Manganese dipyridoxyl‐diphosphate (MnDPDP) as a viability marker in patients with myocardial infarction

Skjold, Arne; Amundsen, Brage H.; Wiseth, Rune; Støylen, Asbjørn; Haraldseth, Olav; Larsson, Henrik; Jynge, Per

doi:10.1002/jmri.21065

Cited by 52 publications

(73 citation statements)

References 36 publications

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“…Each rat was infused IV for 30 min with a clinically-relevant dose of Teslascan (10 μmol/kg = 0.01 mmol/kg; n = 4 (continued dark adaptation), n = 5 (subsequent light adaptation) - see table 1 below), saline (volume equivalent sample; n = 5), or a high dose of Teslascan (100 μmol/kg; n = 5). The recommended clinical dose is 5-10 μmol/kg dose [11] [17]. …”

Section: Methodsmentioning

confidence: 99%

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Toward clinical application of manganese-enhanced MRI of retinal function

Tofts¹,

Porchia²,

Jin³

et al. 2010

Brain Research Bulletin

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Purpose-The application of Manganese-Enhanced MRI (MEMRI) to measure retinal function in humans is unclear. To begin to address this gap, we tested the hypothesis that an FDA-approved manganese-based MRI contrast agent, Teslascan, is useful for measuring functional intraretinal ionic regulation.Methods-Anesthetized dark-or light-adapted male healthy Sprague Dawley rats were infused for 30 min with 10 μmol/kg of Teslascan (clinically relevant dose; n=5), 100 μmol/kg Teslascan (n=5), or saline (n=5). Four hours post administration, high resolution MEMRI data were collected. Intraretinal signal intensities and enhancements were measured. Modelling was performed to estimate apparent retinal transfer constant K i and to determine optimal data acquisition parameters.Results-In light-adapted rats, intraretinal enhancements responded in a dose-response manner. In addition, in the outer retina the effect of light-adaptation was to reduce significantly Mn 2+ uptake and K i compared to dark-adaptation. A non-significant change was also observed in the inner retina. Modelling shows Mn 2+ plasma concentration reaching a plateau after about 2 hours. Apparent K i values for the clinically-relevant dose are 3-6 10 -3 min -1 , decreasing to 0.5-0.6 10 -3 min -1 at the higher dose. Intraretinal signal is almost linear with K i . Optimal TR for a spin echo sequence is 0.4-1.4s. Conclusion-Firsttime evidence is presented that a clinically-relevant dose and route of Teslascan can be used to measure intraretinal function. The potential for future clinical application of MEMRI in a broad range of retinopathies is high.

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Section: Methodsmentioning

confidence: 99%

“…In addition, we apply a powerful modelling approach that may help optimize data collection parameters in future human studies, as well as obtaining values of apparent Mn 2+ transfer constant for the retina [13] [14] [15] [16] [17]. …”

Section: Introductionmentioning

confidence: 99%

Toward clinical application of manganese-enhanced MRI of retinal function

Tofts¹,

Porchia²,

Jin³

et al. 2010

Brain Research Bulletin

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“…However, interpretation of the physiological responses of retinal and optic nerves may be confounded by the increased possibility of manganese toxicity from the high initial Mn 2þ concentration. There is some evidence that slower release of Mn 2þ may be useful to prevent this toxicity (75). Another complication of this approach is the penetrating ocular injury caused by injection of the manganese, which can have, for example, an associated reactive inflammatory response.…”

Section: Ionic Regulationmentioning

confidence: 99%

Prognostic MRI biomarkers of treatment efficacy for retinopathy

Berkowitz

Roberts

2008

NMR in Biomedicine

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There is a pressing need for retina-specific imaging biomarkers that robustly measure early (subclinical) changes in physiology, are linked to the histopathology responsible for vision loss, and, importantly, predict treatment efficacy. This review focuses on the following four MRI markers that we have developed and applied in preclinical and clinical settings: preretinal vitreous oxygen level (a steady-state biomarker of inner retinal oxygen tension); leakage of contrast agent into the vitreous (a steady-state biomarker of blood-retinal barrier permeability surface area product); change in preretinal vitreous oxygen tension during a hyperoxic provocation (a functional biomarker of vascular autoregulation); and retinal uptake of systemically administered manganese during a visual task (a functional biomarker of intraretinal ion regulation). We conclude that functional biomarkers are most promising for prognostic evaluation of treatment efficacy earlier in the course of retinopathy than is currently possible.

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“…diethylene triamine pentaacetic acid (DTPA) and dipyridoxal diphosphate (DPDP). Two Mn(II)-based agents, the liver-specific Mn-DPDP (Teslascan™) 26 and an oral contrast containing Mn(II) chloride (LumenHance™), 27 are available clinically for human use. A recent study in rats indicated that the optimal MnCl 2 dose for manganese enhanced MRI of the rat would be 150–300 nmol.…”

Section: Introductionmentioning

confidence: 99%

Manganese-based MRI contrast agents: past, present, and future

Pan¹,

Schmieder²,

Wickline³

et al. 2011

Tetrahedron

356

288

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Paramagnetic and superparamagnetic metals are used as contrast materials for magnetic resonance (MR) based techniques. Lanthanide metal gadolinium (Gd) has been the most widely explored, predominant paramagnetic contrast agent until the discovery and association of the metal with nephrogenic systemic fibrosis (NSF), a rare but serious side effects in patients with renal or kidney problems. Manganese was one of the earliest reported examples of paramagnetic contrast material for MRI because of its efficient positive contrast enhancement. In this review, manganese based contrast agent approaches are discussed with a particular emphasis on their synthetic approaches. Both small molecules based typical blood pool contrast agents and more recently developed novel nanometer sized materials are reviewed focusing on a number of successful molecular imaging examples.

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Manganese dipyridoxyl‐diphosphate (MnDPDP) as a viability marker in patients with myocardial infarction

Abstract: Remote regions showed larger increases in R(1) than infarcted regions. This is most likely due to selective and slow Mn accumulation in viable myocytes.

Cited by 52 publications

References 36 publications

Toward clinical application of manganese-enhanced MRI of retinal function

Toward clinical application of manganese-enhanced MRI of retinal function

Prognostic MRI biomarkers of treatment efficacy for retinopathy

Manganese-based MRI contrast agents: past, present, and future

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