Manganese(II) complexes of tolfenamic acid or naproxen in polymeric structures or encapsulated in [15-MC-5] manganese(III) metallacrowns: Structure and biological activity

pH-Sensitive Gold Nanorods for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Delivery and DNA-Binding Studies

“…More specifically, in the UVvis spectrum of AuNRs@PEG, the band observed at 525 nm (Figure 4A) exhibited in the presence of CT a slight hypochromism accompanied by a slight red shift (Table 1). In the UV-vis spectrum of AuNRs@PEG@NAP, two basic bands were observed (Figure 4B); band I at 530 nm which may be attributed to the presence of a Au-nanorod since it was also found for AuNRs@PEG and band II at 319 nm which may be assigned to the presence of naproxen, as also found in reported naproxen complexes [35][36][37][38][39]. In the presence of CT DNA, these two bands showed a slight hypochromism up to 10% followed by a slight bathochromism (Table 1).…”

“…This may suggest that the incorporation of naproxen in the AuNRs@PEG may lead to a tighter interaction with CT DNA than the free NAP. A comparison of the DNA-binding constant of AuNRs@PEG@NAP with the reported metal-naproxen complexes may reveal that AuNRs@PEG@NAP is a slightly tighter DNA-binder than the Co(II) [37], Cu(II) [38], and most Mn(II) [35,36] complexes of naproxen, and similar to Sn(IV) [41] and Ag(I) [42] complexes, while the polyethyleneimine-functionalized carbon nanotube hosting naproxen [43], the water-soluble silica hybrid spin-crossover nanoparticle loaded with naproxen [44], and the reported Ni(II)-naproxen complexes present higher K b values [39] than AuNRs@PEG@NAP.…”

Metal Complexes with Naphthalene-Based Acetic Acids as Ligands: Structure and Biological Activity

“…where it also exists in the µ 2 -O mode [89], (ii) aqua ligands bridging two Cd(II [84], (iii) µ 3 -phenyl-phosphonato and (iv) µ 2 -isopropoxo ligands in the hexanuclear complex EHOGOZ [89], and (v) (µ 2 -Hsal-O,O ) and (vi) (µ 2 -shi-N,O) ligands in the complex NI-HVEI [90] (Figure 21).…”

“…The hexanuclear complex [Mn 6 (µ 3 -NAP-O,O,O )(µ 2 -Hsal-O,O )(µ 2shi-N,O) 5 (py) 6 ] is better described as a metallacrown (MC) complex Mn(II)(µ 3 -NAP-O,O,O )(µ 2 -Hsal-O,O )[15-MC Mn(III)N(shi) -5](py) 6 . In this complex, five Mn(III) and five triply deprotonated shi 3bridging ligands are located in a close circular arrangement with five [Mn-N-O] repeating units forming a 15-membered MC ring of the type [15-MC-5] that can encapsulate the sixth Mn(II) ion which is further stabilized by the µ 3 -naproxen-O,O,O and µ 2 -salicylato-O,O bridges with the MC Mn(III) ions [90].…”

“…The polymeric complexes containing 1-naphthylacetato and naproxen ligands are summarized in Table 4 and may be categorized in two groups: (I) the polymeric complexes that are polymerized via the 1-naphthylacetato and naproxen ligands [41,46,59,88,[90][91][92][93] (Table 4, part I), Figure 22) and (II) the polymeric complexes that are polymerized via other co-ligands, and the 1-naphthylacetato and naproxen ligands are just found in the coordination sphere [84,94,95] (Table 4, part II). Most of the reported polymeric complexes bear a monomeric complex as the basis of the polymer with the exception of complexes FUVZIH and CAVHOA which have a trinuclear Cd(II) and a tetranuclear Ag(I) complex, respectively, as the repeating unit of the polymeric structure.…”