Manganese superoxide dismutase: beyond life and death

Holley, Aaron K.; Dhar, Subhra; Xu, Yong; Clair, Daret K. St.

doi:10.1007/s00726-010-0600-9

Cited by 105 publications

(88 citation statements)

References 218 publications

(270 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Along with our in vitro data (346) on cytoxic effects of MnPs through H 2 O 2 production when combined with ascorbate, several other groups reported that overexpression of MnSOD kills tumors through H 2 O 2 production (101,130,152,190). We hope that future studies will provide deeper insight into anti-vs. prooxidative actions of compounds (endogenous or exogenous) that are presently primarily considered antioxidants.…”

Section: Cancersupporting

confidence: 72%

“…Breast cancer. Because (a) MnSOD (the essential endogenous antioxidant) is reduced in many cancers; (b) increased expression of MnSOD inhibits cancer growth (152), and (c) SOD mimic, MnTE-2-PyP 5þ enters mitochondria (306), it is only logical that we tested the possible anticancer activity of MnTE-2-PyP 5þ . Three studies from our group were done within the last 8 years (with doses of MnTE-2-PyP 5þ ranging from 6 to 15 mg=kg) with the goal to prove if and why a catalytic SOD mimic=peroxynitrite scavenger would exert anticancer effects [i.e., to evaluate whether the attenuation of the oxidative stress by MnTE-2-PyP 5þ could suppress tumor growth in a 4T1 mouse breast tumor model (222,221,259)].…”

Section: Cancermentioning

confidence: 99%

See 1 more Smart Citation

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

Batinić‐Haberle

Rebouças

Spasojević

2010

Antioxidants & Redox Signaling

470

689

View full text Add to dashboard Cite

Oxidative stress has become widely viewed as an underlying condition in a number of diseases, such as ischemia-reperfusion disorders, central nervous system disorders, cardiovascular conditions, cancer, and diabetes. Thus, natural and synthetic antioxidants have been actively sought. Superoxide dismutase is a first line of defense against oxidative stress under physiological and pathological conditions. Therefore, the development of therapeutics aimed at mimicking superoxide dismutase was a natural maneuver. Metalloporphyrins, as well as Mn cyclic polyamines, Mn salen derivatives and nitroxides were all originally developed as SOD mimics. The same thermodynamic and electrostatic properties that make them potent SOD mimics may allow them to reduce other reactive species such as peroxynitrite, peroxynitrite-derived CO 3 _ À , peroxyl radical, and less efficiently H 2 O 2 . By doing so SOD mimics can decrease both primary and secondary oxidative events, the latter arising from the inhibition of cellular transcriptional activity. To better judge the therapeutic potential and the advantage of one over the other type of compound, comparative studies of different classes of drugs in the same cellular and=or animal models are needed. We here provide a comprehensive overview of the chemical properties and some in vivo effects observed with various classes of compounds with a special emphasis on porphyrin-based compounds. Antioxid. Redox Signal. 13, 877-918.

show abstract

Section: Cancersupporting

confidence: 72%

Section: Cancermentioning

confidence: 99%

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

Batinić‐Haberle

Rebouças

Spasojević

2010

Antioxidants & Redox Signaling

470

689

View full text Add to dashboard Cite

show abstract

“…Furthermore, Mn-SOD influences the activity of transcription factors (such as HIF-1α, AP-1, NF-κB and p53) and affects DNA stability [35]. A critical role of Mn-SOD under physiological and pathological conditions has recently been reviewed in details and the following findings of Mn-SOD confirm the critical role of Mn-SOD in the survival of aerobic life [36][37][38][39]:…”

Section: Superoxide Dismutase In Biological Systemsmentioning

confidence: 85%

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Surai¹

2016

J Anim Res Nutr

168

135

View full text Add to dashboard Cite

Commercial poultry production is associated with various stresses responsible for decreasing productive and reproductive performance of growing chicks, breeders and commercial layers. A growing body of evidence shows that most of stresses in poultry production at the cellular level are associated with oxidative stress. Recently, a concept of the cellular antioxidant defense has been revised with special attention paid to cellular redox status maintenance and cell signaling. In fact, antioxidant systems of the living cell are based on three major levels of defense and superoxide dismutase (SOD) is shown to belong to the first level of the antioxidant defense network. Cellular antioxidant defenses are shown to include several options and vitagene activation in stress conditions is considered as a fundamental adaptive mechanism. The vitagene family includes various genes regulating synthesis of protective molecules including thioredoxins, sirtuins, heat shock proteins and SOD. However, by the time of writing no comprehensive review on the roles and effects of SOD in poultry biology has appeared. Therefore, the aim of this review is a critical analysis of the role of SOD in poultry biology with specific emphasis to its functions as an essential part of the vitagene network. From the analysis of the recent data related to SOD in poultry physiology and adaptation to stresses it is possible to conclude that: a) SOD as important vitagene is the main driving force in cell/body adaptation to various stress conditions. Indeed, in stress conditions additional synthesis of SOD is an adaptive mechanism to decrease ROS formation; b) If the stress is too high SOD activity is decreased and apoptosis is activated; c) there are tissue-specific differences in SOD expression which also depends on the strength of such stress-factors as heat, heavy metals, mycotoxins and other stressors; d) SOD is shown to provide an effective protection against lipid peroxidation in chicken embryonic tissues and semen; e) SOD is shown to be protective in heat and cold stress, toxicity stress as well as in other oxidative-stress related conditions in poultry production; f) there are complex interactions inside the antioxidant network of the cell/body to ensure an effective maintenance of homeostasis in stress conditions. Indeed, in many cases, nutritional antioxidants (vitamin E, selenium, carotenoids, phytochemicals, etc.) in the feed can increase SOD expression; g) nutritional means of SOD upregulation in stress conditions of poultry production and physiological and commercial consequences await further investigation; h) vitagene upregulation in stress conditions is emerging as an effective means for stress management.

show abstract

“…Disruption of the MnSOD gene in mice has been -toc: -tocoferol; Cyt c3+ (reduced cytochrome c) ; CuZnSOD: copper-zinc superoxide dismutase; Gpx: glutathione peroxidase; GSH: reduced glutathione, GSSG: oxidized glutathione; L-Arg: L-arginine; mtNOS: mitochondrial nitric oxide synthase, NO: nitric oxide; Prx3-(SH) 2 : peroxiredoxine 3 reduced, Prx3-S 2 : peroxiredoxine 3 oxidized; ROS: reactive oxygen species, RNS: reactive nitrogen species; Trx2-(SH) 2 : tioredoxine 2 reduced, Trx2-S 2 : tioredoxine oxidized. associated with early postnatal lethality (Li et al, 1995), while MnSOD overexpression was shown to protect mitochondrial function and block apoptosis (Holley et al, 2010). The activity of MnSOD should be coordinated with H 2 O 2 -removing enzymes.…”

Section: Enzymatic Antioxidantsmentioning

confidence: 99%