Manganese encephalopathy: utility of early magnetic resonance imaging.

Nelson, Kevin L.; Golnick, Jan; Korn, Thomas; Angle, Carol R.

doi:10.1136/oem.50.6.510

Cited by 122 publications

(128 citation statements)

References 10 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…Manganese toxicity had previously been reported in miners after a prolonged exposure to manganese dust, resulting in extrapyramidal symptoms resembling Parkinson's disease. 27 In cirrhotic patients, a high incidence of extrapyramidal symptoms, in particular rigidity, similar to that observed in Parkinson's disease, is observed when a detailed and careful neurological evaluation is performed. 5 and 25 However, recent reports evaluating the relationship between blood manganese, pallidal hyperintensity, and neurological symptoms have yielded conflicting results.…”

Section: Discussionmentioning

confidence: 94%

Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction

et al. 1999

View full text Add to dashboard Cite

Background & Aims: Manganese (Mn) deposition could be responsible for the T1-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional specificity of the Mn increases as well as their relationship to portal-systemic shunting or hepatobiliary dysfunction. Methods: Mn concentrations were measured in (1) brain samples from basal ganglia structures (pallidum, putamen, caudate nucleus) and cerebral cortical structures (frontal, occipital cortex) obtained at autopsy from 12 cirrhotic patients who died in hepatic coma and from 12 matched controls; and from (2) brain samples (caudate/putamen, globus pallidus, frontal cortex) from groups (n = 8) of rats either with end-to-side portacaval anastomosis, with biliary cirrhosis, or with fulminant hepatic failure as well as from sham-operated and normal rats. Results: Mn content was significantly increased in frontal cortex (by 38%), occipital cortex (by 55%), pallidum (by 186%), putamen (by 66%), and caudate (by 54%) of cirrhotic patients compared with controls. Brain Mn content did not correlate with patient age, etiology of cirrhosis, or history of chronic hepatic encephalopathy. In cirrhotic and portacaval-shunted rats, Mn content was increased in pallidum (by 27% and 57%, respectively) and in caudate/putamen (by 57% and 67%, respectively) compared with control groups. Mn concentration in pallidum was significantly higher in portacaval-shunted rats than in cirrhotic rats. No significant changes in brain Mn concentrations were observed in rats with acute liver failure. Conclusions: These findings suggest that brain Mn deposition results both from portal-systemic shunting and from liver dysfunction.

show abstract

Section: Discussionmentioning

confidence: 94%

Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction

et al. 1999

View full text Add to dashboard Cite

show abstract

“…Regardless of the administration route of MnCl 2 , an increasing signal intensity on MRI is observed in the caudate nucleus, globus pallidus, substantia nigra, ventromedial hypothalamus, and pituitary gland [23]. Even in man, a hyperintense globus pallidus was found in patients receiving long-term total parenteral nutrition therapy that included manganese [24] and in workers exposed to manganese [25][26][27], with these hyperintensities diminishing after cessation of the manganese exposure [25,28,29]. Intravenous administration or inhalation of manganese causes manganese deposition in the brain, but the oral intake of manganese rarely results in manganese deposition.…”

Section: Manganesementioning

confidence: 98%

Contribution of metals to brain MR signal intensity: review articles

et al. 2016

View full text Add to dashboard Cite

“…The characteristic high signal intensities mainly confined to the GP have been observed in T1-weighted MRI in experimental Mn poisoning of nonhuman primates 1) and also in a patient with Mn neurointoxication 2) . Furthermore, the characteristic high signals are also frequently observed in asymptomatic workers exposed to Mn 3) .…”

mentioning

confidence: 95%

Whole Blood and Red Blood Cell Manganese Reflected Signal Intensities of T1‐Weighted Magnetic Resonance Images better than Plasma Manganese in Liver Cirrhotics

Choi¹,

Park²,

Park³

et al. 2005

Journal of Occupational Health

View full text Add to dashboard Cite

Whole Blood and Red Blood Cell Manganese Reflected Signal Intensities of T1-Weighted Magnetic Resonance Images better thanPlasma Manganese in Liver Cirrhotics: Younghee CHOI, et al. Department of Occupational and Environmental Medicine, Ulsan University Hospital, South Korea-We examined whole blood (MnB), red blood cell (MnRBC), plasma (MnP) and urinary Mn (MnU) concentrations in 22 liver cirrhotics and 10 healthy controls to evaluate Mn concentration in which a fraction of biological samples best reflects pallidal signal intensities (pallidal index; PI) on T1-weighted magnetic resonance images (MRI) in liver cirrhotics. Increased signal intensity in the globus pallidus was observed in 18 (81.8%) of the 22 patients with liver cirrhosis. In a transplanted patient, increased pallidal signals also resolved as his liver function tests normalized after liver transplantation. There were significant correlations between MnB/MnRBC and PI (ρ=0.529, ρ=0.573, respectively) in liver cirrhotics, although no significant correlation was observed between MnP/MnU and PI. According to a multiple linear regression, MnB and MnRBC reflected the signal intensities of T1-weighted MRI better than MnP or MnU. (J Occup Health 2005; 47: 68-73)

show abstract

Manganese encephalopathy: utility of early magnetic resonance imaging.

Cited by 122 publications

References 10 publications

Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction

Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction

Contribution of metals to brain MR signal intensity: review articles

Whole Blood and Red Blood Cell Manganese Reflected Signal Intensities of T1‐Weighted Magnetic Resonance Images better than Plasma Manganese in Liver Cirrhotics

Contact Info

Product

Resources

About