Manganese concentrations in maternal and umbilical cord blood: related to birth size and environmental factors

Guan, Huai; Wang, Man; Li, Xiaowei; Piao, Fengyuan; Li, Qiujuan; Xu, Lei; Kitamura, Fumihiko; Yokoyama, Kazuhito

doi:10.1093/eurpub/ckt033

Cited by 54 publications

(48 citation statements)

References 31 publications

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“…However, these concentrations were much lower than those reported in comparable studies from China (mean 55 µg/L) and France (mean 23 µg/L) 31,32 . Mn levels at different stages of pregnancy were not reported in the current study.…”

Section: Discussioncontrasting

confidence: 76%

Prenatal exposure to manganese in South African coastal communities

Röllin

Kootbodien

Theodorou

et al. 2014

Environ. Sci.: Processes Impacts

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Exposure to environmental sources and altered physiological processes of manganese uptake during pregnancy and its possible effect on prenatal and postnatal development are of concern. This study investigates manganese blood levels at the time of delivery across four cohorts of pregnant women residing in coastal communities of South Africa and examines birth outcomes and environmental factors that could influence manganese levels in the study population. The geometric mean (GM) manganese blood levels (MnB) for all women at delivery was 15.2 µg/L. Collectively, rural women reported higher MnB concentrations (GM, 16.1 µg/L) than urban women (GM, 13.5 µg/L, p<0.001). Of the 302 cord blood samples drawn from the study participants (rural women only), GM MnB levels reported for three rural sites were 25.8 µg/L (Rural 1), 33.4 µg/L (Rural 2) and 43.0 µg/L (Rural 3) and were twice as high as their respective maternal levels. However, no significant correlations were found between maternal and cord MnB levels across the 3 study areas. Factors associated 2 with elevated maternal MnB levels, after adjusting for gestational age were: women living in a rural area (Rural 2) (p = 0.021); women drinking potable water from an outdoor/communal tap sourced from municipality (p = 0.021); drinking water from river/stream (p = 0.036); younger maternal age (p = 0.026); consuming leafy vegetables once a week (p = 0.034); and elevated maternal blood lead concentrations (PbB) (p = 0.002). The results indicate that a MnB concentration in rural women during pregnancy is higher compared to urban women and increases with manganese intake from food and water.

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Section: Discussioncontrasting

confidence: 76%

Prenatal exposure to manganese in South African coastal communities

Röllin

Kootbodien

Theodorou

et al. 2014

Environ. Sci.: Processes Impacts

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“…While the function of the fifth gene region, LOC284276 , is not currently known, we found that the placental methylation status of cg22284422 within this region was significantly associated with birth weight. The mechanism responsible for the association between methylation of this loci and birth weight is unknown, but it has been suggested that Mn levels in maternal and umbilical cord blood are linked to impaired fetal growth 47–49 . The absence of data characterizing this putative gene limit our ability to understand the nature of this association, but GEO datasets report LOC284276 expression changes to occur in colorectal cancer, prostate cancer, glial brain tumors, and adult acute myeloid leukemia 50 suggesting that it has an important role in growth and development.…”

Section: 1 Discussionmentioning

confidence: 99%

DNA methylation changes in the placenta are associated with fetal manganese exposure

Maccani

Koestler

Houseman

et al. 2015

Reproductive Toxicology

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Adequate micronutrient intake, including manganese (Mn), is important for fetal development. Both Mn deficiencies and excess exposures are associated with later-life disease, and Mn accumulates in the placenta. Placental functional alterations may alter fetal programming and lifelong health, and we hypothesized that prenatal exposures to Mn may alter placental function through epigenetic mechanisms. Using Illumina’s HumanMethylation450 BeadArray, DNA methylation of >485,000 CpG loci genome-wide was interrogated in 61 placental samples and Mn associations assessed genome-wide via omnibus test (p=0.045). 713 loci were associated with Mn exposure (p<0.0001). 5 significantly differentially-methylated (p<1.3×10−7) loci reside in neurodevelopmental, fetal growth and cancer-related genes. cg22284422, within the uncharacterized LOC284276 gene, was associated with birth weight; for every 10% increase in methylation, lower birth weights were observed, with an average decrease of 293.44 grams. Our observations suggests a link between prenatal micronutrient levels, placental epigenetic status and birth weight, although these preliminary results require validation.

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“…In Shanghai study [20], they found that maternal Mn was associated with birth weight (n = 175, mean of maternal whole blood Mn = 6.6 μg/dL, mean of umbilical cord blood Mn = 8.5 μg/dL). In Dalian city study [21], northern China, significant relationship was observed between cord blood Mn and birth weight (n = 125, mean of maternal whole blood Mn = 55.0 μg/L, mean of umbilical cord blood Mn = 78.8 μg/L). The former study found that the birth weight increased Mn levels up to 4.18 μg/dL, the peak point of the latter study was 90.0 μg/L, and then decreased.…”

Section: Discussionmentioning

confidence: 99%

“…The authors examined the relationship between cord serum Mn and birth weight by multiple regression, and did not find a significant association between them, although they found a negative relationship and nonlinear relationship between cord serum Mn and birth length and Ponderal index, respectively [23]. Because blood Mn level in the cord blood is higher than that in maternal blood at the time of delivery [20,21] and this study was conducted with serum, it cannot be directly comparable to our study.…”

Section: Discussionmentioning

confidence: 99%

Maternal blood manganese level and birth weight: a MOCEH birth cohort study

Eum

Cheong

et al. 2014

Environ Health

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BackgroundManganese (Mn) is an essential trace element for humans and animals, but excess intake of Mn can lead to adverse developmental outcome. Few studies have investigated the effects of deficiency or excess of Mn on the human foetus. In this study, we assessed the quantitative relationship between maternal blood Mn and birth weight of a newborn.MethodsWe performed analysis on 331 full-term, live birth singleton mother-infant pairs enrolled from July 2007 to December 2009 in the Mother and Children’s Environmental Health (MOCEH) study in Korea. A questionnaire on general characteristics, a review of medical records, and maternal whole blood Mn analysis were performed at full-term pregnancy. We evaluated the relationship between maternal blood level of Mn and the birth outcome using logistic regression and generalised additive model.ResultsThe mean Mn concentration in whole maternal blood was 22.5 μg/L. We found a curvilinear relationship between maternal blood Mn and birth weight after adjusting for potential confounders. Birth weight peaked at the maternal blood Mn level of 30 and 35 μg/L. An increased probability of birth weight below 3000 g was observed at both below 16.9 μg/L (odds ratio = 2.77, 95% CI: 0.89–8.65) and above 26.9 μg/L of maternal blood Mn level (odds ratio = 2.66, 95% CI: 0.84–8.08).ConclusionsOur study found that both extreme level of maternal Mn level was associated with lower birth weight outcome in a nonlinear fashion.

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Manganese concentrations in maternal and umbilical cord blood: related to birth size and environmental factors

Abstract: Our results suggested that lower or higher Mn level in maternal and umbilical blood may induce adverse effect on birth size in humans. In addition, increased levels of Mn in MWB or UCB may be associated with exposure to some environmental hazard factors.

Cited by 54 publications

References 31 publications

Prenatal exposure to manganese in South African coastal communities

Prenatal exposure to manganese in South African coastal communities

DNA methylation changes in the placenta are associated with fetal manganese exposure

Maternal blood manganese level and birth weight: a MOCEH birth cohort study

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