Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro

Stelling, Mariana P.; Soares, Mariana Alves; Cardoso, Simone C.; Motta, Juliana María; Abreu, Joice Côrtes de; Antunes, Maria Júlia M; Freitas, Vitória Gonçalves de; Moraes, João Alfredo; Castelo-Branco, Morgana T.; Pérez, Carlos A.; Pavão, Mauro S.G.

doi:10.1038/s41598-021-95190-5

Cited by 4 publications

(2 citation statements)

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“…This research was conducted in two phases: biological experiment ( [29]) and data analysis. For the biological experiment, tissue samples of liver, lung, and primary tumor were collected from C57BL/6 mice.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of elemental profile in distant tissues during tumor progression

Salles

Pavão

et al. 2022

Preprint

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Background: Knowing how cancer develops, progresses, and spreads (metastasis) is required to mobilize the development of new ways to prevent, detect, diagnose and treat cancer. Essential elements present functions in tumor progression, promoting proliferation, migration, among other protumoral cellular processes. Understanding how those elements are related to the processes of tumor progression is of great relevance for research. The study of the elemental profile in distant tissues, which can be modulated by tumor cells to promote metastasis, has not been sufficiently investigated. Therefore, the main objective of this study is to evaluate the distribution of medium to heavy elements during tumor progression, focusing on the tumor tissue and distant tissues that could be affected. Results: With this work, it was possible to observe significant changes in the concentrations’ distribution of P, S, K, Ca, Mn, Fe and Cu in distant tissues caused by the presence of tumor cells. It was also possible to detect a greater similarity between tumor tissue (which has the lung as tissue of origin) and a tissue of non-origin, such as the liver, which is an unprecedented result. Moreover, changes in the distributions of concentrations were detected and studied over time for the different tissues analyzed, such as primary tumor, liver and lung, in Control and Tumor groups. Finally, the importance of elements for biological processes of normal cells, as well as tumor cells during tumor progression was also discussed. Conclusions: This work presents as contributions the study of the elemental profile in tumor and distant tissues. Furthermore, this work evaluates several elements of known biological importance (P, S, K, Ca, Mn, Fe, Cu, and Zn) allowing the study of different biological processes involved in cancer.

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Section: Methodsmentioning

confidence: 99%

“…All procedures involving animal experimentation were approved by the Federal University of Rio de Janeiro Animal Experimentation Committee (protocol number: 015/18) and were performed in accordance with the Brazilian guidelines for scientific use of animals. For more details of the biological experiment refer to the work of Stelling et al [29].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of elemental profile in distant tissues during tumor progression

Salles

Pavão

et al. 2022

Preprint

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Characterization and application of targeted MnO2/CS@ALA-MTX nano-radiosensitizers for boosting X-ray radiotherapy of brain tumors

Ayyami,

Dastgir,

Ghorbani

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Elemental profiles in distant tissues during tumor progression

Salles

Pavão

et al. 2023

BMC Cancer

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Background Essential elements have functions in tumor progression by promoting protumoral cellular processes, such as proliferation, and migration, among others. Obtaining an understanding of how these elements relate to tumor progression processes is of great importance for research. Elemental profile studies in distant tissues, which can be modulated by tumor cells to promote metastasis, have not been sufficiently investigated. The main goal of this study is to evaluate multielemental distribution during tumor progression, focusing on tumor tissue and distant tissues that may be affected. Methods Tumor progression in vivo was simulated by inoculating C57BL/6 mice with Lewis Lung Carcinoma (LLC) cells. Samples of the primary tumor and distant tissues were collected during 5 weeks of tumor progression for the control and experimental (tumor-bearing) groups. The biological samples were analyzed using the synchrotron radiation X-Ray fluorescence technique. Data on the concentration of P, S, K, Ca, Mn, Fe, Cu, and Zn in the samples were obtained and statistically analyzed to evaluate the distribution of the elements during tumor progression in the primary tumor as well as distant tissues. Results It was possible to observe significant changes in the concentrations’ distribution of P, S, K, Ca, Mn, Fe, and Cu in distant tissues caused by the presence of tumor cells. It was also possible to detect a greater similarity between tumor tissue (which has the lung as tissue of origin) and a tissue of non-origin, such as the liver, which is an unprecedented result. Moreover, changes in the distributions of concentrations were detected and studied over time for the different tissues analyzed, such as primary tumor, liver and lung, in Control and Tumor groups. Conclusions Among other results, this paper could explore the modulation of distant tissues caused by the presence of a primary tumor. This could be achieved by the evaluation of several elements of known biological importance allowing the study of different biological processes involved in cancer. The role of essential elements as modulators of the tumor microenvironment is a relevant aspect of tumor progression and this work is a contribution to the field of tumoral metallomics.

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Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro

Cited by 4 publications

References 52 publications

Evaluation of elemental profile in distant tissues during tumor progression

Evaluation of elemental profile in distant tissues during tumor progression

Characterization and application of targeted MnO2/CS@ALA-MTX nano-radiosensitizers for boosting X-ray radiotherapy of brain tumors

Elemental profiles in distant tissues during tumor progression

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