Manganese mitigates against hepatorenal oxidative stress, inflammation and caspase-3 activation in rats exposed to hexachlorobenzene

Tijani, Abiola S; David, O; Farombi, Ebenezer O.

doi:10.1080/01480545.2021.1986061

Cited by 3 publications

(1 citation statement)

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“…4 Several studies have reported that prolonged exposure to HCB can induce neurotoxic, immunotoxic, hepatorenotoxic, dermal, thyroid and reproductive toxic effects in animals and humans. 5,7 Also, significant decrease in male sex hormones, sperm count, motility and viability accompanied by epididymal and testicular histological damage have been reported with HCB. 4,8 These male reproductive disorders could be associated to excessive generation of free reactive oxygen species (ROS), increased lipid peroxidation, inflammation and apoptosis in the testis induced by HCB.…”

Section: Introductionmentioning

confidence: 99%

Thymol co-administration abrogates hexachlorobenzene-induced reproductive toxicities in male rats

2023

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This present study was designed to investigate ameliorating potential of thymol (THY) on hexachlorobenzene (HBC)-induced epididymal and testicular toxicities in adult male rats. Forty adult male rats were orally treated by gavage daily for 28 consecutive days and divided into four groups; control group administered with corn oil, HBC-treated group (16 mg/kg b. wt), thymol-treated group (30 mg/kg b. wt), and HBC + THY-treated group. The results revealed that HBC exposure caused a significant decrease in the body weight change, organ weights, sperm functional parameters, serum testosterone level with widespread histological abnormalities. Furthermore, HBC-treated rats showed increased in the serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), epididymal and testicular myeloperoxidase activity, tumor necrosis-α, interleukin-1β level and caspase-3 activity, induced oxidative damage as evidenced by elevated malondialdehyde (MDA), reactive oxygen species (RONS) levels and significant reduction in antioxidant enzyme activities and reduced glutathione (GSH). However, co-treatment of THY with HBC alleviated the HBC-induced epididymal and testicular toxicities. Our findings revealed that HBC acts as a reproductive toxicant in rats and thymol could be a potential remedial agent for HBC-induced reproductive toxicity.

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Section: Introductionmentioning

confidence: 99%