Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging

Lü, Jian; Ma, Shuli; Sun, Jiayu; Xia, Chunchao; Liu, Chen; Zhi-yong, Wang; Zhao, Xüna; Gao, Fabao; Gong, Qiyong; Song, Bin; Shuai, Xintao; Ai, Hua; Gu, Zhongwei

doi:10.1016/j.biomaterials.2009.02.001

Cited by 331 publications

(220 citation statements)

References 50 publications

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“…The presence of FAPLCS/SPIONs ( Figure 6A) and PLCS/SPIONs in water induced signal losses in T 2 -weighted MRI images similar to that observed with increased iron concentration. 32 The shortened T 2 relaxation times of both FAPLCS/SPION micelles ( Figure 6B) and PLCS/SPION micelles were well correlated by linear regression analysis within the range of iron concentrations studied (0.015-0.24 mM) and displayed the characteristic SPION property of shortened T 2 relaxation times. 32 …”

Section: T 2 Relaxivitymentioning

confidence: 65%

“…The magnetization curves of micelles indicated that they are superparamagnetic in 1:300 K because the net magnetization returned to 0 without an external field. 32 Owing to the decrease in their SPION content, the Ms of SPIONs was markedly reduced after encapsulation by polymeric micelles, although FAPLCS/SPIONs still exhibited promising superparamagnetic behavior. Similar Ms changes were observed in previous studies using SPIONs encapsulated in chitosan derivatives that stably retained the magnetic properties of SPIONs.…”

Section: Magnetic Properties Of Polymeric Micellesmentioning

confidence: 99%

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High molecular weight chitosan derivative polymeric micelles encapsulating superparamagnetic iron oxide for tumor-targeted magnetic resonance imaging

Xiao

Lin

Chen

et al. 2015

IJN

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Magnetic resonance imaging (MRI) contrast agents based on chitosan derivatives have great potential for diagnosing diseases. However, stable tumor-targeted MRI contrast agents using micelles prepared from high molecular weight chitosan derivatives are seldom reported. In this study, we developed a novel tumor-targeted MRI vehicle via superparamagnetic iron oxide nanoparticles (SPIONs) encapsulated in self-aggregating polymeric folate-conjugated N-palmitoyl chitosan (FAPLCS) micelles. The tumor-targeting ability of FAPLCS/SPIONs was demonstrated in vitro and in vivo. The results of dynamic light scattering experiments showed that the micelles had a relatively narrow size distribution (136.60±3.90 nm) and excellent stability. FAPLCS/SPIONs showed low cytotoxicity and excellent biocompatibility in cellular toxicity tests. Both in vitro and in vivo studies demonstrated that FAPLCS/SPIONs bound specifically to folate receptor-positive HeLa cells, and that FAPLCS/SPIONs accumulated predominantly in established HeLa-derived tumors in mice. The signal intensities of T 2 -weighted images in established HeLa-derived tumors were reduced dramatically after intravenous micelle administration. Our study indicates that FAPLCS/SPION micelles can potentially serve as safe and effective MRI contrast agents for detecting tumors that overexpress folate receptors.

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Section: T 2 Relaxivitymentioning

confidence: 65%

Section: Magnetic Properties Of Polymeric Micellesmentioning

confidence: 99%

High molecular weight chitosan derivative polymeric micelles encapsulating superparamagnetic iron oxide for tumor-targeted magnetic resonance imaging

Xiao

Lin

Chen

et al. 2015

IJN

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“…An alternative route is to embed multiple magnetic NPs into a single multicore micelle. 27,[62][63][64] When the NPs aggregate, the size of the single multicore micelle will be increased into static dephasing regime and their r 2 value will be further increased through the static dephasing relaxation mechanism. In this work, we first synthesized the hydrophobic MnFe 2 O 4 NPs with a size of ~7.5 nm, which was in the regime of motional averaging.…”

Section: Figurementioning

confidence: 99%

Targeting T<sub>1</sub> and T<sub>2</sub> dual modality enhanced magnetic resonance imaging of tumor vascular endothelial cells based on peptides-conjugated manganese ferrite nanomicelles

Gong

Yang

Zhang

et al. 2016

IJN

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Tumor angiogenesis plays very important roles for tumorigenesis, tumor development, metastasis, and prognosis. Targeting T 1 /T 2 dual modality magnetic resonance (MR) imaging of the tumor vascular endothelial cells (TVECs) with MR molecular probes can greatly improve diagnostic sensitivity and specificity, as well as helping to make an early diagnosis of tumor at the preclinical stage. In this study, a new T 1 and T 2 dual modality nanoprobe was successfully fabricated. The prepared nanoprobe comprise peptides CL 1555, poly(ε-caprolactone)-block-poly(ethylene glycol) amphiphilic copolymer shell, and dozens of manganese ferrite (MnFe 2 O 4 ) nanoparticle core. The results showed that the hydrophobic MnFe 2 O 4 nanoparticles were of uniform spheroidal appearance and narrow size distribution. Due to the self-assembled nanomicelles structure, the prepared probes were of high relaxivity of 281.7 mM −1 s −1 , which was much higher than that of MnFe 2 O 4 nanoparticles (67.5 mM 1 s −1 ). After being grafted with the targeted CD105 peptide CL 1555, the nanomicelles can combine TVECs specifically and make the labeled TVECs dark in T 2 -weighted MR imaging. With the passage on, the Mn 2+ ions were released from MnFe 2 O 4 and the size decreased gradually, making the signal intensity of the second and third passage of labeled TVECs increased in T 1 -weighted MR imaging. Our results demonstrate that CL-poly(ethylene glycol)-MnFe 2 O 4 can conjugate TVECs and induce dark and bright contrast in MR imaging, and act as a novel molecular probe for T 1 - and T 2 -enhanced MR imaging of tumor angiogenesis.

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“…[1][2][3][4][5][6] Recently, magnetic nanoparticles have been synthesized using various well defined approaches, such as thermal decomposition and coprecipitation processes. Magnetic nanoparticles synthesized by thermal decomposition have well defined crystallinity and magnetic sensitivity.…”

Section: Introductionmentioning

confidence: 99%

One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging

Kukreja

Lim²,

Kang

et al. 2014

IJN

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In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.

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Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging

Cited by 331 publications

References 50 publications

High molecular weight chitosan derivative polymeric micelles encapsulating superparamagnetic iron oxide for tumor-targeted magnetic resonance imaging

High molecular weight chitosan derivative polymeric micelles encapsulating superparamagnetic iron oxide for tumor-targeted magnetic resonance imaging

Targeting T<sub>1</sub> and T<sub>2</sub> dual modality enhanced magnetic resonance imaging of tumor vascular endothelial cells based on peptides-conjugated manganese ferrite nanomicelles

One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging

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