Manganese complex [Mn(CO)₃(tpa-κ³N)]Br increases antibiotic sensitivity in multidrug resistantStreptococcus pneumoniae

Abstract

<jats:title>Abstract</jats:title><jats:p>The emergence of multidrug-resistance (MDR) in <jats:italic>Streptococcus pneumoniae</jats:italic> clones and non-vaccine serotypes is of increasing concern, necessitating the development of novel treatment strategies. Here, we determined the efficacy of the Mn complex [Mn(CO)<jats:sub>3</jats:sub>(tpa-κ<jats:sup>3</jats:sup>N)]Br against MDR <jats:italic>S. pneumoniae</jats:italic> strains. Our data showed that [Mn(CO)<jats:sub>3</jats:sub>(tpa-κ<jats:sup>3</jats:sup><jats:italic>N</jats:italic>)]Br has <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> antibacterial activity and has the potential to be used in combination with currently available antibiotics to increase their effectiveness against MDR <jats:italic>S. pneumoniae</jats:italic>.</jats:p>