Manganese levels during pregnancy and at birth: relation to environmental factors and smoking in a Southwest Quebec population

Takser, Larissa; Lafond, Julie; Bouchard, Maryse F.; St-Amour, Geneviève; Mergler, Donna

doi:10.1016/j.envres.2003.11.002

Cited by 118 publications

(137 citation statements)

References 28 publications

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“…In the rural study cohort, Mn was also measured in the respective umbilical cord blood samples, and the Mn levels in cord bloods were found to be double those found in the respective maternal samples. These findings are in agreement with the outcomes of the pilot of this study and other investigations, except that no significant correlation was found between maternal and the respective cord blood Mn levels, as has been reported in other studies 12,30 . Some studies have found some correlation between maternal MnB levels and birth outcomes such as birth weight and head circumference; however, these correlations were not evident in the current study cohort 15.31 .…”

Section: Discussionsupporting

confidence: 94%

“…Overall, the present study found MnB concentrations in South African women at delivery to be comparable with MnB levels in similar populations residing in industrial settings of Canada (GM 14.6 µg/L), Australia (mean 13 µg/L), Sweden (GM 12 µg/L) and Norway (GM 10.7 µg/L) 30,22,23,20 . However, these concentrations were much lower than those reported in comparable studies from China (mean 55 µg/L) and France (mean 23 µg/L) 31,32 .…”

Section: Discussionsupporting

confidence: 77%

“…Mn levels at different stages of pregnancy were not reported in the current study. However, studies have shown that Mn levels are found to be at their highest at delivery and postpartum, and are an indication of prenatal exposure 20,30 .…”

Section: Discussionmentioning

confidence: 99%

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Prenatal exposure to manganese in South African coastal communities

Röllin

Kootbodien

Theodorou

et al. 2014

Environ. Sci.: Processes Impacts

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Exposure to environmental sources and altered physiological processes of manganese uptake during pregnancy and its possible effect on prenatal and postnatal development are of concern. This study investigates manganese blood levels at the time of delivery across four cohorts of pregnant women residing in coastal communities of South Africa and examines birth outcomes and environmental factors that could influence manganese levels in the study population. The geometric mean (GM) manganese blood levels (MnB) for all women at delivery was 15.2 µg/L. Collectively, rural women reported higher MnB concentrations (GM, 16.1 µg/L) than urban women (GM, 13.5 µg/L, p<0.001). Of the 302 cord blood samples drawn from the study participants (rural women only), GM MnB levels reported for three rural sites were 25.8 µg/L (Rural 1), 33.4 µg/L (Rural 2) and 43.0 µg/L (Rural 3) and were twice as high as their respective maternal levels. However, no significant correlations were found between maternal and cord MnB levels across the 3 study areas. Factors associated 2 with elevated maternal MnB levels, after adjusting for gestational age were: women living in a rural area (Rural 2) (p = 0.021); women drinking potable water from an outdoor/communal tap sourced from municipality (p = 0.021); drinking water from river/stream (p = 0.036); younger maternal age (p = 0.026); consuming leafy vegetables once a week (p = 0.034); and elevated maternal blood lead concentrations (PbB) (p = 0.002). The results indicate that a MnB concentration in rural women during pregnancy is higher compared to urban women and increases with manganese intake from food and water.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 77%

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Prenatal exposure to manganese in South African coastal communities

Röllin

Kootbodien

Theodorou

et al. 2014

Environ. Sci.: Processes Impacts

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“…Mn maintains the blood glucose level in normal range and hence is useful in treating diabetes and hypo-glycemia [19]. The recommended Mn levels required for the develop-ment of normal insulin synthesis and secretion are 2.5 to 5 mg/day [20]. The toxic metals, lead (Pb) and cadmium (Cd), are ubiquitous en-vironmental toxins that are related to a broad range of physiologic, biochemical, and behavioural dysfunctions [21].…”

Section: Introductionmentioning

confidence: 99%

Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients

Afridi

Kazi

Brabazon

et al. 2013

Clinica Chimica Acta

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Background: The essential metals, chromium (Cr), magnesium (Mg), manganese (Mn) and zinc (Zn), are necessary for many metabolic processes and their homeostasis is crucial for life. The toxic metals, cadmium (Cd) and lead (Pb), have no beneficial role in human metabolism. The aim of this study was to investigate the levels of Cd, Cr, Mg, Mn, Pb, and Zn in scalp hair samples of type 2 diabetes mellitus patients of both genders, ages ranging from 30 to 50 y, and belong to urban areas of Ireland and Pakistan. For comparison purposes, age matched non-diabetic subjects of both countries were selected as referents. Methods: The concentrations of metals in scalp hair samples were measured by inductively coupled plasma atomic emission spectrophotometer and atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by conventional wet-acid-digestion method and using certified reference materials. Results: The mean values of Cd and Pb were significantly higher in scalp hair samples of both Pakistani and Irish diabetic patients as compared to referents of both countries (P<0.001). In contrast, lower Cr, Mg, Mn, and Zn (P<0.01) concentrations were detected in scalp hair derived from patients with type 2 diabetes versus healthy subjects of both countries. Conclusion: This study showed that, increased toxic elements and decreased essential elements are associated with diabetes mellitus. Therefore, these elements may play a role in the development and pathogenesis of diabetes mellitus.

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“…During pregnancy, the fetus is relatively protected from free radicals in the uterine environment, but faces increased oxidative action at birth (4) . Antioxidant status of the newborn is influenced by maternal dietary intake (5)(6)(7)(8)(9)(10)(11) . The health implications of antioxidant supply during early life are a relatively novel field of research.…”

mentioning

confidence: 99%

Sociodemographic and lifestyle characteristics are associated with antioxidant intake and the consumption of their dietary sources during pregnancy

Uusitalo

Ovaskainen

et al. 2008

Public Health Nutr.

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Objective: To analyse the associations of selected sociodemographic and lifestyle factors with the intake of antioxidant nutrients and consumption of their main dietary sources among pregnant women. Design: A population-based cohort study. Dietary intake during pregnancy was assessed by a self-administered FFQ one to three months after the delivery. Setting: Type 1 Diabetes Prediction and Prevention (DIPP) Project. Subjects: Subjects comprised 3730 women (70?1 % of those invited) who entered the DIPP Nutrition Study after delivering a child at increased genetic risk for type 1 diabetes at the university hospitals in Oulu and Tampere, Finland, 1997Finland, -2002. Results: All sociodemographic and lifestyle factors studied showed significant associations with antioxidant intake in multiple regression models adjusting for all other factors. Older and more educated women tended to have higher intake of most antioxidants. Parity was positively associated with retinol intake and inversely with vitamin C intake. Smokers had lower intakes of most antioxidants. Only the partner's education was positively associated with high intake of fruits, whereas own education was positively associated with berry consumption. Vegetable consumption was positively associated with partner's education except for women with academic education, who tended to have high vegetable consumption irrespective of partner's education. Conclusions: Young women, smokers and those with a low education are at risk for low antioxidant intake and non-optimal food choices during pregnancy.

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Manganese levels during pregnancy and at birth: relation to environmental factors and smoking in a Southwest Quebec population

Cited by 118 publications

References 28 publications

Prenatal exposure to manganese in South African coastal communities

Prenatal exposure to manganese in South African coastal communities

Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients

Sociodemographic and lifestyle characteristics are associated with antioxidant intake and the consumption of their dietary sources during pregnancy

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