Mania/hypomania associated with withdrawal of antidepressants

Guduk, Mehmet; Erensoy, Ilke Yeser; Ersumer, Filiz

doi:10.5350/dajpn2013260311

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…This effect involves cytokine signaling pathways 31 and can be induced by a wide range of agents, including polysaccharide (LPS) [83][84][85][86][87][88][89] , viral mimetic polyriboinosinic-polyribocytidylic acid (Poly I:C) 90 , interferon (IFN)-α [91][92][93] and bacillus Calmette-Guerin (BCG) [94][95] . Some overlaps between drug withdrawal and depression also exist 96 and have been reported in rodents for cocaine, amphetamine, ethanol, morphine and nicotine [54][55][56] (also note hypomania following antidepressant discontinuation both in clinical practice and animal models [97][98] ).…”

Section: Introductionmentioning

confidence: 93%

Animal models of major depressive disorder and the implications for drug discovery and development

Demin

Sysoev

Chernysh

et al. 2019

Expert Opinion on Drug Discovery

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Depression is a highly debilitating syndrome that affects the global population and is associated with disabilities and suicide. Depression remains poorly studied and is often treatment resistant and recurrent. Thus, development of new therapies and drugs is needed in the field. Animal models are indispensable for translational biological psychiatry, and may advance the study of depression. While poor understating of psychiatric disorders (including depression) is slowing down further progress in the field, novel approaches continuously emerge that may help untangle disorder heterogeneity and blurred categories of contemporary diseases classification systems. Dividing core symptoms into easily translatable phenotypes is an effective way to reevaluate current paradigms. Also, other, more deep and complicated approaches and theories based on the endophenotype paradigm, such as 'cross-species trait genetic' and 'domain interplay concept' do continuously emerge to improve current paradigms and drug screening.

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Section: Introductionmentioning

confidence: 93%

Animal models of major depressive disorder and the implications for drug discovery and development

Demin

Sysoev

Chernysh

et al. 2019

Expert Opinion on Drug Discovery

View full text Add to dashboard Cite

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Paroxetine/sertraline

2021

Reactions Weekly

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Olası Paroksetin Tedavisinin Kesilmesi İle İlişkili İlk Atak Mani

Çam¹

2015

Cukurova Medical Journal

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Antidepressant-induced mania has been reported with all major antidepressant classes in a subgroup of about 20-40% of bipolar patients. Mania/hypomania due to antidepressant withdrawal is rarely reported in the literature as case report. Mania/hypomania due to antidepressant withdrawal is reported to be associated with tricyclic antidepressants as well as selective serotonin reuptake inhibitors. This article offered mania occurring after discontinuation of treatment with paroxetine male patient. Mania associated with antidepressant discontinuation of the differential diagnosis, possible mechanisms, and the treatment has been discussed in the literature. Clinicians should be cautious mania/hypomania associated with antidepressant withdrawal. To do follow-up studies and case reports will help to clarify this table. Key words: Antidepressant discontinuation, hypomania, mania, paroxetine ÖZET Antidepresan ilaç kullanan duygudurum bozukluğu olan hastalarda hipomanik/manik kayma riskinin %20-40 arasında olduğu bildirilmektedir. Antidepresan ilaçların azaltılması yada kesilmesi ile ortaya çıkan hipomani/mani ise olgu sunumlarıyla sınırlıdır. Daha çok trisiklik antidepresanların kesilmesi ile ortaya çıkmakla beraber seçici serotonin geri alım inhibitörlerinin kesilmesi ile de bildirilmiştir. Bu yazıda paroksetin tedavisinin kesilmesini takiben mani tablosu ortaya çıkan erkek hasta sunulmuş, antidepresan kesilmesi ile ortaya çıkan maninin ayırıcı tanısı, olası mekanizmaları, tedavisi literatür ışığında tartışılmıştır. Klinisyenler antidepresan kesimi ile ilişkili mani/hipomani açısından dikkatli olmalıdır. Bu alanda yapılacak izlem çalışmaları ve olgu bildirimleri bu tablonun aydınlatılmasına yardımcı olacaktır. Anahtar kelimeler: Antidepresan kesilmesi, mani, hipomani, paroksetin.

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Mania/hypomania associated with withdrawal of antidepressants

Cited by 3 publications

References 11 publications

Animal models of major depressive disorder and the implications for drug discovery and development

Animal models of major depressive disorder and the implications for drug discovery and development

Paroxetine/sertraline

Olası Paroksetin Tedavisinin Kesilmesi İle İlişkili İlk Atak Mani

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