Manganese induced apoptosis in haematopoietic cells of Nephrops norvegicus (L.)

Hypoxia acclimation protects against oxidative damage and changes in prolactin and somatolactin expression in silver catfish (Rhamdia quelen) exposed to manganese

“…In addition, Mn exposure reduced the hematocrit of the normoxia-acclimated group, while this metal exerted no effects on the hematocrit of the hypoxia group. In the same way, endorsing this finding, Oweson et al (2006) showed Mn-induced apoptosis in hematopoietic cells, which might contribute to the decrease of red blood cells (RBC). However, in the current study, the influence of this exposure was prevented by hypoxia.…”

“…Aquatic environmental pollution is estimated with stationary species, which are considered important bioindicators (Oweson et al, 2006). However, some non-stationary fish species may also reflect the environmental contamination by pollutants.…”

Manganese: A New Emerging Contaminant in the Environment

“…Recent studies showed that high levels of manganese affect Nephrops norvegicus haemocytes causing: i) apoptosis-induced reduction of the number of circulating haemocytes ; ii) inhibition of their maturation to granular haemocytes; iii) inhibition of the recruitment of haematopoietic stem cells (Hernroth et al, 2004;Oweson et al, 2006). These immune suppressive effects were also found in Mytilus edulis (Oweson et al, 2009).…”

Manganese Inhibits Viability of Prostate Cancer Cells

“…Deng et al showed that Mn exposure of cultured astrocytes from rats inhibits cell viability, elevates the level of lactate dehydrogenase (LDH) leakage, and induces G 0 /G 1 phase arrest and apoptosis (8). Studies on the arthropod Nephrops norvegicus have demonstrated that an excess of Mn inhibits proliferation of hematopoietic stem cells and induces apoptosis of these precursor cells (9). The literature is sparse on how overexposure to this trace metal affects human cells but some toxicological studies have been conducted.…”