Manganese-Catalyzed Carbonylation of Unactivated Alkyl Bromides with Alkylidenecyclopropanes

Abstract

The transition-metal-catalyzed carbonylation reaction has emerged as a powerful method for the construction of carbonyl compounds. However, very few examples have worked for the carbonylative coupling of organic halides with alkenes. We report herein the Mn-catalyzed carbonylation of unactivated alkyl bromides with alkylidenecyclopropanes. It represents the rare progress on the Mn-catalyzed carbonylation of alkyl bromides with a carbon nucleophile. A broad range of primary and secondary alkyl bromides reacted smoothly with ACPs to afford 1,2dihydronaphthalene derivatives in good yields. The broad applicability of this protocol was further highlighted by the latestage modification of several natural products and pharmaceuticals.