Manganese-induced neurotoxicity and the potential protective effects of lipoic acid and<i>Spirulina platensis</i>

Ibrahim, Fatma; Nomier, Mahmoud; Sabik, Laila M. E.; Shaheen, Mohamed A.

doi:10.1080/15376516.2020.1771803

Cited by 12 publications

(7 citation statements)

References 92 publications

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“…An effect that was demonstrated to be mediated by the induction of caspase 3 gene expression in a similar rat model of lead-induced neurotoxicity, using spirulina maxima [ 56 ]. Spirulina platensis also demonstrated a neuroprotective activity in other neurotoxic paradigms, in particular in sodium fluoride and manganese treated animals, always associating the protective activity to an antioxidant effect [ 57 , 58 ]. The neuroprotective antioxidant activity of spirulina has also been demonstrated more directly in models of cerebral ischemia-reperfusion injury in rats.…”

Section: Spirulina and Brain Health: In Vivo Evidence And Related Mechanism Of Actionmentioning

confidence: 99%

Spirulina Microalgae and Brain Health: A Scoping Review of Experimental and Clinical Evidence

Sorrenti

Castagna²,

Fortinguerra

et al. 2021

Marine Drugs

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Spirulina microalgae contain a plethora of nutrient and non-nutrient molecules providing brain health benefits. Numerous in vivo evidence has provided support for the brain health potential of spirulina, highlighting antioxidant, anti-inflammatory, and neuroprotective mechanisms. Preliminary clinical studies have also suggested that spirulina can help to reduce mental fatigue, protect the vascular wall of brain vessels from endothelial damage and regulate internal pressure, thus contributing to the prevention and/or mitigating of cerebrovascular conditions. Furthermore, the use of spirulina in malnourished children appears to ameliorate motor, language, and cognitive skills, suggesting a reinforcing role in developmental mechanisms. Evidence of the central effect of spirulina on appetite regulation has also been shown. This review aims to understand the applicative potential of spirulina microalgae in the prevention and mitigation of brain disorders, highlighting the nutritional value of this “superfood”, and providing the current knowledge on relevant molecular mechanisms in the brain associated with its dietary introduction.

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Section: Spirulina and Brain Health: In Vivo Evidence And Related Mechanism Of Actionmentioning

confidence: 99%

Spirulina Microalgae and Brain Health: A Scoping Review of Experimental and Clinical Evidence

Sorrenti

Castagna²,

Fortinguerra

et al. 2021

Marine Drugs

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“…Spirulina platensis (SP) is a type of cyanobacteria that thrives in warm, alkaline freshwater lakes [9]. Several studies have shown that SP has potential benefits for brain health [9][10][11]. It has antioxidant, anti-inflammatory, and neuroprotective properties [9,10,12].…”

Section: Introductionmentioning

confidence: 99%

“…It has antioxidant, anti-inflammatory, and neuroprotective properties [9,10,12]. It mitigates mental fatigue via preventing endothelial damage to cerebral blood vessels [10,11]. Additionally, it improves motor, language, and cognitive skills [13].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Evaluating the neuroprotective effect of Spirulina platensis–loaded niosomes against Alzheimer’s disease induced in rats

Abdelghany

Gamal

Abdel‐Wahab

et al. 2023

Drug Deliv. and Transl. Res.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is characterized by memory loss, changes in behavior, and avoidance of social bonds. Aluminum is one of the main risk factors in the development of AD. Spirulina platensis (SP) is a microalga that improves motor and cognitive skills and prevents cerebral endothelial damage. SP could be delivered in a more controlled and targeted manner using nanoparticles like niosomes. The purpose of this research was to develop a SP-loaded niosome (SPLN) formulation as a drug delivery system to investigate the effectiveness and toxicity of SP as an AD therapy using the AlCl3-induced AD rat model. A niosomal formulation that consists of Tween 60, cholesterol, and dihexadecyl phosphate in a molar ratio of 1:2:0.1 was chosen as an optimum formulation. AD was induced in rats by orally administering AlCl3. Compared with the AlCl3 control, the group treated with the SPLN formulation showed enhancement of the recognition and working memories by increasing the difference score, the discrimination ratio, and the spontaneous alternation behavior. Additionally, it revealed a significant increase in AchE genes, restored the reduced brain neurotransmitters, and improved brain oxidative status. In conclusion, SPLN formulation could be considered an effective AD therapy. Graphical Abstract

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“…In this study, SP supplementation increased spatial learning but had no effect on memory retention. There are limited studies showing the positive effects of SP on learning and memory in stress, schizophrenia, and neurotoxicity models in rats (Haider et al, 2021; Ibrahim et al, 2020; Moradi‐Kor et al, 2019). There are no studies on the effect of SP on learning and memory in HFD.…”

Section: Discussionmentioning

confidence: 99%

The effects of Spirulina platensis on behavior in adolescent rats fed a high‐fat diet

Usluel,

Acikgoz,

Dalkiran

et al. 2023

Intl J of Devlp Neuroscience

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In recent years, childhood overweight and obesity have become a universal public health problem. Obesity may lead to cognitive disorders, depression and anxiety by affecting neuronal processes. Spirulina platensis (SP), a species of microalgae from the Chlorophyceae green algae class, has neuroprotective effects and may reduce body weight. In this study, we aimed to investigate the effects of SP on behavior alongside the role of leptin and Sirtuin‐1 in fed with high‐fat diet (HFD) adolescent rats. Four‐week‐old Sprague Dawley male rats were divided into four groups: control, HFD, HFD + SP150 (150 mg/kg/day SP, orally), HFD + SP450 (450 mg/kg/day SP, orally). Rats except for the control group exposed to 60% HFD along 12 weeks. Last 6 weeks SP or vehicle administered. After the behavioral tests, leptin and Sirtuin‐1 levels in prefrontal cortex and hippocampus regions were evaluated. SP150 significantly reduced body weight compared with HFD group. The time spent in the center of open field increased significantly in SP150‐treated rats compared with HFD. SP150 and SP450 significantly decreased immobility time in forced swim test compared with HFD. Leptin levels in HFD group were significantly lower in prefrontal cortex compared to control group. Leptin levels of the HFD + SP450 group were significantly higher than HFD group in the hippocampus. There was no significant difference between groups in Sirtuin‐1 levels. In conclusion, SP supplementation in adolescence period might positively affect chronic high fat‐induced anxiety‐like and depressive‐like behavior by partially affecting brain leptin levels and without affecting Sirtuin‐1 levels.

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Manganese-induced neurotoxicity and the potential protective effects of lipoic acid andSpirulina platensis

Abstract: At the end of the experiment, the neurobehavioral tests (sucrose preference, Morris water maze, inverted screen test) were done.The final body weight of each rat was recorded for evaluating the body weight changes.

Cited by 12 publications

References 92 publications

Spirulina Microalgae and Brain Health: A Scoping Review of Experimental and Clinical Evidence

Spirulina Microalgae and Brain Health: A Scoping Review of Experimental and Clinical Evidence

RETRACTED ARTICLE: Evaluating the neuroprotective effect of Spirulina platensis–loaded niosomes against Alzheimer’s disease induced in rats

The effects of Spirulina platensis on behavior in adolescent rats fed a high‐fat diet

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