Objective: To identify the main reasons for early withdrawal of subdermal implant with etonogestrel after less than three years of use. Methods: Analytical cross-sectional study from January to December 2021, by stratified random sampling of 153 subdermal implant users of the Family Medicine Unit No. 80 in Morelia, Michoacán. The χ2 was used for frequency comparison; associations with sociodemographic data and main reasons for early withdrawal were reported, considering p<0.05 statistically significant. Results: The prevalent age group was 20-24 years with 75.8% (n= 116), the main reasons for early withdrawal of the subdermal implant were side effects 35.9% (n= 55), desire for pregnancy 19.6% (n= 30), medical recommendation 15.6% (n= 24), other reasons 15% (n= 23), performance of a definitive method such as bilateral tubal occlusion, and vasectomy by the partner 13.7% (n= 21). Subdermal implant withdrawal due to side effects, duration of use, marital status, and withdrawal due to desire for pregnancy were variables with statistically significant associations. Conclusions: The impact of side effects was the main reason for early withdrawal of the subdermal implant with etonogestrel.