Mangosteen Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study

Watanabe, Mikiko; Gangitano, Elena; Francomano, Davide; Addessi, Eliana; Toscano, Raffaella; Costantini, Danny L.; Tuccinardi, Dario; Mariani, Stefania; Basciani, Sabrina; Spera, Giovanni; Gnessi, Lucio; Lubrano, Carla

doi:10.20944/preprints201804.0049.v1

Cited by 14 publications

(2 citation statements)

References 19 publications

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“…Moreover, reports by Yamaguchi et al, (2000), Shetty and Pushpa (2018) and Deore et al, (2018) revealed that the fruit extract of G. indica significantly lowered the fasting blood glucose concentration in hyperglycemic rats in a long term study. Further, long term antihyperglycemic effects were reported based on Garcinia species such as G. cambogia, G. mangostana in diabetic animal models (Watanabe et al, 2018). Even though the present study was did not ilucidate the exact antidiabetic mechanisms of fruits of G. quaesita, we propose that the fruits of G. quaesita would lead to potent antidiabetic activity in a long term study most probably through an insulin-like activity same as other species of the genus Garcinia.…”

Section: Resultscontrasting

confidence: 57%

Antihyperglycemic activity of fruit extracts of Sri Lankan endemic species <i>Garcinia quaesita</i> Pierre “Rathgoraka” and its isolated compound, garcinol

et al. 2020

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The dried fruit of Garcinia quaesita Pierre (Clusiaceae), is a well-known endemic spice in Sri Lanka and has been documented in traditional medicine as an antidiabetic agent. The antihyperglycemic effect of cold water, hot water, water : acetone fruit extracts of G. quaesita and its isolated compound, garcinol in streptozotocin-induced diabetic rats was studied. The percentage improvements of glucose tolerance upon total area under the oral glucose tolerance curve in cold water, hot water and water:acetone extracts of G. quaesita (1.0 g/kg) were 6.2 %, 7.4 % and 8.1 %, respectively. The isolated compound, garcinol at the three selected doses (10 mg/kg, 20 mg/kg, 30 mg/kg), showed a dose dependent, antihyperglycemic activity of 23.6 %, 26.5 %, 31.1 % respectively compared to glibenclamide (0.5 mg/kg) (36.1 %) (p<0.05). The selected extracts of G. quaesita exhibited significant antihyperglycemic activity in streptozotocin-induced diabetic rats. The isolated compound, garcinol has significantly higher antihyperglycemic activity than the respective crude extracts. Accordingly, endemic dried fruits of G. quaesita and its isolated compound garcinol are promising antihyperglycemic agents and /or drug leads that would be beneficial in the management of diabetes mellitus.

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Section: Resultscontrasting

confidence: 57%

Antihyperglycemic activity of fruit extracts of Sri Lankan endemic species <i>Garcinia quaesita</i> Pierre “Rathgoraka” and its isolated compound, garcinol

et al. 2020

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“…This is because mangosteen rind is known to contain various chemical compounds that are beneficial for health, such as antioxidants, antimicrobial, anticancer, and anti-inflammatory agents (Ansori et al, 2020;Mahmudah et al, 2020). Mangosteen rind is also beneficial for weight loss (Kudiganti et al, 2016;Watanabe et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Enhancing the Knowledge and Skill of PKK and Karang Taruna Cadres in The Innovation of Mangosteen Fruit Products

Suciati,

Ekasari,

Miatmoko

et al. 2023

JPM

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Purpose: The current community service activities aim to provide knowledge and skills related to mangosteen and its processed products to the Songgon Village community Method: Transfer of knowledge and skill by lecturing and practice. Pre and post-tests were carried out to evaluate the participants’ knowledge before and after the workshop. Practical Applications: The knowledge and skill gained by PKK and Karang Taruna cadres in this workshop can be implemented in daily life. The participants learned how to make innovative products from mangosteen fruit so that it can be produced commercially. Thus, in the long term is expected to increase the income of Songgon Village Community. Conclusion: The results showed the participants' enthusiasm to participate in this activity, and the pre and post-tests demonstrated increased knowledge and skills. The next step requires intensive support for the Songgon Village community so that their products can be distributed commercially and provide economic benefits.

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Biological Properties in Relation to the Health-Promoting Effects of Independent and Combined Garcinia mangostana Pericarp and Curcuma in Lean Wistar Albino Rats

et al. 2023

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With the increase in verifications and proofs highlighting the association between diet and health, several food products, such as phenolic rich fruits and vegetables, have emerged as possessing potential health benefits. Plants rich with fiber and phenolic content have long been considered as a health-promoting dietary intervention. Therefore, the present work aimed to test the independent and combined potential benefits of mangosteen pericarp extract (MPE) and curcuma rhizome extract (CRE) consumption through an in vivo study on Wister albino rats. The data demonstrated that the three nutritional interventions had no effect on serotonin or glutamate, but dopamine was considerably increased in response to the combined effects of MPE and curcuma (p ˂ 0.025). The anti-inflammatory potency of independent MPE and curcuma, as well as their combined effects, recorded lower levels of IL12 in all groups compared to controls (p ˂ 0.05), and only a considerably lower IL-6 in combination treatment only (p ˂ 0.028). The three dietary interventions dramatically lowered leptin levels, with the combined treatment significantly lower than the healthy control group (p ˂ 0.001). The combined treatment significantly improved levels of malondialdehyde (MDA) and GSH as indicators of oxidative stress and antioxidant capability. Our data reported anti-dyslipidemic and anti-hyperglycemic effects of the three studied nutritional interventions, with the independent curcuma being the most effective anti-hyperglycemic compound (p ˂ 0.009). Collectively, the three used nutritional intervention strategies demonstrated promising health-promoting effects with no side effects.

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Mangosteen Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study

Cited by 14 publications

References 19 publications

Antihyperglycemic activity of fruit extracts of Sri Lankan endemic species <i>Garcinia quaesita</i> Pierre “Rathgoraka” and its isolated compound, garcinol

Antihyperglycemic activity of fruit extracts of Sri Lankan endemic species <i>Garcinia quaesita</i> Pierre “Rathgoraka” and its isolated compound, garcinol

Enhancing the Knowledge and Skill of PKK and Karang Taruna Cadres in The Innovation of Mangosteen Fruit Products

Biological Properties in Relation to the Health-Promoting Effects of Independent and Combined Garcinia mangostana Pericarp and Curcuma in Lean Wistar Albino Rats

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