The discharge of synthetic dyes imparting serious consequences on life. Therefore, an environment-friendly co-precipitation method was utilized to prepare the nanocomposites of doped Nickel ferrite as novel adsorbents for eradication of DB-199 dye. The maximum pH for synthesized ZnxNi1-xFe2O4, MnxNi1-xFe2O4, MgxNi1-xFe2O4, CuxNi1-xFe2O4 and CaxNi1-xFe2O4 were reported to be 2 and 3 with 0.05 g/50 mL maximum adsorbent dosage of synthesized doped Nickel ferrite respectively. The optimum contact time was found at 60 min and 45 min. The maximum initial concentration of DB-199 Dye and the respective adsorption capacity for ZnxNi1-xFe2O4, MnxNi1-xFe2O4, MgxNi1-xFe2O4, CuxNi1-xFe2O4, and CaxNi1-xFe2O4 was found 50 mg L1- (33.169 mg g1-), 75 mg L1- (48.610 mg g1-), 75 mg L1- (46.657 mg g1-), 50 mg L1- (31.150 mg g1-) and 75 mg L1- (44.840 mg g1-) were acquired. All the adsorbents ZnxNi1-xFe2O4, MnxNi1-xFe2O4, MgxNi1-xFe2O4, CuxNi1-xFe2O4, and CaxNi1-xFe2O4 showed their optimum absorption 32.833 mg g1-, 38.892 mg g1-, 36.939 mg g1-, 30.880 mg g1- and 34.852 mg g1- respectively at 30 ºC. Among the applied Kinetics models, pseudo-first-order and pseudo-second-order while isotherm models, Langmuir and D-R models showed satisfactory fitness. The adsorption process for doped nickel ferrite nanoparticles was found to be exothermic in nature.