Mangiferin: a review of dietary sources, absorption, metabolism, bioavailability, and safety

Mei, Suhuan; Manivel, Perumal; Battino, Maurizio; Kitts, David D.; Xiao, Jianbo; Ma, Haile; Chen, Xiumin

doi:10.1080/10408398.2021.1983767

Cited by 38 publications

(27 citation statements)

References 128 publications

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“…Mangiferin possesses various bioactivities, including antioxidant, anti-inflammatory, and anticancer activities ( Mei et al, 2021a ); however, the low bioavailability of mangiferin affects its efficacy. Therefore, scientists have encapsulated mangiferin in various nanoparticles to enhance its bioavailability and bioactivities ( Aboyewa et al, 2021 ; Mei et al, 2021b ). In the present study, we loaded mangiferin on the as-prepared ZnO NPs synthesized using CLE under ultrasonication.…”

Section: Resultsmentioning

confidence: 99%

“…However, the poor solubility and bioavailability of mangiferin results in the low efficacy in human body. To solve this problem, scientists have made great efforts to improve the solubility and bioavailability of mangiferin through various methods such as structural modification, loading mangiferin in the nano/micro carriers, or administration of mangiferin with other components ( Mei et al, 2021b ). ZnO NPs have been used as carriers for doxorubicin, curcumin, quercetin, camptothecin, isotretinoin, daunorubicin, barberine, and chlorogenic acid to enhance the cytotoxicity and pH-dependent control release of drug ( Singh et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Zinc oxide nanoparticles synthesized using coffee leaf extract assisted with ultrasound as nanocarriers for mangiferin

Wang

Mei

Manivel

et al. 2022

Current Research in Food Science

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zinc oxide nanoparticles synthesized using coffee leaf extract assisted with ultrasound as nanocarriers for mangiferin

Wang

Mei

Manivel

et al. 2022

Current Research in Food Science

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“…Mangiferin has another isomer existing as isomangiferin, but it has no chiral structure. Moreover, in nature, it has two similar structures: homomangiferin and neomangiferin (Mei et al 2021a). It is a yellow crystalline solid with molecular weight 422 g/mol and melting point at 274 °C (Khurana et al 2017a), and log P 2.73 (Khurana et al 2016b;Ochocka et al 2017).…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

Recent Formulation Advances of Mangiferin

Barakat

Nasr

Ahmed

et al. 2022

Rev. Bras. Farmacogn.

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Nutraceuticals have recently gained interest owing to their valuable contribution in the treatment of several diseases, with high safety margin and low incidence of side effects. However, their efficacy is limited by some challenges, namely poor solubility, low permeability, and, consequently, low bioavailability. Delivery carriers have proven that they can overcome almost all the aforementioned limitations, leading to improvement in the pharmacological efficacy of nutraceuticals. Among the promising nutraceuticals that have currently evoked considerable interest is mangiferin from mango tree, which is a polyphenol exhibiting many favorable pharmacological actions, but unfortunately suffers from poor aqueous solubility and other limitations that lower its bioavailability and halter its efficacy. This review summarizes the pharmacological actions of mangiferin and provides an insight on how delivery carriers for mangiferin (lipidic, vesicular, polymeric, inorganic, and protein nanoparticles, as well as complexes) can overcome its pharmaceutical challenges, hence reflecting on its improved therapeutic effects in treatment of different diseases.

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“…Hence, mangiferin is frequently regarded as a valuable nutritional supplement derived from mango by‐products. However, due to the poor solubility of MGF in both water and oil, its application in functional foods, cosmetics, and pharmaceuticals is severely limited (Mei et al., 2021b). Attempts should be made to design rational delivery systems for improving the solubility, dispersibility, and stability of mangiferin.…”

Section: Introductionmentioning

confidence: 99%

Double emulsion (W/O/W) gel stabilised by polyglycerol polyricinoleate and calcium caseinate as mangiferin carrier: insights on formulation and stability properties

XING

XUE

et al. 2022

Int J of Food Sci Tech

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Mangiferin (MGF) is a phenolic compound isolated from mango, but its poor solubility significantly limits its use. In this study, MGF was embedded into the inner aqueous phase of W 1 /O/W 2 emulsions. Firstly, the dissolution method of MGF was determined. MGF remained stable in solution with pH 13 at 30 min, and its solubility reached 10 mg mL −1 . When the pH of MGF solutions was adjusted from pH 13 to pH 6, MGF did not immediately crystallise, providing sufficient time to construct the MGF-loaded W 1 /O/W 2 emulsions. Subsequently, the MGF-loaded W 1 /O/W 2 emulsions were constructed using polyglycerol polyricinoleate (PGPR) and calcium caseinate (CAS). The formation and stability of the W 1 /O/W 2 emulsions were investigated. The MGF-loaded W 1 /O/W 2 emulsions stabilised with 1% PGPR and 1% -3% CAS exhibited a low viscosity, limited loading capacity, and poor stability. Conversely, the MGFloaded W 1 /O/W 2 emulsions stabilised by 3%PGPR-3%CAS exhibited optimal loading capacity (encapsulation efficiency = 95.31% and loading efficiency = 0.91%) and stability, which was attributed to the fact that high viscosity and gel state retarded the migration of inner aqueous phase. These results indicated that the W 1 /O/W 2 emulsions stabilised by PGPR and CAS may be a potential alternative for encapsulating mangiferin.

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Mangiferin: a review of dietary sources, absorption, metabolism, bioavailability, and safety

Cited by 38 publications

References 128 publications

Zinc oxide nanoparticles synthesized using coffee leaf extract assisted with ultrasound as nanocarriers for mangiferin

Zinc oxide nanoparticles synthesized using coffee leaf extract assisted with ultrasound as nanocarriers for mangiferin

Recent Formulation Advances of Mangiferin

Double emulsion (W/O/W) gel stabilised by polyglycerol polyricinoleate and calcium caseinate as mangiferin carrier: insights on formulation and stability properties

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