2016
DOI: 10.3945/jn.115.226688
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Mango Supplementation Modulates Gut Microbial Dysbiosis and Short-Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6 Mice Fed a High-Fat Diet

Abstract: The addition of mango to an HF diet modulated the gut microbiota and production of SCFAs in C57BL/6 mice; these changes may improve gut tolerance to the insult of an HF diet.

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Cited by 54 publications
(39 citation statements)
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“…Metagenomic studies revealed that the interplay between gut microbiota phylotypes from control and protective donors with HFD in transplanted GFm resulted in an increased detection of Akkermansia genus, that showed an opposite pattern to that previously described in non‐transplanted HFD‐fed mice, which could be explained in terms of different microbiome initial conditions. Interestingly, Akkermansia spp.…”
Section: Discussionmentioning
confidence: 58%
“…Metagenomic studies revealed that the interplay between gut microbiota phylotypes from control and protective donors with HFD in transplanted GFm resulted in an increased detection of Akkermansia genus, that showed an opposite pattern to that previously described in non‐transplanted HFD‐fed mice, which could be explained in terms of different microbiome initial conditions. Interestingly, Akkermansia spp.…”
Section: Discussionmentioning
confidence: 58%
“…Because MF is nondigestible, its effects are likely related to different factors at the gastrointestinal level. For example, supplementation with Tommy Atkins mango pulp was associated with improvement of gut microbiota, specifically, genus Bifidobacteria , Akkermansia , and Aldercrutzia , as well as modulation of short chain fatty acid production and gut inflammation (Ojo et al, ). Thus, MF consumption may be an interesting strategy to treat NAFLD, which is based on promoting beneficial microorganisms, whereas inhibiting pathogenic or harmful ones, resulting in a strengthened gut‐liver axis (Kirpich, Parajuli, & McClain, ).…”
Section: Discussionmentioning
confidence: 99%
“…Previous evidence has shown that IFN-γ-mediated adaptive immunity contributes to the progression of NASH and atherosclerosis (Sutti et al, 2014). Because MF is nondigestible, its effects are likely related to Akkermansia, and Aldercrutzia, as well as modulation of short chain fatty acid production and gut inflammation (Ojo et al, 2016). Thus, MF consumption may be an interesting strategy to treat NAFLD, which is based on promoting beneficial microorganisms, whereas inhibiting pathogenic or harmful ones, resulting in a strengthened gut-liver axis (Kirpich, Parajuli, & McClain, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…Altered gut microbiota composition has been linked to the development of hyperlipidemia and cardiometabolic diseases (Chan et al, 2016). A healthy intestinal environment comprises host and microbial factors, and relies on a functionally intact intestinal barrier and stable microbiota composition (Lu et al, 2016; Monk et al, 2019; Ojo et al, 2016). However, studies suggest that high‐fat diets (HFDs) may cause gut microbiota dysbiosis and intestinal integrity destruction.…”
Section: Introductionmentioning
confidence: 99%