Manganese

Lucchini, Roberto; Aschner, Michael; Kim, Yangho

doi:10.1016/b978-0-12-822946-0.00019-2

Cited by 6 publications

(10 citation statements)

References 401 publications

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“…As a result of the efficient homeostatic control of manganese body content, the association between external and internal exposure indicators at the individual level is weak (Lucchini et al., 2022). Normal concentrations of manganese in blood show a wide range (4–15 μg/L; Section 3.2.2), with relatively higher concentrations found among women versus men (Section 3.2.4.1), during infancy versus later in life (Section 3.2.4.2), and among pregnant women versus non‐pregnant women (Section 3.2.4.3).…”

Section: Assessmentmentioning

confidence: 99%

“…Blood manganese concentration has been shown to be a useful indicator of exposure on a group basis in the context of occupational exposure (i.e. to distinguish exposed vs. unexposed workers); however, the individual measurements of blood manganese do not correspond to individual external exposure levels (Lucchini et al., 2022; Zheng et al., 2011). Blood/serum/plasma manganese levels become relevant in cases of very high exposure, in which case they may be useful to identify individuals with excess manganese intake (Section 3.4.1.7).…”

Section: Assessmentmentioning

confidence: 99%

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Scientific opinion on the tolerable upper intake level for manganese

Turck,

Bohn,

Castenmiller

et al. 2023

EFS2

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Following a request from the European Commission (EC), the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the tolerable upper intake level (UL) for manganese. Systematic reviews of the literature of human and animal data were conducted to assess evidence regarding excess manganese intake (including authorised manganese salts) and the priority adverse health effect, i.e. manganese-induced neurotoxicity. Available human and animal studies support neurotoxicity as a critical effect, however, data are not sufficient and suitable to characterise a dose-response relationship and identify a reference point for manganese-induced neurotoxicity. In the absence of adequate data to establish an UL, estimated background dietary intakes (i.e. manganese intakes from natural dietary sources only) observed among high consumers (95th percentile) were used to provide an indication of the highest level of intake where there is reasonable confidence on the absence of adverse effects. A safe level of intake of 8 mg/day was established for adults ≥ 18 years (including pregnant and lactating women) and ranged between 2 and 7 mg/day for other population groups. The application of the safe level of intake is more limited than an UL because the intake level at which the risk of adverse effects starts to increase is not defined. K E Y W O R D Smanganese, safe level of intake, tolerable upper intake level, UL

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Section: Assessmentmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

Scientific opinion on the tolerable upper intake level for manganese

Turck,

Bohn,

Castenmiller

et al. 2023

EFS2

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“…Manganese is an important trace metal element for the human body 28 and is widely distributed in the environment. 29 Manganese ions (Mn 2+ ) have special biochemical and physiological functions as they are essential for the activity of various enzymes (e.g., arginase and glutamine synthase). 30 However, it has been reported that elevated Mn 2+ concentrations may result in aberrant neurological symptoms.…”

Section: Introductionmentioning

confidence: 99%

Manganese Ion-Induced Amyloid Fibrillation Kinetics of Hen Egg White-Lysozyme in Thermal and Acidic Conditions

Chen

Xing

et al. 2023

ACS Omega

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As manganese ions (Mn 2+ ) are identified as an environmental risk factor for neurodegenerative diseases, uncovering their action mechanism on protein amyloid fibril formation is crucial for related disease treatments. Herein, we performed a combined study of Raman spectroscopy, atomic force microscopy (AFM), thioflavin T (ThT) fluorescence, and UV–vis absorption spectroscopy assays, in which the distinctive effect of Mn 2+ on the amyloid fibrillation kinetics of hen egg white-lysozyme (HEWL) was clarified at the molecular level. With thermal and acid treatments, the unfolding of protein tertiary structures is efficiently accelerated by Mn 2+ to form oligomers, as indicated by two Raman markers for the Trp residues on protein side chains: the FWHM at 759 cm –1 and the I 1340 / I 1360 ratio. Meanwhile, the inconsistent evolutionary kinetics of the two indicators, as well as AFM images and UV–vis absorption spectroscopy assays, validate the tendency of Mn 2+ toward the formation of amorphous aggregates instead of amyloid fibrils. Moreover, Mn 2+ plays an accelerator role in the secondary structure transition from α-helix to organized β-sheet structures, as indicated by the N–C α -C intensity at 933 cm –1 and the amide I position of Raman spectroscopy and ThT fluorescence assays. Notably, the more significant promotion effect of Mn 2+ on the formation of amorphous aggregates provides credible clues to understand the fact that excess exposure to manganese is associated with neurological diseases .

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“…Manganese (Mn) is an essential element for living organisms, including humans. It is a required cofactor for many enzymes that have critical functions in diverse processes such as forming cartilage and bone, excreting waste via the urea cycle, maintaining mitochondria, antioxidant defenses, producing glucose, brain development, and wound healing [ 1 ]. Humans mainly get Mn from dietary intake and Mn deficiency is very rare.…”

Section: Introductionmentioning

confidence: 99%

“…Mn exposure was first associated with adverse health outcomes in adults, including Mn-induced Parkinsonism and other neurodegenerative conditions, due to occupational exposures from mining, battery production, welding, and ferromanganese alloy plants [ 2 , 4 , 5 ]. Environmental Mn exposure has become a public health concern in recent years due to emerging evidence that children may be exposed to harmful levels of Mn from multiple sources, including drinking water, soil and dust, and possibly their diet [ 1 ]. Epidemiological studies have shown that elevated Mn exposure is associated with reductions in full scale IQ, along with adverse behavior and fine motor function in children and adolescents [ 6 – 9 ]; however, others have found no adverse association [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Genetics and Epigenetics of Manganese Toxicity

Lindner

Lucchini

Broberg

2022

Curr Envir Health Rpt

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Purpose of Review At elevated levels, the essential element manganese (Mn) is neurotoxic and increasing evidence indicates that environmental Mn exposure early in life negatively affects neurodevelopment. In this review, we describe how underlying genetics may confer susceptibility to elevated Mn concentrations and how the epigenetic effects of Mn may explain the association between Mn exposure early in life and its toxic effects later in life. Recent Findings Common polymorphisms in the Mn transporter genes SLC30A10 and SLC39A8 seem to have a large impact on intracellular Mn levels and, in turn, neurotoxicity. Genetic variation in iron regulatory genes may to lesser extent also influence Mn levels and toxicity. Recent studies on Mn and epigenetic mechanisms indicate that Mn-related changes in DNA methylation occur early in life. One human and two animal studies found persistent changes from in utero exposure to Mn but whether these changes have functional effects remains unknown. Summary Genetics seems to play a major role in susceptibility to Mn toxicity and should therefore be considered in risk assessment. Mn appears to interfere with epigenetic processes, potentially leading to persistent changes in developmental programming, which warrants further study.

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Manganese

Cited by 6 publications

References 401 publications

Scientific opinion on the tolerable upper intake level for manganese

Scientific opinion on the tolerable upper intake level for manganese

Manganese Ion-Induced Amyloid Fibrillation Kinetics of Hen Egg White-Lysozyme in Thermal and Acidic Conditions

Genetics and Epigenetics of Manganese Toxicity

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