Manganese inhibits benzoyl peroxide/copper-dependent lipid peroxidation in the microsomal fraction of rabbit dental pulp

Abstract

1. Of all the cations tested only manganese ion inhibited the benzoyl peroxide/Cu2+-dependent formation of thiobarbituric acid (TBA)-reactive substance. 2. Ki of Mn2+ for the formation of TBA-reactive substance was 5.0 microM. 3. The inhibitory manner of manganese was non competitive against copper.

Pro- or anti-oxidant manganese: a suggested mechanism for reconciliation

“…In mammalian tissues, Mn 2+ inhibits iron-induced lipid peroxidation and dopamine depletion (Sziraki et al, 1995(Sziraki et al, , 1998. The reduction of copper-dependent low-density lipoprotein conjugation (Tsujimoto et al, 1988), and iron-induced phospholipid peroxidation, by Mn 2+ has also been demonstrated in mammalian cultured cells (Tampo and Yonaha, 1992).…”