Manganese and Lipoflavonoid Plus® to Treat Tinnitus: A Randomized Controlled Trial

Rojas-Roncancio, Eveling; Tyler, Richard S.; Jun, Hyung-Jin; Wang, Tang-Chuan; Ji, Haihong; Coelho, Cláudia; Witt, Shelley; Hansen, Marlan R.; Gantz, Bruce J.

doi:10.3766/jaaa.15106

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…TPFQ was utilized in a clinical trial to measure the severity and outcomes of tinnitus. [57] However, a comparison between TPFQ and THQ in the original study of TPFQ (Tyler et al, 2014), instead of THI, may have narrowed the coverage of TFPQ. For this purpose, we estimated the convergent validity of TPFQ-M compared to THI-M, which has been extensively utilized in China.…”

Section: Discussionmentioning

confidence: 99%

Reliability and validity of the mandarin version of the tinnitus primary function questionnaire

Lü

Liu

et al. 2019

Medicine

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Tinnitus is a prevalent condition among different populations. As the nature of tinnitus is subjective, self-reported measures have been validated and utilized to assess psychometric properties of tinnitus patients. Without exception, Chinese clinicians have administered these measures to patients in mainland China after cross-cultural adaptation. However, shortcomings of these Mandarin measures limited the widespread use of them. Measures which can be fully adapted to the context of Chinese tinnitus patients are still needed. The objective of this study was to evaluate the reliability and validity of the Mandarin Tinnitus Primary Function Questionnaire (TPFQ-M) in a Chinese population. In this observational questionnaire study, we recruited 350 subjects with primary tinnitus from hearing clinics of West China Hospital and administered the TPFQ-M, Mandarin Tinnitus Handicap Inventory (THI-M), and a systematic hearing test battery. The subjects finished the TPFQ-M within 3 minutes. Exploratory and confirmatory factor analyses demonstrated that a 4-factor model was close to fit. The Cronbach alpha of TPFQ-M was 0.925, and test-retest reliability was reasonable with a 7-day test interval (ICC = 0.857, P < .001; 95% CI: 0.764–0.915). Test-retest reliabilities of subdomains were not parallel to each other, with 0.612 for Emotion, 0.766 for Sleep, 0.860 for Concentration, and 0.897 for Hearing. The convergent validity of TPFQ-M compared to the THI-M was moderate ( r = 0.705, P < .001; 95% CI: 0.647–0.754). The TPFQ-M, which shows high internal consistency and good factor structure, is simple and relatively easy to administer in busy clinics. Additional in-depth research involving multiple centers in mainland China is warranted.

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Section: Discussionmentioning

confidence: 99%

Reliability and validity of the mandarin version of the tinnitus primary function questionnaire

Lü

Liu

et al. 2019

Medicine

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“…Acupuncture and electromagnetic stimulation have also been attempted. Dietary supplements are used extensively in the treatment of tinnitus, including gingko biloba, lipo-flavonoids, manganese, magnesium, melatonin, vitamin B12, and zinc [ 65 , 66 ].…”

Section: Current Treatment Methodsmentioning

confidence: 99%

Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention

et al. 2020

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Long-term noise exposure often results in noise induced hearing loss (NIHL). Tinnitus, the generation of phantom sounds, can also result from noise exposure, although understanding of its underlying mechanisms are limited. Recent studies, however, are shedding light on the neural processes involved in NIHL and tinnitus, leading to potential new and innovative treatments. This review focuses on the assessment of NIHL, available treatments, and development of new pharmacologic and non-pharmacologic treatments based on recent studies of central auditory plasticity and adaptive changes in hearing. We discuss the mechanisms and maladaptive plasticity of NIHL, neuronal aspects of tinnitus triggers, and mechanisms such as tinnitus-associated neural changes at the cochlear nucleus underlying the generation of tinnitus after noise-induced deafferentation. We include observations from recent studies, including our own studies on associated risks and emerging treatments for tinnitus. Increasing knowledge of neural plasticity and adaptive changes in the central auditory system suggest that NIHL is preventable and transient abnormalities may be reversable, although ongoing research in assessment and early detection of hearing difficulties is still urgently needed. Since no treatment can yet reverse noise-related damage completely, preventative strategies and increased awareness of hearing health are essential.

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“…Gabby indicated she received advice limited to the recommendation of over-the-counter Lipoflavinoids, in addition to being told "there was nothing [she] can do about it." 10,11 The patient denied subjective improvements in tinnitus perception following a 3-month intake of Lipoflavinoids.…”

Section: Tinnitus Historymentioning

confidence: 99%

Tinnitus Management: The Utilization of a Hybrid Telehealth and In-Person Delivery Model

Scaglione

Kuzbyt

2021

Semin Hear

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Telehealth, or the delivery of healthcare services from a distance, has historically been used to provide care to underserved populations and to those unable to visit a healthcare center. During the ongoing global COVID-19 pandemic, some providers of tinnitus healthcare services incorporated telehealth into their clinical protocols to allow for continued care for their patients while adhering to social distancing guidelines and safety measures. Bothersome tinnitus can negatively impact one's quality of life. Telehealth has been instrumental in treating this debilitating problem in a time when in-person care has not been easily available. The case of a patient with tinnitus is examined to demonstrate the use of a hybrid delivery model utilizing telehealth and in-person interactions to assess and manage her bothersome tinnitus. In-person services were used for audiological assessments and fitting of treatment devices, while telehealth was utilized for counseling, education, and remote programming of her treatment devices. This combined approach, which has allowed the patient to continue receiving care safely during the pandemic, can be continued for future care. Telehealth offers several advantages to patients and providers alike. While the COVID-19 pandemic will hopefully come to an end, telehealth services for tinnitus management may be here to stay.

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Manganese and Lipoflavonoid Plus® to Treat Tinnitus: A Randomized Controlled Trial

Abstract: We were not able to conclude that either manganese or Lipoflavonoid Plus(®) is an effective treatment for tinnitus.

Cited by 7 publications

References 15 publications

Reliability and validity of the mandarin version of the tinnitus primary function questionnaire

Reliability and validity of the mandarin version of the tinnitus primary function questionnaire

Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention

Tinnitus Management: The Utilization of a Hybrid Telehealth and In-Person Delivery Model

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