Manganese ferrite nanocubes as an MRI contrast agent

Ravichandran, M.; Velumani, S.

doi:10.1088/2053-1591/ab66a4

Cited by 26 publications

(5 citation statements)

References 38 publications

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“…The crystallite sizes estimated using the Debye–Scherrer equation based on the strongest (311) peaks were 2.76, 9.89, and 17.58 nm, which are well-consistent with the observation under TEM imaging. These characterization results illustrate that MFNPs with ultrasmall (3 nm), − , medium (10 nm), , and large (18 nm) ,− sizes were well-prepared. The obtained MFNPs were dispersed in aqueous solution by DHCA modification.…”

Section: Resultsmentioning

confidence: 59%

“…Manganese ferrite nanoparticles (MFNPs) have been proven to be a promising alternative to magnetic resonance imaging (MRI) contrast agents due to their tunable magnetic properties. − The longitudinal and transverse relaxivities of MFNPs in MRI are highly size- and component-dependent. ,− Large MFNPs, accelerating transverse relaxation of water protons, are excellent T 2 contrast agents, ,,,− while ultrasmall MFNPs (<5 nm) show a remarkable longitudinal relaxivity ( r 1 ), making them the best candidate for nongadolinium T 1 contrast agents for MRI. ,, The medium-sized MFNPs between large and ultrasmall exhibit both T 1 and T 2 contrast enhancement effects. , Recently, MFNPs were designed to respond to a hypoxic tumor microenvironment (TME), catalyzing the decomposition of H 2 O 2 in cancer cells and then enhancing the therapeutic efficiency of photodynamic therapy, chemoimmunotherapy, photothermal therapy, and radiotherapy under MRI modes to achieve precise and effective image-guided tumor therapy.…”

Section: Introductionmentioning

confidence: 99%

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The Metal Ion Release of Manganese Ferrite Nanoparticles: Kinetics, Effects on Magnetic Resonance Relaxivities, and Toxicity

Zhang

Wang

et al. 2022

ACS Appl. Bio Mater.

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Mn2+ release is particularly important for biological application of manganese-based nanomaterials. However, the Mn2+ release profiles of the manganese ferrite nanoparticles are under clarification. Here, we synthesized 3, 10, and 18 nm manganese ferrite nanoparticles (MFNPs) as model systems to study the Mn2+ release behavior, size, and pH-dependent kinetics. The Mn2+ release kinetic study showed that the first-order kinetic model was suitable for 3 and 10 nm MFNPs, while the Higuchi model was suitable for 18 nm MFNPs in a neutral PBS buffer (pH 7.4). In an acidic PBS buffer (pH 4.8), the Mn2+ release from all sizes of MFNPs follows first-order kinetics, which is possible due to the reaction between MFNPs and H+. The influence of Mn2+ release was evaluated by comparing the variations of magnetic resonance (MR) relaxation and magnetic properties before and after Mn2+ release of MFNPs. The results showed that the saturation magnetization (M s), longitudinal relaxivity (r 1), and transverse relaxivity (r 2) values declined due to Mn2+ release, while the ratio of r 2/r 1 increased slightly, showing that all sizes of MFNPs exhibited the same MR mode as the synthesized MFNPs. More importantly, the release kinetics were employed to estimate the toxicity of the released Mn2+ in vivo. The potential toxicity is acceptable for MFNP administration since the calculated amount of Mn2+ is in the range of safe doses.

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Section: Resultsmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

The Metal Ion Release of Manganese Ferrite Nanoparticles: Kinetics, Effects on Magnetic Resonance Relaxivities, and Toxicity

Zhang

Wang

et al. 2022

ACS Appl. Bio Mater.

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“…Intravenous inoculation of ferrite nanosized particles can be useful as contrast agents for magnetic resonance imaging (MRI) [ 44 ]. Mn ferrite was found as a very effective MRI contrast agent in comparison with magnetite since it has large M S and high crystalline anisotropy resulting in a slower magnetic moment of relaxation [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Dependence of Structural, Morphological and Magnetic Properties of Manganese Ferrite on Ni-Mn Substitution

Dippong

Levei

Deac

et al. 2022

IJMS

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This paper presents the influence of Mn2+ substitution by Ni2+ on the structural, morphological and magnetic properties of Mn1−xNixFe2O4@SiO2 (x = 0, 0.25, 0.50, 0.75, 1.00) nanocomposites (NCs) obtained by a modified sol-gel method. The Fourier transform infrared spectra confirm the formation of a SiO2 matrix and ferrite, while the X-ray diffraction patterns show the presence of poorly crystalline ferrite at low annealing temperatures and highly crystalline mixed cubic spinel ferrite accompanied by secondary phases at high annealing temperatures. The lattice parameters gradually decrease, while the crystallite size, volume, and X-ray density of Mn1−xNixFe2O4@SiO2 NCs increase with increasing Ni content and follow Vegard’s law. The saturation magnetization, remanent magnetization, squareness, magnetic moment per formula unit, and anisotropy constant increase, while the coercivity decreases with increasing Ni content. These parameters are larger for the samples with the same chemical formula, annealed at higher temperatures. The NCs with high Ni content show superparamagnetic-like behavior, while the NCs with high Mn content display paramagnetic behavior.

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“…The relaxivity is directly related to the particle size and magnetic moment of nanoparticles. In MnFe 2 O 4, the transverse relaxivity increases with particle size [27][28][29]. TheT 1 and T 2 relaxivities of silicacoated manganese ferrite nanoparticles in water were 1.42 and 60.65 s −1 mM −1 respectively and r 2 /r 1 was 48.91, which confirm that these nanoparticles have potential as highly efficient T 2 contrast agents [30].…”

Section: Mri (Magnetic Resonance Imaging)mentioning

confidence: 93%

The Role of Nanoferrites in Bio-medical Applications

Sarveena

2021

Engineering Materials

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Magnetic nanoferrites have shown immense potential in the biomedical applications due to its ability to precisely control the behavior by application of external magnetic field. Superior magnetic properties of ferrites make them promising nanoagents in various applications like targeted drug delivery, magnetic separation, biosensors, MRI, antimicrobial agents and magnetic hyperthermia (MHT). The challenge is to maintain the high magnetization which decreases when size is reduced to nanoscale, hence the engineering of these nanoferrites is of prime importance, where selection of appropriate synthesis method plays very important role. Hence the parameters like morphology, biocompatibility, chemical and physical properties affect the efficiency of nanoferrites in biomedical applications. IntroductionNanoferrites have numerous biomedical applications due to their size comparable to biological molecules and excellent magnetic properties, which are prerequisites for all biomedical applications. Due to the transparency of biological tissues to magnetic field, various properties can be tuned when nanoferrites interacts with magnetic field. These unique properties of magnetic nanoferrites along with the stability, sensitivity and easy functionalization makes them the future biomedical materials in numerous applications like targeted biosensors, drug delivery, MRI imaging, magnetic separation, antimicrobial agents, magnetic hyperthermia, detoxification, photoablation therapy [1,2]. The magnetic characteristics of ferrite nanoparticles strongly affect its performance in biomedical applications. For example, saturation magnetization is Sarveena (B)

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Manganese ferrite nanocubes as an MRI contrast agent

Cited by 26 publications

References 38 publications

The Metal Ion Release of Manganese Ferrite Nanoparticles: Kinetics, Effects on Magnetic Resonance Relaxivities, and Toxicity

The Metal Ion Release of Manganese Ferrite Nanoparticles: Kinetics, Effects on Magnetic Resonance Relaxivities, and Toxicity

Dependence of Structural, Morphological and Magnetic Properties of Manganese Ferrite on Ni-Mn Substitution

The Role of Nanoferrites in Bio-medical Applications

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