Manganese superoxide dismutase genotypes and asbestos-associated pulmonary disorders

Hirvonen, Ari; Tuimala, Jarno; Ollikainen, Tiina; Linnainmaa, Kaija; Kinnula, Vuokko L.

doi:10.1016/s0304-3835(01)00819-9

Cited by 32 publications

(23 citation statements)

References 14 publications

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“…41 Only 1 study investigated before the role of MnSOD polymorphism for the risk of mesothelioma, however the number of patients (20 MPM) was limited and no significant association was found. 42 In this study GSTM1 null allele also appeared to be a risk factor for MPM. This is in agreement with previous findings obtained on a smaller study group from Finland 14 and on a partially overlapping Italian study group.…”

Section: Discussionsupporting

confidence: 50%

Polymorphisms of glutathione‐S‐transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesothelioma

Landi

Gemignani

Neri

et al. 2007

Intl Journal of Cancer

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Individual response to oxidative stress, due to exposure to asbestos fibres plays a significant role in the malignant pleural mesothelioma (MPM) etiology. The differential impact on MPM risk of polymorphic alleles of glutathione-S-transferases (GSTs) and manganese superoxide dismutase (MnSOD/SOD2) genes involved in the defence against oxidative damage has been investigated. Ninety cases of MPM and 395 controls were genotyped using the arrayed-primer extension technique. Logistic regression analysis was applied to assess the predictive role of single nucleotide polymorphisms (SNPs) potentially involved in MPM carcinogenesis after adjustment for potential confounders. An increased risk of MPM was found in subjects bearing a GSTM1 null allele (OR 5 1.69, 95% CI 5 1.04-2.74; p 5 0.034), and in those with the Ala/Ala genotypes at codon 16 within MnSOD (OR 5 3.07, 95% CI 5 1.55-6.05; p 5 0.001). A stronger effect of MnSOD was observed among patients without a clear exposure to asbestos fibres. No effect was found for GSTA2, GSTA4, GSTM3, GSTP1 and GSTT1 genes. These findings, if replicated, contribute substantial evidence to the hypothesis that oxidative stress and cellular antireactive oxygen species systems are involved in the pathogenesis and in the natural history of MPM. ' 2007 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 50%

Polymorphisms of glutathione‐S‐transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesothelioma

Landi

Gemignani

Neri

et al. 2007

Intl Journal of Cancer

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“…The frequencies of TT, CT, CC genotypes were found to be 32.5%, 50.5% and 17.5% in the controls respectively. The frequency distributions of C and T alleles were found to be respec- has the similar CC genotype frequency as seen in AfricanAmerican [35], Finn [36], and Italian populations [37]. We detected considerably lower CC genotype frequency than those found in Korean [38], Japan [39], Chinese [40] and Taiwan [41] populations and higher frequencies than those found in American [23], Polish [42], Danish [43], German [44] and Russian [45] populations.…”

Section: Resultssupporting

confidence: 75%

Manganese-Superoxide Dismutase (MnSOD) Polymorphisms

Siliğ

Taş²,

Pınarbaşı³

2015

Turk J Bioch

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Objective: Manganese superoxide dismutase (MnSOD,SOD2), the only known superoxide scavenger in mitochondria, may be particularly important for antioxidant defense because mitochondria are the major sites for cellular metabolism and hence production of reactive oxygen species. Methods: In this study, 440 Turkish individuals were genotyped for polymorphisms of SOD2 gene. The distribution of these polymorphisms in this population was examined using a PCR-RFLP method. Results: In the present study, a total of 440(females: 201, 46% and males: 239, 54%) healthy individuals were studied. The mean age of the study population was 54,41±5,76 years (males, 55,34±5,76; females, 53,12±7,16 and males: 239, 54%) unrelated healthy volunteers from central Anatolia. There was no age and sex restriction for selection of the healthy volunteers, who were free of any chronic diseases, living in the same geographic area, and having no history of any cancer. We attempted to include all the control studies published to data on the SOD2 rs4880 polymorphism. DNA isolationTwo milliliters peripheral blood samples were collected in to citrate containing tubes from all subjects. DNA was extracted from whole blood by salting out procedure as soon as the samples reached to laboratory [19]. GenotypingThe distribution of these polymorphisms was examined using a PCR-RFLP method. For amplifying the SOD2 rs4880 polymorphism, forward primer 5'-ACC AGC AGG CAG CTG GCG CCG G-3' and reverse primer 5'-GCG TTG ATG TGA GGT TCC AC-3'were used. PCR reactions contained 0,75 µL (25 pmol/µL) of each primer, 2µL dNTPs (1mmol/L), 1,5µL of 25 mmol/L MgCI2, 1.5 Units of Taq DNA polymerase and 16,2µL sterile deionized water. DNA 50-100 ng is in a total volume of 50 µL. The Statistical analysisAll statistical analyses were performed using the Statistical Package for Social Sciences Program (SPSS, version 11). The Chi-square (X 2 ) test was used to evaluate the association between healthy individuals and SOD genotypes. Genotype, allele frequencies was estimated by counting. Hardy-Weinberg equilibrium between expected and observed genotype distributions was assessed using the X

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“…Twenty-one studies have investigated the relationship between the SOD2 Ala16Val SNP and other cancers (di Martino et al, 2007;Han et al, 2007;Hirvonen et al, 2002;Ho et al, 2006;Hung et al, 2004;Ichimura et al, 2004;Johnatty et al, 2007;Koistinen et al, 2006;Landi et al, 2007;Li et al, 2002;Lightfoot et al, 2006;Lin et al, 2003;Liu et al, 2004;Mak et al, 2007;Martin et al, 2005;Murphy et al, 2007;Sun et al, 2009;Wang et al, 2004Wang et al, , 2006Young et al, 2006;Zejnilovic et al, 2009). Wang et al (2004) found that individuals with the Val allele had an increased risk of lung cancer if there was low or no asbestos exposure compared to high exposure (OR 2.14, 95% CI 1.52-3.01), although the small number in the high asbestos exposure group limited the validity of the findings.…”

Section: Other Cancersmentioning

confidence: 99%

“…Three studies of chronic obstructive pulmonary disease reported no association with the SOD2 genotype (Hirvonen et al, 2002;Mak et al, 2007;Young et al, 2006). The Ala allele is associated with an increased risk of sporadic motor neurone disease, particularly in females (Van Landeghem et al, 1999).…”

Section: Other Conditionsmentioning

confidence: 99%

Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease

Crawford

Fassett

Geraghty

et al. 2012

Gene

151

119

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Manganese superoxide dismutase genotypes and asbestos-associated pulmonary disorders

Cited by 32 publications

References 14 publications

Polymorphisms of glutathione‐S‐transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesothelioma

Polymorphisms of glutathione‐S‐transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesothelioma

Manganese-Superoxide Dismutase (MnSOD) Polymorphisms

Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease

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