Mania associated with codeine and paracetamol

Orr, Kenneth G.; Mostert, Johann; Castle, David

doi:10.1046/j.1440-1614.1998.00441.x

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Case reports and small clinical studies have suggested that opioid use can induce manic episodes in subjects with pre-existing affective disorders (Shaffer et al, 2007; Watts & Grady, 1997; Gonzalez-Pinto et al, 2001; Orr et al, 1998). While we do not have information on reasons for opioid use among individuals with bipolar disorder (e.g., to self-medicate back pain symptoms-analgesia or simply to “get high”-euphoria), we did find strong and significant associations for an increased risk of opioid use and dependence in the presence of bipolar disorder.…”

Section: Discussionmentioning

confidence: 99%

Pathways between nonmedical opioid use/dependence and psychiatric disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions

Martins

Keyes

Storr

et al. 2009

Drug and Alcohol Dependence

163

113

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Background-While nonmedical use of opioids and psychiatric disorders are prevalent in the population, little is known about the temporal ordering between nonmedical opioid use and dependence and psychiatric disorders.Method-Data were gathered in a face-to-face survey of the United States conducted in the 2001-2002 (NESARC wave 1). Participants were household and group quarters residents aged 18 years and older (n=43,093). Cox proportional hazards models with time-dependent covariates were used to investigate potential pathways between lifetime nonmedical opioid use/dependence and psychiatric disorders.Results-Preexisting psychiatric disorders (mood disorders, major depressive disorder, bipolar I disorder, anxiety disorders, panic and generalized anxiety disorders) were associated with an increased risk of nonmedical opioid use, with hazard ratios ranging from 2.2[95% CI=1.6-3.1] (any anxiety disorder) to 3.1[95% CI= 2.4-2.4] (bipolar I disorder). Preexisting nonmedical opioid use was associated with an increased risk of onset of psychiatric disorders, with hazard ratios ranging from 2.8[95% CI=:2.2-3.6] (generalized anxiety disorder) to 3.6[95% CI=2.6-4.9] (bipolar I disorder), adjusted for demographics and other illegal drug use. Nonmedical use of opioids led to the development of dependence more often among individuals with preexisting psychiatric disorders, † Corresponding author: Silvia S. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptDrug Alcohol Depend. Author manuscript; available in PMC 2010 July 1. Published in final edited form as:Drug Alcohol Depend. Conclusions-Our findings support a general vulnerability to nonmedical opioid use and major psychopathologies, as well as evidence for a 'self-medication' model for dependence resulting from nonmedical opioid use with bipolar disorder and generalized anxiety disorder.

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Section: Discussionmentioning

confidence: 99%

Pathways between nonmedical opioid use/dependence and psychiatric disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions

Martins

Keyes

Storr

et al. 2009

Drug and Alcohol Dependence

163

113

View full text Add to dashboard Cite

show abstract

“…Morphine, for example, decreases REM sleep and SWS, and increases awakenings or arousals (Table 3) [60]. If an opioid is chosen, it is important to observe such patients carefully, because opioids may produce excitation or even mania [65].…”

Section: Treatment Strategies For the Comorbidities Of Chronic Painmentioning

confidence: 99%

Comorbidities in Chronic Neuropathic Pain

2004

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Neuropathic pain arises from a lesion or dysfunction within the nervous system; the specific mechanisms that elicit neuropathic pain symptoms are the subject of ongoing research. It is generally acknowledged that neuropathic pain is extremely difficult to treat, and a major factor impacting outcomes is the presence of comorbidities such as poor sleep, depressed mood, and anxiety. Patients who suffer from chronic pain experience difficulties in initiating and maintaining sleep. Sleep deprivation has been associated with a decreased pain threshold, muscle aches, and stiffness in normal volunteers. The interrelationship of these factors is complex: Many chronic pain patients are depressed and anxious; sleep deprivation can lead to anxiety; and depression can be both the cause and the result of sleep disturbances. Thus, physicians must evaluate all aspects of pain, sleep, and mood in chronic pain patients. Several instruments have been developed to aid physicians in gathering qualitative and quantitative information from chronic pain patients. This triad of chronic pain, sleep disturbances, and depression/anxiety must be fully addressed if the patient is to be restored to optimal functionality. A multidisciplinary team approach allows for treatment of the whole patient. Nonpharmacologic interventions include relaxation therapy, sleep restriction therapy, and cognitive therapy. Strategies for pharmacologic interventions should attempt to maximize outcomes by employing, where possible, agents that address both the pain and the comorbidities. In this way, functionality may be restored and the patient's quality of life improved.

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The Role of Peer Bystanders in School Bullying: Positive Steps Toward Promoting Peaceful Schools

Lodge¹,

Frydenberg²

2005

Theory Into Practice

101

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Mania associated with codeine and paracetamol

Abstract: Mania can be induced by large doses of Panadeine forte, particularly if there is a biological predisposition.

Cited by 3 publications

References 11 publications

Pathways between nonmedical opioid use/dependence and psychiatric disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions

Pathways between nonmedical opioid use/dependence and psychiatric disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions

Comorbidities in Chronic Neuropathic Pain

The Role of Peer Bystanders in School Bullying: Positive Steps Toward Promoting Peaceful Schools

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