Manifestaciones oculares y sistémicas del síndrome de Möebius

Pertierra, Africa; González, Pedro; Canto, Vanessa Bosch; Favila, Juan Carlos Ordaz; Echenique, Juan Carlos Juárez

doi:10.1016/j.anpedi.2013.10.023

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…Although it has been reported for several decades that MS does not have a clear gender predilection, based on a detailed evaluation of previous studies, we found a slight tendency for affected individuals to be male. The proportion of cases of masculine sex was reported in Brazil by Pastuszak et al in 1998 as 56% (n = 96) and by Gonzales et al in the same year as 63% (n = 19); in Switzerland by Strömland et al in 2002 as 72% (n = 25); in the Netherlands by Verzijil in 2003 as 54% (n = 37); and in Spain by Fons‐Estupiña in 2007 as 80% (n = 20) and by Pertierra et al in 2014 as 62.5% (n = 64) . Welschen, in Argentina, is the only study to find the opposite trend, reporting the proportion of cases of male sex as 41% (n = 26) .…”

Section: Discussionmentioning

confidence: 89%

Moebius syndrome: Craniofacial clinical manifestations and their association with prenatal exposure to misoprostol

Ruge‐Peña

Valencia

Cabrera

et al. 2020

Laryngoscope Investig Oto

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Background A growing link between prenatal exposure to misoprostol (PEM) and Moebius syndrome (MS) or sequence has been reported. Our objectives were to describe the craniofacial clinical manifestations associated with MS and to determine the frequency of PEM, comparing cases of exposure and nonexposure. Methods A descriptive, cross‐sectional study of 140 patients with MS. Clinical evaluations, as well as 140 interviews with mothers residing in 39 cities or districts of Colombia, were carried out between April 2008 and May 2018. Additionally, previous clinical history of each case was reviewed. Results The average age of the patients with MS was 8.4 years (29 days to 48 years). All of them presented facial nerve involvement and abducens, 112 (80.8%) with bilateral facial paralysis. 98.5% presented craniofacial disorders, and there were no significant differences between those exposed and not exposed to misoprostol. Forty‐seven percentage of patients (64 cases) presented PEM, in 98.4% of which abortion had been intended. Conclusion PEM could have an influence in the appearance of new cases of MS by increasing the frequency of bleeding during gestation, without increasing the number of associated craniofacial malformations. We present the biggest series on MS and craniofacial findings in the literature, along with a meaningful reference for its understanding. Level of Evidence 3b.

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Section: Discussionmentioning

confidence: 89%