Mangiferin stimulates chondrogenic differentiation of mesenchymal stem cells from subchondral bone and targets multiple aspects of smads and SOX9 pathways

Abstract

Purpose: To assess the effect that mangiferin(1), a standard component of WIN-34B, has on chondrogenic differentiation of mesenchymal stem cells(MSCs) from rabbit subchondral bone. Methods: Histological analysis was performed by alcian blue, oil red O, and alizarin red staining to evaluate if progenitor cells from rabbit subchondral bone have chondrogenic, adipogenic, and osteogenic differentiation capacity. Changes in levels of chondrogenic markers type II