Manganese-enhanced MR imaging of brain activation evoked by noxious peripheral electrical stimulation

Cha, Min‐Ji; Lee, Kyuhong; Lee, Chulhyun; Cho, Jee-Hyun; Cheong, Chaejoon; Sohn, Jong Hee; Lee, Bae Hwan

doi:10.1016/j.neulet.2015.11.027

Cited by 8 publications

(17 citation statements)

References 27 publications

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“…Manganese‐enhanced MRI (MEMRI) has been used to assess various conditions associated with Ca 2+ ions, such as brain activity (Cha et al . ; Schroeder et al . ), neuronal tract tracing and axonal transport (Inoue et al .…”

Section: Introductionmentioning

confidence: 99%

“…Mn 2+ is a divalent cation similar in ionic radius and chemical properties to Ca 2+ that can pass through various Ca 2+ channels, and its paramagnetic properties make it a potent MRI spin lattice relaxation time constant (T1) contrast agent (Naruse & Sokabe, 1993;Dryselius et al 1999;Takeda, 2003;Waghorn et al 2009). Manganese-enhanced MRI (MEMRI) has been used to assess various conditions associated with Ca 2+ ions, such as brain activity (Cha et al 2016;Schroeder et al 2016), neuronal tract tracing and axonal transport (Inoue et al 2011;Majid et al 2014), injury (Rodriguez et al 2016;Yang et al 2016), ischaemia-reperfusion (Zhao et al 2015) and cardiac function (Chen et al 2012;Andrews et al 2015). However, it has never been used to assess aberrant Ca 2+ handling in dystrophic skeletal muscle.…”

Section: Introductionmentioning

confidence: 99%

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Eliminating Nox2 reactive oxygen species production protects dystrophic skeletal muscle from pathological calcium influx assessed in vivo by manganese‐enhanced magnetic resonance imaging

Loehr

Stinnett

Hernández‐Rivera

et al. 2016

The Journal of Physiology

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Duchenne muscular dystrophy (DMD) is an X-linked progressive degenerative disease resulting from a mutation in the gene that encodes dystrophin, leading to decreased muscle mechanical stability and force production. Increased Nox2 reactive oxygen species (ROS) production and sarcolemmal Ca influx are early indicators of disease pathology, and eliminating Nox2 ROS production reduces aberrant Ca influx in young mdx mice, a model of DMD. Various imaging modalities have been used to study dystrophic muscle in vivo; however, they are based upon alterations in muscle morphology or inflammation. Manganese has been used for indirect monitoring of calcium influx across the sarcolemma and may allow detection of molecular alterations in disease progression in vivo using manganese-enhanced magnetic resonance imaging (MEMRI). Therefore, we hypothesized that eliminating Nox2 ROS production would decrease calcium influx in adult mdx mice and that MEMRI would be able to monitor and differentiate disease status in dystrophic muscle. Both in vitro and in vivo data demonstrate that eliminating Nox2 ROS protected against aberrant Ca influx and improved muscle function in dystrophic muscle. MEMRI was able to differentiate between different pathological states in vivo, with no long-term effects on animal health or muscle function. We conclude that MEMRI is a viable, non-invasive technique to differentiate disease status and might provide a means to monitor and evaluate the effectiveness of potential therapies in dystrophic muscle.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eliminating Nox2 reactive oxygen species production protects dystrophic skeletal muscle from pathological calcium influx assessed in vivo by manganese‐enhanced magnetic resonance imaging

Loehr

Stinnett

Hernández‐Rivera

et al. 2016

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…[24] In addition, the cumulative Mn 2+ pattern is retained for several days, and it also provides a good opportunity to observe activated brain changes by stimulation when viewed through T1-weighted MRI [6]. Quantitative evaluation of contrast enhancement showed that MnCl 2 injection via ECA may be the best way to show hind paw stimulation-induced pain in rats, with the best signal-to-noise ratio [3].…”

Section: The Meaning Of Mn 2+ Enhancement In Roismentioning

confidence: 99%

“…Magnetic resonance imaging (MRI) techniques are essential tools for the study of cerebral activities. Current manganese-enhanced MRI (MEMRI) tools have provided a visible method for demonstrating the cortical response after evoked and/or spontaneous pain [3,4]. The chemical properties of Mn 2+ resemble those of Ca 2+ , and Mn 2+ acts as a paramagnetic neuronal tract tracer as its transport uses voltage-gated Ca 2+ channels throughout the nervous system [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Manganese-enhanced MRI depicts a reduction in brain response to nociception by mTOR inhibition in chronic pain rats

Cha

Choi

Kim

et al. 2020

Preprint

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Neuropathic pain induced by a nerve injury could lead to chronic pain. Recent studies have reported hyperactive neural activities in the nociceptive-related area of the brain as a result of chronic pain. Although cerebral activities associated with hyperalgesia and allodynia in the chronic pain model were difficult to represent with functional imaging techniques, advances in manganese (Mn)-enhanced magnetic resonance imaging (MEMRI) could facilitate the visualization of the activation of pain-specific neural responses in the cerebral cortex. In order to investigate the alleviation of pain nociception by mammalian target of rapamycin (mTOR) modulation, we observed the cerebrocortical excitability changes and compared the regional Mn 2+ enhancement after mTOR inhibitions. At day 7 after nerve injury, drugs were applied into the intracortical area, and drug (Vehicle, Torin1 and XL388) effects were compared within groups using MEMRI. In the results, signal intensities of the insular cortex (IC), primary somatosensory cortex of the hind limb region (S1HL), motor cortex 1/2 (M1/2), and anterior cingulate cortex (ACC) regions were significantly reduced after application of mTOR inhibitors (Torin1 and XL388). Furthermore, the rostral-caudal analysis of the IC indicated that the rostral region of the IC was more associated with pain perception than caudal region. Our data suggest that MEMRI could present the pain-related signal changes in the brain, and mTOR inhibition is closely correlated with pain modulation in chronic pain rats.

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“…While identifying brain abnormalities underlying chronic pain sensation could be a rst step in clinical treatment, investigation of changes in cerebral neuronal activity is a challenge for functional imaging. Nevertheless, current manganeseenhanced magnetic resonance imaging (MEMRI) tools have provided a viable method for visualizing cortical responses after evoked and/or spontaneous pain [2,3]. The chemical properties of Mn 2+ resemble those of Ca 2+ , and Mn 2+ acts as a paramagnetic neuronal tract tracer, as its transport uses voltage-gated Ca 2+ channels throughout the nervous system [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Manganese-enhanced MRI depicts a reduction in brain response to nociception upon mTOR inhibition in chronic pain rats

Cha

Choi

Kim

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Neuropathic pain induced by a nerve injury can lead to chronic pain. Recent studies have reported hyperactive neural activities in the nociceptive-related area of the brain as a result of chronic pain. Although cerebral activities associated with hyperalgesia and allodynia in chronic pain models are difficult to represent with functional imaging techniques, advances in manganese (Mn)-enhanced magnetic resonance imaging (MEMRI) could facilitate the visualization of the activation of pain-specific neural responses in the cerebral cortex. In order to investigate the alleviation of pain nociception by mammalian target of rapamycin (mTOR) modulation, we observed cerebrocortical excitability changes and compared regional Mn 2+ enhancement after mTOR inhibition. At day 7 after nerve injury, drugs were applied into the intracortical area, and drug (Vehicle, Torin1, and XL388) effects were compared within groups using MEMRI. Therein, signal intensities of the insular cortex (IC), primary somatosensory cortex of the hind limb region, motor cortex 1/2, and anterior cingulate cortex regions were significantly reduced after application of mTOR inhibitors (Torin1 and XL388). Furthermore, rostral-caudal analysis of the IC indicated that the rostral region of the IC was more strongly associated with pain perception than the caudal region. Our data suggest that MEMRI can depict pain-related signal changes in the brain and that mTOR inhibition is closely correlated with pain modulation in chronic pain rats.

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Manganese-enhanced MR imaging of brain activation evoked by noxious peripheral electrical stimulation

Cited by 8 publications

References 27 publications

Eliminating Nox2 reactive oxygen species production protects dystrophic skeletal muscle from pathological calcium influx assessed in vivo by manganese‐enhanced magnetic resonance imaging

Eliminating Nox2 reactive oxygen species production protects dystrophic skeletal muscle from pathological calcium influx assessed in vivo by manganese‐enhanced magnetic resonance imaging

Manganese-enhanced MRI depicts a reduction in brain response to nociception by mTOR inhibition in chronic pain rats

Manganese-enhanced MRI depicts a reduction in brain response to nociception upon mTOR inhibition in chronic pain rats

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