Manganese

Hurley, Lucille S.; Keen, Carl L.

doi:10.1016/b978-0-08-092468-7.50010-7

Cited by 132 publications

(78 citation statements)

References 213 publications

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“…For both C and M infants, liver copper concentrations were almost 10 times higher than typical values reported for adults, whereas manganese concentrations were about half of adult values (1 8,39). This observation is similar to what has been observed for several species including humans (40)(41)(42)(43)(44), and supports the idea that the neonate is born with considerable liver copper stores, whereas the transfer of manganese to the fetus and/or its retention is very low.…”

Section: Discussionsupporting

confidence: 75%

Influence of Marginal Maternal Zinc Deficiency on Pregnancy Outcome and Infant Zinc Status in Rhesus Monkeys

Lönnerdal

et al. 1989

Pediatr Res

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ABSTRACT. To investigate the effects of marginal zinc deficiency on early development, rhesus monkeys were fed a diet marginally deficient in zinc (M, 4 pglg) throughout pregnancy and during the first month of lactation. Despite the low concentration of zinc in the diet, M dams did not develop overt signs of zinc deficiency. However, compared to control dams fed diets adequate in zinc (C; 100 pg Zn/ g), M dams showed a low response to the mitogens concanavalin A and phytohemagglutinin. Pregnancy outcome was similar in the two groups and all of the neonates were judged to be healthy at delivery. From birth until d 30 of age, the infants were closely monitored for signs of zinc deficiency, and at d 30, they were killed and tissues were removed and analyzed for a number of parameters reported to be affected by zinc status. At birth, M infants had low plasma zinc concentrations compared to controls; however, this difference was not observed at d 30. D 30 M infants showed a normal response to the mitogens concanavalin A and phytohemagglutinin, but showed a low response to pokeweed mitogen. Tissue (liver, brain, spleen, kidney, and heart) trace element concentrations were similar in the two groups of infants, as were liver metallothionein concentrations and @Zn uptakelretention by isolated hepatocytes. Infant wt gain was inversely correlated with plasma zinc, liver zinc, and liver metallothionein concentrations in both the M and C groups. These results demonstrate that feeding a diet containing 4 fig zinclg to rhesus monkeys during pregnancy and lactation does not result in marked signs of zinc deficiency, although subtle signs occur in both the mother and infant. The data also support the concept that infant growth is associated with a depletion of tissue zinc stores. (Pediatr Res 26:470-477, 1989)

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Section: Discussionsupporting

confidence: 75%

Influence of Marginal Maternal Zinc Deficiency on Pregnancy Outcome and Infant Zinc Status in Rhesus Monkeys

Lönnerdal

et al. 1989

Pediatr Res

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“…ID is also a known risk factor for metal toxicity (e.g., cadmium, aluminum, lead) (2)(3)(4), with an inverse relationship existing between dietary iron (Fe) content and the gastrointestinal absorption of a host of other metals. Fe also shares similar absorption mechanisms with essential divalent metals, particularly manganese (Mn) (5), and a deficiency of one of these minerals in the diet can lead to excess absorption of the other mineral. For example, high Fe intakes decrease gastrointestinal Mn absorption, whereas ID leads to increased Mn absorption, (6,7).…”

Section: Introductionmentioning

confidence: 99%

Manganese Accumulates in Iron-Deficient Rat Brain Regions in a Heterogeneous Fashion and Is Associated with Neurochemical Alterations

Erikson

Shihabi

Aschner

et al. 2002

BTER

157

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Abstract:Previous studies have shown that iron deficiency (ID) increases brain manganese (Mn), but specific regional changes have not been addressed. Weanling rats were fed one of three semipurified diets: control (CN), iron deficient (ID), or iron deficient/manganese fortified (IDMn+). Seven brain regions were analyzed for Mn concentration and amino acid (glutamate, glutamine, taurine, γ-aminobutyric acid) concentrations. Both ID and IDMn+ diets caused significant (p<0.05) increases in Mn concentration across brain regions compared to CN. The hippocampus was the only brain region in which the IDMn+ group accumulated significantly more Mn than both the CN and ID groups. ID significantly decreased GABA concentration in hippocampus, caudate putamen, and globus pallidus compared to CN rats. Taurine was significantly increased in the substantia nigra of the IDMn+ group compared to both ID and CN. ID also altered glutamate and glutamine concentrations in cortex, caudate putamen, and thalamus compared to CN. In the substantia nigra, Mn concentration positively correlated with increased taurine concentration, whereas in caudate putamen, Mn concentration negatively correlated with decreased GABA. These data show that ID is a significant risk factor for central nervous system Mn accumulation and that some of the neurochemical alterations associated with ID are specifically attributable to Mn accumulation.

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“…Manganese (Mn) is known to be an essential element for the maintenance of normal metabolic and physiological function of terrestrial animals and fish, consisting of growth, reproduction and prevention of skeletal abnormalities (Hurley and Keen, 1987;Lall, 2002).…”

Section: Introductionmentioning

confidence: 99%

Dietary manganese requirement of juvenile yellow catfish Pelteobagrus fulvidraco, and effects on whole body mineral composition and hepatic intermediary metabolism

et al. 2012

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Manganese

Cited by 132 publications

References 213 publications

Influence of Marginal Maternal Zinc Deficiency on Pregnancy Outcome and Infant Zinc Status in Rhesus Monkeys

Influence of Marginal Maternal Zinc Deficiency on Pregnancy Outcome and Infant Zinc Status in Rhesus Monkeys

Manganese Accumulates in Iron-Deficient Rat Brain Regions in a Heterogeneous Fashion and Is Associated with Neurochemical Alterations

Dietary manganese requirement of juvenile yellow catfish Pelteobagrus fulvidraco, and effects on whole body mineral composition and hepatic intermediary metabolism

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