investigation into the underlying cause of dyspnea, stertor, and sleep apnea present for three months and worsening over 30 days. There were significant reduction in airflow through the nares and loud inspiratory stridor. Thoracic and cervical radiographs made were normal. A skull CT and retrograde rhinoscopy showed a mass occluding the majority of the nasopharynx above the caudal third of the hard palate. The main differential diagnoses included a neoplastic mass vs. inflammatory mass vs. cyst vs. mucous obstruction. There was no destruction of nasal turbinates, making a benign etiology more likely. Biopsy of the mass showed an inflammatory process. En bloc excision of the mass was performed via ventral rhinotomy without complication. Histopathology of the excised mass revealed it to be a mucosal vascular hamartoma. The dog recovered uneventfully and had no further respiratory issues, short or long term. Although vascular hamartomas are a rare finding in veterinary medicine, they can be found in a wide variety of species and anatomic locations. They should be considered when naming differentials for benign mass lesions throughout the body, including the nasopharynx. Although they are benign masses in nature, they can be clinically significant and should be addressed. Prognosis after removal in this location is excellent.

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Mandibular vascular hamartoma in a cat

Cited by 4 publications

References 14 publications

Imaging features of mandibular squamous cell carcinoma in a cat

Imaging features of mandibular squamous cell carcinoma in a cat

Cerebral Vascular Hamartoma In a Campeiro Bulldog

Nasopharyngeal Vascular Hamartoma in a Dog

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