Manganese and lead levels in settled dust in elementary schools are correlated with biomarkers of exposure in school-aged children

Rodrigues, Juliana Lima Gomes; Bandeira, Matheus J.; Araújo, Cecília F.S.; Santos, Nathália R. dos; Anjos, Ana Laura S; Koin, Ng Lai; Pereira, Laiz C.; Oliveira, Sönia Sales de; Mergler, Donna; Menezes-Filho, José A.

doi:10.1016/j.envpol.2017.10.132

Cited by 29 publications

(17 citation statements)

References 40 publications

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“…Positive correlations have been documented between concentration in toenails, urine, and blood in the case of Mn [75] which, in the present study, has been found in higher concentration in exposed children than in controls. Of note, positive correlations have been demonstrated between the concentrations of metals in toenails and in environmental matrices such as dust [61,71,76,77], soil [61,63,77,78], and water [63,79], confirming the adequacy of toenail as a biomarker of environmental exposure.…”

Section: Discussionmentioning

confidence: 78%

“…The slow rate of growth of toenails (on average 1.62 mm/month) [37] allows to evaluate longer term exposure [37], as compared with blood or urine [38][39][40]. Few studies evaluated the correlation between the concentration of metals in nails and in other biological matrices, with variable results [40] probably due to the different time windows that can be explored using nails (6-12 months earlier [37,40,67,71,72]), blood (2-3 h [73]), and urine (3-4 days [74]). Positive correlations have been documented between concentration in toenails, urine, and blood in the case of Mn [75] which, in the present study, has been found in higher concentration in exposed children than in controls.…”

Section: Discussionmentioning

confidence: 99%

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Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Ciaula

Gentilini²,

Diella

et al. 2020

IJERPH

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The impact of waste incinerators is usually examined by measuring environmental pollutants. Biomonitoring has been limited, until now, to few metals and to adults. We explored accumulation of a comprehensive panel of metals in children free-living in an urban area hosting two waste incinerators. Children were divided by georeferentiation in exposed and control groups, and toenail concentrations of 23 metals were thereafter assessed. The percentage of children having toenail metal concentrations above the limit of detection was higher in exposed children than in controls for Al, Ba, Mn, Cu, and V. Exposed children had higher absolute concentrations of Ba, Mn, Cu, and V, as compared with those living in the reference area. The Tobit regression identified living in the exposed area as a significant predictor of Ba, Ni, Cu, Mn, and V concentrations, after adjusting for covariates. The concentrations of Ba, Mn, Ni, and Cu correlated with each other, suggesting a possible common source of emission. Exposure to emissions derived from waste incinerators in an urban setting can lead to body accumulation of specific metals in children. Toenail metal concentration should be considered a noninvasive and adequate biomonitoring tool and an early warning indicator which should integrate the environmental monitoring of pollutants.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Ciaula

Gentilini²,

Diella

et al. 2020

IJERPH

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“…Hair and toenail sample collection and analysis are described in detail in our previous report [ 33 ]. Briefly, hair was cut as close to the scalp from the occipital region and all toenails were clipped from both feet using a stainless-steel nail clipper.…”

Section: Methodsmentioning

confidence: 99%

“…Previously, we have demonstrated that children who attended elementary schools with high Mn dust deposition rates due to the emissions from the ferro-manganese alloy plant presented higher levels of Mn measured in hair and toenails [ 33 ]. However, Pb dust deposition rates were not related with the proximity to that plant, but more associated with the vicinity of the schools to high traffic roads.…”

Section: Introductionmentioning

confidence: 99%

Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children

Menezes-Filho

Carvalho

Rodrigues

et al. 2018

IJERPH

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Studies have demonstrated that, for urban children, dust represents the main exposure to sources of metals like lead (Pb) and manganese (Mn). We aimed to investigate the exposure to these metals and their association with intellectual deficit in children living in an industrial region. This cross-sectional study recruited volunteers from four elementary schools in the town of Simões Filho, Brazil. We evaluated 225 school-aged children (7–12 years) for blood lead (PbB) and manganese hair (MnH) and toenails (MnTn) by graphite furnace atomic absorption spectrometry. Child and maternal IQs were estimated using the Wechsler Abbreviated Scale for Intelligence (WASI). Median and range PbB were 1.2 (0.3–15.6) μg/dL. MnH and MnTn medians (ranges) were 0.74 (0.16–8.79) μg/g and 0.85 (0.15–13.30) μg/g, respectively. After adjusting for maternal IQ, age and Mn exposure, child IQ drops by 8.6 points for a 10-fold increase in PbB levels. Moreover, an effect modification of Mn co-exposure was observed. In children with low MnTn, association between Pb and child IQ was not significant (β = −6.780, p = 0.172). However, in those with high MnTn, the association was increased by 27.9% (β = −8.70, p = 0.036). Low Pb exposure is associated with intellectual deficit in children, especially in those with high MnTn.

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“…It is easy to sample and manipulate, and it reflects the potential risk of population exposure. 11,12 Mn in street dust can be estimated as concentration (mg/ kg), as load per area unit (mg/m 2 ) or as rate load (mg/ m 2 /30 days). All these measurements turn up important information.…”

Section: Introductionmentioning

confidence: 99%

Spatial distribution of manganese concentration and load in street dust in Mexico City

et al. 2020

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Objective. To obtain a first indication of the distribution and extent of manganese (Mn) contamination in Mexico City. Mn concentration and load in street dust were analyzed in order to reveal the most contaminated areas. Materials and methods. 482 samples of street dust were analyzed through inductively coupled plasma-optical emission spectroscopy. The contamination factor (CF), the geoaccumulation index (Igeo) and the spatial interpolations of the kriging indicator were calculated. Results. A slight influence of anthropogenic activities is detected on the Mn content of street dust. The highest levels of pollution by concentration (Igeo=uncontaminated to moderately contaminated) are grouped towards the city’s north (industrial) and center (commercial and high traffic) areas. The areas with the highest Mn load were located towards the east and northwest areas (Igeo=moderately contaminated). Conclusions. These findings will serve as a baseline to assess future variations in Mn content in Mexico City’s environment.

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Manganese and lead levels in settled dust in elementary schools are correlated with biomarkers of exposure in school-aged children

Cited by 29 publications

References 40 publications

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children

Spatial distribution of manganese concentration and load in street dust in Mexico City

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