Introduction: hematological disorders constitute one of the most interesting problems to be considered by the stomatologist in his daily practice. Objective: to characterize the comprehensive stomatological care in patients with hematological diseases at the Provincial Pediatric Teaching Hospital "Pepe Portilla" in the period from September 2020 to September 2021. Methods: An observational, descriptive, cross-sectional study was developed with the purpose of characterizing the comprehensive stomatological care in patients with hematological diseases at the "Pepe Portilla" Pediatric Provincial Teaching Hospital, from September 2020 to September 2021. The universe and the sample consisted of 21 patients, the sample was selected intentionally, according to the inclusion and exclusion criteria. The data were obtained from the clinical history of the patients. Descriptive and inferential statistical methods were used to describe the variables. Results: patients aged between 7 and 12 years had a greater presence with 52,38 %. There was a greater presence of white patients with 42,86 %, with a greater predominance of the female sex. Conservative treatment was the most needed in 52,34 % of these patients. The use of pharmacological prophylaxis in 47,62 % of the cases, of which 28,57 % were destined to surgical type treatment. Conclusions: Most of the patients examined presented poor oral hygiene. Pharmacological prophylaxis was the most used method prior to stomatological treatment. Supportive physiotherapy, analgesia and antimicrobial therapy were part of the treatment for all postsurgical complications.