Manganese Content of Soy or Rice Beverages is High in Comparison to Infant Formulas

Cockell, Kevin A.; Bonacci, Giuseppe; Belonje, B.

doi:10.1080/07315724.2004.10719352

Cited by 32 publications

(28 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This element is readily present in the soil, atmosphere, and plants (Cockell et al 2004). In particular, plants such as soybean and rice are naturally abundant in Mn because they accumulate this ion from the soil.…”

Section: Introductionmentioning

confidence: 98%

Manganese in Children with Attention-Deficit/Hyperactivity Disorder: Relationship with Methylphenidate Exposure

Farias

Cunha

Benko

et al. 2010

Journal of Child and Adolescent Psychopharmacology

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder that affects children worldwide. The etiology of ADHD is complex and not fully understood. Earlier studies associated elevated levels of manganese (Mn) with learning problems, attention deficits, and ADHD. Furthermore, it has also been shown that the dopamine (DA) system, the primary site of action of pharmacological ADHD treatments, is influenced by high levels of Mn. Recent studies have suggested that Mn accumulates in dopaminergic neurons via the presynaptic dopamine transporter (DAT). A role for altered functioning of the dopaminergic system in the etiology of ADHD has been well established through neurochemical, neurophysiological, imaging, and genetics studies. Methylphenidate (MPH) is a psychostimulant commonly used to manage ADHD symptoms. The pharmacotherapeutic effect of MPH occurs primarily through its action of inhibiting DAT, and thus increasing dopamine, as well as other catecholamines, at the synapse. We assessed a group of children with ADHD and matched control children without psychopathology attending public schools in a southern Brazilian city and reported elevated serum concentrations of Mn in treatment-naïve children with ADHD compared to normal controls. Interestingly, children with ADHD receiving concurrent MPH showed no difference in Mn serum levels versus controls. We then prospectively assessed the impact of naturalistic treatment with MPH and determined that Mn concentrations were significantly reduced from baseline values following MPH exposure.

show abstract

Section: Introductionmentioning

confidence: 98%

Manganese in Children with Attention-Deficit/Hyperactivity Disorder: Relationship with Methylphenidate Exposure

Farias

Cunha

Benko

et al. 2010

Journal of Child and Adolescent Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…8 9 also reported Mn levels in milk protein formulas (90 AE 50 mg l À1 ) to be less than in those which are soy based (310 AE 80 mg l À1 ). It has been postulated that the …”

Section: Food Sourcesmentioning

confidence: 87%

“… 81 calculated an upper limit (UL) for infants' intake of Mn, ranging from 50 to 90 mg 100 kcal À1 or 0.35 to 0.6 mg ml À1 . In Japan,Tsutie et al (2010) …”

mentioning

confidence: 99%

Nutritional Requirements for Manganese

Freeland‐Graves¹,

Mousa²,

Sanjeevi³

2014

Manganese in Health and Disease

View full text Add to dashboard Cite

Manganese (Mn) is a ubiquitous trace mineral that is essential for living organisms. This mineral is a cofactor of enzymes such as superoxide dismutase and arginase. It assumes a significant role in the metabolism of carbohydrates, amino acids and cholesterol, the formation of bone, digestion, and development. Food sources include whole grains, cereals, green leafy vegetables, nuts, and tea. Approaches to assess Mn requirements include metabolic balance, blood levels, and response of biomarkers. In the United States, the adequate intake (AI) of Mn is 1.8 and 2.3 mg day−1 for women and men, respectively. Negative balance has been reported in numerous studies, where Mn intake was greater than the AI; thus, the adequacy of current dietary recommendations is unclear. Factors that influence Mn requirements include life stage and gender, bioavailability (fiber, phytates, mineral interactions, polyphenolic compounds), and international considerations. Deficiency of Mn has been associated with adverse health conditions including dermatitis, osteoporosis, dyslipidemia, diabetes, metabolic syndrome, hypertension, epilepsy, cancer, asthma, problems with cognitive function, and poor birth outcomes. Toxicity of Mn may be a potential problem with contaminated drinking water, parenteral nutrition, individuals with hepatic dysfunction, and soy formula-fed infants. An understanding of Mn nutrient requirements is important for achievement of optimal health.

show abstract

“…Elevated levels of Mn have been reported in infants and children 18,19,38,39 and both have been identified as being more sensitive to excess Mn exposure. 16,18,19 Thus, this combination of environmental influences, especially in infants and children which are particularly vulnerable, may result in elevated Mn exposure that could potentially be harmful. Importantly, the 10 mg/kg daily supplemental dose of Mn used in this study did not exceed daily intake amounts previously set by the U.S. National Research Council.…”

Section: Discussionmentioning

confidence: 99%

“…Mn is found in a variety of foods and many geographical regions have higher levels of Mn in the drinking water. 16 High levels of this element have been found in soy baby formulas leading to elevated serum levels; 17–19 thus identifying infants and children as being more sensitive to excess Mn exposure. 16,19 …”

Section: Introductionmentioning

confidence: 99%

Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats

Dearth¹,

Hiney

Srivastava

et al. 2014

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Evidence suggests that environmental substances regulating estrogenic pathways during puberty may be detrimental to the developing mammary gland (MG). Manganese (Mn) is a trace mineral required for normal physiological processes. Prepubertal exposure to Mn induces precocious puberty in rats, an event associated with early elevations in puberty-related hormones, including estradiol (E2). However, until now the effect of Mn-induced precocious MG development has not been determined. Therefore, we assessed the ability of prepubertal Mn exposure to advance normal MG development and alter E2 driven pathways involved in tumorigenesis. Sprague Dawley female rats were gavaged daily with either 10 mg/kg manganese chloride (MnCl2) or saline (control) from postnatal day (PND) 12 through PND 30. Blood and MGs were collected on PNDs 30 and 120. Compared to controls, serum E2 levels on PND 30 were elevated (p<0.05) in the Mn-treated group. Mn exposure significantly increased differentiated MG terminal ductal structures and the percentage of MG epithelial cells that stained positive for the proliferative marker, Ki67, at PND 30 (p<0.001) and PND 120 (p < 0.001). Levels of Mn (ppm) were not elevated in these MGs. Mn-treated animals (40%) exhibited reactive stroma and intra-luminal focal hyperplasia in hemotoxylin and eosin stained MGs at PND 120. Furthermore, Mn exposure resulted in elevated protein expression levels of estrogen receptor α, activator protein 2α, phosphorylated (p)-Akt, and p53 in MGs on PND 120, but not on PND 30. Collectively, these data show that exposure to a supplemental dose of Mn causes accelerated pubertal MG growth which can progress to adult hyperplasia; thus, providing evidence that early life Mn exposure may increase susceptibility to breast cancer.

show abstract

Manganese Content of Soy or Rice Beverages is High in Comparison to Infant Formulas

Abstract: SB/RB should not be fed to infants because they are nutritionally inadequate and contain Mn at levels which may present an increased risk of adverse neurological effects if used as a sole source of nutrition.

Cited by 32 publications

References 21 publications

Manganese in Children with Attention-Deficit/Hyperactivity Disorder: Relationship with Methylphenidate Exposure

Manganese in Children with Attention-Deficit/Hyperactivity Disorder: Relationship with Methylphenidate Exposure

Nutritional Requirements for Manganese

Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats

Contact Info

Product

Resources

About