Manganese(III) complexes with tetradentate salicylaldimine Schiff bases: Synthesis, structure, self assembly and catalase activity

Sarkar, Nandita; Bhaumik, Prasanta Kumar; Chattopadhyay, Shouvik

doi:10.1016/j.poly.2016.04.013

Cited by 32 publications

(9 citation statements)

References 40 publications

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“…Considering the magnitude of ever-growing antibacterial resistance, it is necessary to discover novel Schiff bases with resistance improved pharmacological profile. We chose to synthesize a library of Schiff bases from 1-hydroxy-2-acetonapthanone and diamines having 3-carbon spacer since it offers tetradentate and flexible nature to the new Schiff bases [56, 57, 58, 59, 60].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, spectroscopic studies and biological evaluation of Schiff bases derived from 1–hydroxy-2-acetonapthanone

Vhanale

Deshmukh

Shinde

2019

Heliyon

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The four Schiff bases (I - IV) were synthesized by the condensation reaction of 1(1-hydroxynaphthalen-2-yl)ethanone, 1-(4-chloro-1hydroxynaphthalen-2-yl)ethanone and 1-(4-bromo-1-hydroxynaphthalen-2-yl)ethanone with propane-1,3-diamine and pentane-1,3-diamine. The structural analysis is done by UVvis., FT-IR, 1H NMR, 13C NMR, LCMS and elemental analyses. These compounds were assayed for antibacterial (Escherichia coli and Salmonella Typhi) activity and antioxidant (2,2-Diphenyl-1-Picryl Hydrazyl(DPPH) and Hydroxyl radical scavenging method) activity. The antibacterial and antioxidant activities of synthesized Schiff bases exhibited better degrees of inhibitory effects. Among these, Schiff base 2,2'-((propane-1,3-diylbis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(4-chloronaphthalen-1-ol) (II) exhibited excellent antibacterial activity with MICs of 0.12, 0.25, 0.5 and 1 mg/ml against E. coli and Salmonella Typhi. Furthermore, two Schiff bases such as, 2,2'-((propane-1,3-diylbis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(naphthalen-1-ol) (I) and 2,2'-((pentane-1,3-diylbis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(4-bromonaphthalen-1-ol) (IV) exhibited promising antioxidant activity.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, spectroscopic studies and biological evaluation of Schiff bases derived from 1–hydroxy-2-acetonapthanone

Vhanale

Deshmukh

Shinde

2019

Heliyon

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“…[ 25,26 ] Many metal‐based complexes have been used to mimic several enzymes, for example, superoxide dismutase, catalase, and so on. [ 27–30 ]…”

Section: Introductionmentioning

confidence: 99%

“…[25,26] Many metal-based complexes have been used to mimic several enzymes, for example, superoxide dismutase, catalase, and so on. [27][28][29][30] The formation and characteristics of mixed-ligand complexes have received much attention, as they represent new materials for enhancement biological and catalytic features. Thus, based on the aforementioned facts, an attempt has been made to design new mixed-ligand complexes with good biological and catalytic properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

Abdou

Abdel‐Mawgoud

2022

Applied Organom Chemis

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The present paper deals with synthesis new mononuclear 1:1:1 metal:ligand:co‐ligand complexes, FeLG, NiLG, and CuLG, where L = 1‐{(E)‐[(4‐methylphenyl)imino]methyl}‐2‐naphthol and G = Glycine. The synthesized complexes were characterized based on elemental analysis, Fourier transform infrared spectroscopy (FT‐IR), ultraviolet–visible (UV–vis), mass spectra, molar conductance, magnetic susceptibility, and thermal analysis (TGA) in addition to stoichiometry determination via molar ratio method. The isolated metal complexes showed interesting geometry variation as tetrahedral for CuLG and octahedral for both FeLG and NiLG. The molecular structures of the titled compounds were optimized theoretically using density functional theory (DFT) approach, and the quantum chemical descriptors were calculated. The disk diffusion method was used to investigate the growth inhibition of the titled compounds aganist selected pathogenic bacterial and fungal strains. The metal complexes exhibited higher enhancement as antimicrobial candidates with lower minimum inhibitory concentration (MIC) than the free ligands, and in some cases, the complexes were closed to the standard species. Molecular docking investigation was carried out to ascertain the inhibitory action of the studied compounds against 1HNJ protein, the target enzyme for the antimicrobial agents. The results indicated that the FeLG has the highest binding affinity in comparison with other compounds. Thus, these molecules could be promising antimicrobial candidates. Furthermore, catalase mimicking activity of the complexes has been investigated. The data revealed that CuLG complex catalyzes the decomposition of hydrogen peroxide most effectively. Finally, the quantum chemical parameters of the titled complexes and other different compounds were correlated with their practical biological activity data in a trial to build a SAR model.

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“… 5 For example, atmospheric dioxygen is used by catechol oxidase, a type-3 di-copper enzyme, for the oxidation of catechols to ortho -quinones. 6 A variety of di-copper( ii ), di-nickel( ii ) and manganese( ii / iii ) containing functional models of these metalloenzymes have been shown to mediate such catechol oxidation. 7 Phenoxazinone synthase, another multicopper oxidase enzyme, is known to catalyze the oxidative condensation of two molecules of a substituted o -aminophenol to the phenoxazinone chromophore.…”

Section: Introductionmentioning

confidence: 99%

One pot synthesis of two cobalt(iii) Schiff base complexes with chelating pyridyltetrazolate and exploration of their bio-relevant catalytic activities

et al. 2018

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Manganese(III) complexes with tetradentate salicylaldimine Schiff bases: Synthesis, structure, self assembly and catalase activity

Cited by 32 publications

References 40 publications

Synthesis, characterization, spectroscopic studies and biological evaluation of Schiff bases derived from 1–hydroxy-2-acetonapthanone

Synthesis, characterization, spectroscopic studies and biological evaluation of Schiff bases derived from 1–hydroxy-2-acetonapthanone

Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

One pot synthesis of two cobalt(iii) Schiff base complexes with chelating pyridyltetrazolate and exploration of their bio-relevant catalytic activities

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