Manganese complexes and manganese-based metal-organic frameworks as contrast agents in MRI and chemotherapeutics agents: Applications and prospects

Preparation of nanoscale cationic metal–organic framework Nano Mn(iii)-TP for theranostics based on valence changes

“…18,34,35 Therefore, as an excellent carrier capable of carrying drug molecules and inducing a Fenton reaction by valence changes of its metal ions, nano MOF has broad application prospects in the biomedical field. 36,37 Magnetic resonance imaging (MRI) is a diagnostic tool for anatomical tissue imaging in medical science by monitoring the difference in the relaxation rate (1/T 1 = the longitudinal relaxation rate and 1/T 2 = the transverse relaxation rate) of water particles existing in tissues, based on NMR principles. Higher relaxation rates at the same concentration provide better contrast images, and T 1 -weighted images are often used to assess the anatomical structures at specific sites, while T 2 -weighted images are utilized to monitor tissue lesions.…”

Molybdenum‐Based Nanomaterials for Photothermal Cancer Therapy

“…[215] Since then, CDT has gradually become a new strategy of cancer treatment using transition metal ions as catalysts to produce ROS under TME to induce cancer cell death. [216][217][218][219] However, the CDT performance is greatly restricted by the weak acidity in tumor tissues as well as the low concentration of H 10A). [136] After modifying with BSA, the FeO/ MoS 10B).…”

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

“…Similar to other paramagnetic contrast materials, Mn-based NCAs can shorten the T 1 value of water protons, thereby enhancing the signal intensity of T 1 weighted in MRI; Mn also displayed some important intrinsic properties such as labile water exchange, high spin number, and long electronic relaxation time. , Notably, Mn-based NCAs with minor T 2 effects could reduce the signal intensity to obtain dark signals . In one study, a biocompatible nanosystem was constructed from Mn, carbon quantum dot, and SiO 2 as the nanoprobe with nontoxicity on HEK-293 cell lines, and its relaxivity was higher than that of conventional Gd-based contrast agents .…”

“…Designed novel (nano)­structures with unique features can be used as suitable platforms for imaging/diagnostic purposes. For instance, MOF-based structures have been explored as NCAs for MRI purposes (as single T 1 or T 2 contrast agent or in T 1 / T 2 combined form), and their efficiency basically depends on the surface modification deploying functional groups that improve their stability and biosafety. , Functional MOF-based NCAs have been constructed with high stability toward the aggregations to avoid simple breakdown or destruction in the biological environments . Their specificity/selectivity, targeting properties, and cell imaging potentials have also been greatly improved.…”