Manganese complex [Mn(CO)3(tpa-κ3N)]Br increases antibiotic sensitivity in multidrug resistant Streptococcus pneumoniae

Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions have a long history of antimicrobial activity and have received increasing attention in recent years owing to the rise of antimicrobial resistance. The search for antibacterial agents now encompasses metal ions, nanoparticles and metal complexes with antimicrobial activity (‘metalloantibiotics’). Although yet to be advanced to the clinic, metalloantibiotics are a vast and underexplored group of compounds that could lead to a much-needed new class of antibiotics. This Review summarizes recent developments in this growing field, focusing on advances in the development of metalloantibiotics, in particular, those for which the mechanism of action has been investigated. We also provide an overview of alternative uses of metal complexes to combat bacterial infections, including antimicrobial photodynamic therapy and radionuclide diagnosis of bacterial infections.

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“…The repeated occurrence of the M(CO) 3 fragment (M = Mn (refs. 176,[183][184][185][186][187] ), Re (refs. 174,175,188,189 ) and W (ref.…”

Section: Antibacterial Activity Of Metal Complexesmentioning

confidence: 99%

Metals to combat antimicrobial resistance

et al. 2023

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Metal Complexes as Resistance Breakers or Metalloantibiotics for Combating Antimicrobial Resistance

Li¹,

Sun²

2022

Encyclopedia of Inorganic and Bioinorganic Chemistry

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The rapid emergence and spread of antimicrobial resistant (AMR) bacterial strains post significant threats to public health globally. Owing to the complexity of AMR, different strategies have been proposed, among which metal‐based strategy has receiving growing attention. Metallodrugs/ metal‐based complexes often exert multi‐targeted mode of action, thus having less likelihood to evolve resistance. Moreover, metal complexes could also target resistant enzymes produced by bacteria, thus might serve as antibiotic adjuvants for rescuing currently used antibiotics. In this encyclopaedia, we summarize the metal‐based strategy for combating AMR including both as resistance breakers or metalloantibiotics. Their underlying mechanisms of actions are also included. We also discuss the future perspective, opportunity and challenges in the field.

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