Mangafodipir trisodium: Effects on T2- and T1-weighted MR cholangiography

Mitchell, Donald G.; Alam, Faiyaz

doi:10.1002/(sici)1522-2586(199902)9:2<366::aid-jmri33>3.0.co;2-e

Cited by 47 publications

(20 citation statements)

References 14 publications

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“…In patients in whom hepatobiliary excreted agents are used for the evaluation of primary disease, endoluminal views of the biliary tree can be obtained without extra cost. Mangafodipir trisodium is excreted through the biliary system having the potential to provide functional information resembling that of scintigraphy [15], but it might not be applied in patients with high bilirubin level. In the present feasibility study, evaluation of possible functional information provided by the technique was not performed due to the limited number of patients and lack of biliary pathology.…”

Section: Discussionmentioning

confidence: 99%

Development of contrast-enhanced virtual MR cholangioscopy: a feasibility study

et al. 2002

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The purpose of this study was to examine the feasibility of contrast-enhanced virtual MR cholangioscopy (CE VMRC). Intraluminal views of the extrahepatic biliary tree were generated in ten patients undergoing abdominal MRI post mangafodipir trisodium administration employing coronal 2.5-mm 3D fast low-angle shot (FLASH) images (TR 6.8 ms, TE 2.3 ms, matrix 195 x 512) with fat saturation and a commercially available software. Contrast-enhanced VMRC was compared with single-shot turbo spin-echo T2-weighted MR cholangiography (T2 MRC) in terms of ductal visualization and artifact presence, utilizing a five-point grading scale. Four anatomic segments were evaluated: the intra- and extra-pancreatic segment of the common bile duct (CBD), and the cystic duct and the area of hepatic duct bifurcation. Both CE VMRC and T2 MRC depicted 38 of 40 segments. There were no significant differences between CE VMRC and T2 MRC in ranking ductal segments visualization ( p=0.27). The high contrast between intraluminal fluid and extraluminal tissues facilitated the generation of endoscopic views. Contrast-enhanced virtual MR cholangioscopy is a feasible technique providing endoscopic views of the CBD. Initial results show correlation of CE VMRC with projectional MR cholangiography.

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Section: Discussionmentioning

confidence: 99%

Development of contrast-enhanced virtual MR cholangioscopy: a feasibility study

et al. 2002

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“…This conventional MR cholangiography (MRC) examination is highly accurate in detecting biliary tree disease [1,2]. However, the conventional MRC has diagnostic limitations, which include poor visualisation of the intrahepatic biliary tree compared with the extrahepatic biliary tree [3], limited spatial resolution and not being able to provide functional information of the biliary tree.Contrast-enhanced MRC has created interest in the field of MRC because of its potential to provide functional assessment and to improve the visualisation of the intrahepatic biliary trees [4][5][6]. The specific indications include pre-operative anatomical assessment of the biliary tree in preventing inadvertent complications in common laparoscopic cholecystectomy, and also in complex biliary surgical procedures such as biliary-enteric anastomosis and liver transplantation; post-operative assessment of the biliary tree after surgery when complications such as bile leak or inadvertent biliary tree stricture or ligation are suspected; and functional assessment of bile secretion and excretion [7][8][9].…”

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confidence: 99%

“…Contrast-enhanced MRC has created interest in the field of MRC because of its potential to provide functional assessment and to improve the visualisation of the intrahepatic biliary trees [4][5][6]. The specific indications include pre-operative anatomical assessment of the biliary tree in preventing inadvertent complications in common laparoscopic cholecystectomy, and also in complex biliary surgical procedures such as biliary-enteric anastomosis and liver transplantation; post-operative assessment of the biliary tree after surgery when complications such as bile leak or inadvertent biliary tree stricture or ligation are suspected; and functional assessment of bile secretion and excretion [7][8][9].…”

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confidence: 99%

“…We obtained serial images using both contrast agents, but no images were obtained more than 2 h after contrast administration. However, it has been reported that the optimal window for evaluating liver parenchyma and bile duct after injection is 15-20 min for Mn-DPDP contrast-enhanced MRC [4,5,22] and 20-30 min for Gd-EOB-DTPA contrast-enhanced MRC [12,[23][24][25]. We did not perform a qualitative analysis, and we did not evaluate whether differences in the SNRs and CNRs between the two contrast agents would affect clinical practice.…”

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confidence: 99%

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Contrast-enhanced MR cholangiography: comparison of Gd-EOB-DTPA and Mn-DPDP in healthy volunteers

Bae

Na²,

Ds³

et al. 2012

BJR

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Objective: The purpose of this study was to compare the biliary enhancement dynamics of gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid (Gd-EOB-DTPA) and mangafodipir trisodium (Mn-DPDP) for contrast-enhanced MR cholangiography (MRC) in healthy subjects. Methods: 15 healthy volunteers underwent MRI at 1.5 T with volumetric interpolated breath-hold examination sequence. Each volunteer was scanned once for each contrast agent. The signal-to-noise ratio (SNR) of the liver parenchyma and common hepatic duct (CHD) and the contrast-to-noise ratio (CNR) of CHD to liver parenchyma were evaluated and compared before and at several time points (5,15, 30, 45, 60, 90, and 120 min) after injection of each agent. Results: SNR was significantly higher for Gd-EOB-DTPA than for Mn-DPDP in liver parenchyma after 5 min and in CHD after 15 min (p,0.05). CNR of CHD to liver parenchyma using Gd-EOB-DTPA showed an initial decrease at 5 min post-injection followed by a steep increase to a peak at 15 min post-injection. CNR using Mn-DPDP showed a steady increase to a peak at 15 min post-injection without an initial decrease. At 15 min, the value of CNR was significantly higher for Gd-EOB-DTPA than for Mn-DPDP (p,0.05). Conclusion: For both contrast agents, CNR reached a peak at 15 min after contrast injection. At this time point, CNR of Gd-EOB-DTPA was significantly higher than that of Mn-DPDP. Therefore, Gd-EOB-DTPA may provide better contrast-enhanced MRC than Mn-DPDP at 15 min after contrast administration. The bile ducts are generally studied using fast spin echo T 2 weighted sequences with half-Fourier reconstruction. This conventional MR cholangiography (MRC) examination is highly accurate in detecting biliary tree disease [1,2]. However, the conventional MRC has diagnostic limitations, which include poor visualisation of the intrahepatic biliary tree compared with the extrahepatic biliary tree [3], limited spatial resolution and not being able to provide functional information of the biliary tree.Contrast-enhanced MRC has created interest in the field of MRC because of its potential to provide functional assessment and to improve the visualisation of the intrahepatic biliary trees [4][5][6]. The specific indications include pre-operative anatomical assessment of the biliary tree in preventing inadvertent complications in common laparoscopic cholecystectomy, and also in complex biliary surgical procedures such as biliary-enteric anastomosis and liver transplantation; post-operative assessment of the biliary tree after surgery when complications such as bile leak or inadvertent biliary tree stricture or ligation are suspected; and functional assessment of bile secretion and excretion [7][8][9].Contrast-enhanced MRC is performed with hepatobiliary MR contrast agents such as mangafodipir trisodium (Mn-DPDP), gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic-acid (Gd-EOB-DPTA) or gadobenate dimeglumine (Gd-BOPTA), which are administered intravenously, taken up by the hepatocytes, and then excreted via the biliary syste...

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“…MANGAFODIPIR TRISODIUM (Mn-DPDP, Teslascan) is a hepatobiliary magnetic resonance (MR) contrast agent that is administered intravenously, taken up by the liver, and transported to bile, where it causes T1 shortening as a result of the paramagnetic effects of its bound manganese ion (1)(2)(3). Because it is excreted primarily via the biliary system, Mn-DPDP-enhanced MR imaging (MRI) is suitable as a functional MR cholangiogram (fMRC) (4), to provide a functional assessment of the hepatobiliary system.…”

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confidence: 99%

Functional magnetic resonance cholangiography (fMRC) of the gallbladder and biliary tree with contrast‐enhanced magnetic resonance cholangiography

Fayad

Holland

Bergin

et al. 2003

Magnetic Resonance Imaging

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Purpose:To determine the diagnostic performance of functional magnetic resonance cholangiography (fMRC) for the evaluation of anatomic and functional biliary disorders.Materials and Methods: At 1.5 T, 39 MR examinations with conventional MRC and mangafodipir trisodium-enhanced fMRC were retrospectively reviewed by three observers who recorded anatomic (duct dilation, stricture, filling defects) and functional (cholecystitis, obstruction) abnormalities in three modes: MRC alone, fMRC alone, and MRC and fMRC images together (combined-MRC). Performance was determined by comparing findings with each mode to findings of invasive cholangiography (IC) and surgery.Results: Among 75 biliary segments (correlated with IC), the sensitivity/specificity for diagnosing dilation (N ϭ 41) with MRC was 95%/97%; with fMRC, 90%/100%; with combined-MRC, 100%/97%. For stricture (N ϭ 7), the sensitivity/specificity of MRC was 86%/98%; of fMRC, 43%/100%; of combined-MRC, 86%/100%. For filling defects (N ϭ 9), the sensitivity/specificity of MRC was 91%/98%; of fMRC, 82%/ 100%; of combined-MRC, 91%/100%. For diagnosing obstruction (N ϭ 9), the sensitivity/specificity of MRC, fMRC, and combined-MRC were 89%/100%, 100%/100%, and 100%/100%, respectively. For surgically proven cholecystitis (N ϭ 13), positive predictive values for diagnosing acute/ chronic cholecystitis for MRC were 33%/40%; for fMRC, 100%/50%; for combined-MRC, 100%/50%. Conclusion:Although single-shot fast spin echo (SSFSE)-MRC is valuable, the addition of fMRC increased diagnostic performance for functional biliary disorders.

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Mangafodipir trisodium: Effects on T2- and T1-weighted MR cholangiography

Cited by 47 publications

References 14 publications

Development of contrast-enhanced virtual MR cholangioscopy: a feasibility study

Development of contrast-enhanced virtual MR cholangioscopy: a feasibility study

Contrast-enhanced MR cholangiography: comparison of Gd-EOB-DTPA and Mn-DPDP in healthy volunteers

Functional magnetic resonance cholangiography (fMRC) of the gallbladder and biliary tree with contrast‐enhanced magnetic resonance cholangiography

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