Mange in Rabbits: An Ectoparasitic Disease with a Zoonotic Potential

El-Ghany, Wafaa A. Abd

doi:10.1155/2022/5506272

Cited by 7 publications

(3 citation statements)

References 106 publications

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“…The animals' skin began to exhibit healthy symptoms after the mites died, including the cessation of inflammation-and-hyperkeratosis, the emergence of new-skin-layers, and-the beginning of new hair growth. This occurred at the same time as reports of the effective treatment of rabbit mange 72 . This full recovery was seen after 3 weeks, whereas the ivermectin group's healing continued until the completion of the experiment (4 weeks) without leading to full recovery.…”

Section: Discussionsupporting

confidence: 83%

Egyptian mandarin peel oil's anti-scabies potential via downregulation-of-inflammatory/immune-cross-talk: GC–MS and PPI network studies

Elmaidomy,

Abdel-Maqsoud,

Tammam

et al. 2023

Sci Rep

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The current study investigated the scabicidal potential of Egyptian mandarin peel oil (Citrus reticulata Blanco, F. Rutaceae) against sarcoptic mange-in-rabbits. Analysis of the oil's GC–MS identified a total of 20 compounds, accounting for 98.91% of all compounds found. Mandarin peel oil topical application improved all signs of infection, causing a scabicidal effect three days later, whereas in vitro application caused complete mite mortality one day later. In comparison to ivermectin, histopathological analysis showed that the epidermis' inflammatory-infiltration/hyperkeratosis-had disappeared. In addition to TIMP-1, the results of the mRNA gene expression analysis showed upregulation of I-CAM-1-and-KGF and downregulation of ILs-1, 6, 10, VEGF, MMP-9, and MCP-1. The scabies network was constructed and subjected to a comprehensive bioinformatic evaluation. TNF-, IL-1B, and IL-6, the top three hub protein-coding genes, have been identified as key therapeutic targets for scabies. From molecular docking data, compounds 15 and 16 acquired sufficient affinity towards the three screened proteins, particularly both possessing higher affinity towards the IL-6 receptor. Interestingly, it achieved a higher binding energy score than the ligand of the docked protein rather than displaying proper binding interactions like those of the ligand. Meanwhile, geraniol (15) showed the highest affinity towards the GST protein, suggesting its contribution to the acaricidal effect of the extract. The subsequent, MD simulations revealed that geraniol can achieve stable binding inside the binding site of both GST and IL-6. Our findings collectively revealed the scabicidal ability of mandarin peel extract for the first time, paving the way for an efficient, economical, and environmentally friendly herbal alternative for treating rabbits with Sarcoptes mange.

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Section: Discussionsupporting

confidence: 83%

Egyptian mandarin peel oil's anti-scabies potential via downregulation-of-inflammatory/immune-cross-talk: GC–MS and PPI network studies

Elmaidomy,

Abdel-Maqsoud,

Tammam

et al. 2023

Sci Rep

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“…У кролів псороптоз є одним із найпоширеніших акарозів, збудником якого є кліщі виду Psoroptes cuniculi Delafond, 1859. Хвороба призводить до отитів, порушення функцій шкіри в ділянці вушних раковин, зниження апетиту, інтоксикації, погіршення якості хутра, схудненні, нерідко -смертності молодняку (Swarnakar et al, 2014;Panigrahi et al, 2016;El-Ghany, 2022). Загальне поширення корости серед кролів становило 57,3 % (Chebet et al, 2018).…”

Section: поширення діагностика та лікування акарозних хвороб кролівunclassified

Parasitic diseases of rabbits (distribution, diagnosis and treatment)

Kruchynenko

2023

SMLNUVMB

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This review presents data on the most common causative agents of protozooses, helminthiases, and ectoparasitic diseases of rabbits (Oryctolagus cuniculus, Linnaeus, 1758), which are of interest to veterinarians. Modern methods of diagnosing parasitic diseases in rabbits have been determined. Chemotherapeutic drugs available on the world pharmaceutical market for therapeutic and preventive treatments in rabbits are listed. The main causative agents of protozoan, helminthic, and ectoparasitic diseases of rabbits are considered, considering the modern systematic position of parasites. The features of the distribution of parasitic diseases in Ukraine and the world, according to the data of well-known scientists in the field of veterinary parasitology, are briefly given. Information on the specifics of the use of antiparasitic drugs in the case of animals affected by protozooses, helminths, and ticks is summarized. The work briefly provides information on the most common medicines and chemical combinations that are the active ingredients of these drugs (their chemical names existing in different countries, synonyms, and main pharmacological properties). Information on the dosage and features of the use of antiparasitic agents in the case of rabbit diseases is given following the data of modern scientific literature and the relevant recommendations for their industrial use. During the inspection, it was established that rabbits are most often affected by eimeriosis (coccidiosis). Currently, 15 species of Eimeria spp. have been identified. Young animals (2–6 months) are most susceptible to eimeriosis. The peak of infestation in the territory of Ukraine falls in the spring-summer period. It was found that P. ambiguus is most often detected among helminthiases in rabbits in our country. Rabbits aged 1 to 2 years are most susceptible to these helminths, and the peak of infestation occurs in January. In rabbits, psoroptosis is one of the most common acaroses, the causative agent of which is ticks of the P. cuniculi species. The purpose of this work was to show the current state of rabbits' most common parasitic diseases on the territory of Ukraine and in the world in general, highlight the existing antiparasitic drugs, and summarize information on their use. It has been established that animals with encephalitozoonosis are the most difficult to diagnose and treat. At the same time, there is a wide range of coccidiostats and coccidiolytics for treating rabbits affected by eimeries. For the infestation of animals with helminths, it is appropriate to use benzimidazoles and ivermectins. In the case of acaroses, ivermectin and fungicidal-acaricidal ointments remain effective drugs. The analysis of literary sources will allow for the expansion of the already available data on the spread, prevention, and treatment of parasitic diseases in rabbits. The given information will help ensure the rabbits' veterinary well-being on Ukraine's territory.

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“…Scabies is caused by the infestation of the burrowing mite Sarcoptes scabiei, which is one of the most severe and highly contagious ectoparasitic skin diseases in rabbits with zoonotic importance 1 . In rabbits, the disease is caused by the common mite Sarcoptes scabiei var cuniculi, and the life span of the adult mites in the host's skin is 3-4 weeks 2 .…”

Section: Introductionmentioning

confidence: 99%

Selamectin Spot-on: A Cure for Scabies in Rabbits

Senthil¹,

Arumugam

Padmanaban

et al. 2023

Small Anim. Adv.

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Introduction: Mange in rabbits is a highly contagious zoonotic disease. The disease is caused mainly by Sarcoptes scabiei, Psoroptes cuniculi, Cheyletiella parasitovorax, and Notoedres cati. The most common forms of this disease in rabbits are body and ear mange. Mites infest animals through direct contact with infected animals or contaminated. Case report: An 8-month-old non-descript female rabbit weighing about 700 g was presented to the Teaching Veterinary clinical complex, Mettupalayam, Puducherry, India, with a history of scratching, pruritus and dried crusty lesions on the margins of the ears, snout, around the eyes and legs and patchy hair loss for the past 15 days. Rectal temperature was 38.4°C, heart rate was 210 bpm, respiratory rate was 40 breaths/minute, and the color of the conjunctival mucous membrane was pink. Other signs included inappetence with normal voiding habits and a thin body condition. The collected skin scraping from the affected areas was examined under the microscope with a 10x objective lens, confirming the presence of live motile Sarcoptes spp. Mite species could be determined through the morphological characteristics (adult mites are nearly circular with short legs, and the third and fourth pairs do not project beyond the margin of the body with terminal anus) under the microscopic examination of the skin scrapings. Therefore, 6% selamectin was applied topically on a single spot at the base of the neck. Supportive therapy with multivitamin (vitamin A, D3, E, B12) drops was given orally at 1 ml per day. Conclusion: The rabbit responded well to the treatments within 2 weeks.

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Mange in Rabbits: An Ectoparasitic Disease with a Zoonotic Potential

Cited by 7 publications

References 106 publications

Egyptian mandarin peel oil's anti-scabies potential via downregulation-of-inflammatory/immune-cross-talk: GC–MS and PPI network studies

Egyptian mandarin peel oil's anti-scabies potential via downregulation-of-inflammatory/immune-cross-talk: GC–MS and PPI network studies

Parasitic diseases of rabbits (distribution, diagnosis and treatment)

Selamectin Spot-on: A Cure for Scabies in Rabbits

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