Manifestações musculoesqueléticas associadas à hepatite C crônica

Nakamura, Andréa Aparecida Siqueira

doi:10.11606/d.5.2013.tde-25112013-102520

Cited by 1 publication

(1 citation statement)

References 84 publications

(174 reference statements)

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“…Unfortunately, SPR analysis showed the aptamers to have very low affinity to MC-LR. (143) In vitro selection of ssDNA aptamers for MC-LR, LA, and YR with low dissociation constants have been developed by Ng et al (144) However, three sequences had high affinity and selectivity to LR, LA, and YR. Aptamers with relatively low affinity may exhibit high electrochemical signals depending on the different molecular conformations during binding of the analyte target. (144) An innovative aptamer systematic evolution of ligand by exponential enrichment (SELEX) approach for MC-RR involves graphene oxide (GO).…”

Section: Aptamersmentioning

confidence: 99%

A Comprehensive Review: Development of Electrochemical Biosensors for Detection of Cyanotoxins in Freshwater

et al. 2019

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Cyanobacteria harmful algal blooms are increasing in frequency and cyanotoxins have become an environmental and public concern in the U.S. and worldwide. In this Review, the majority of reported studies and developments of electrochemical affinity biosensors for cyanotoxins are critically reviewed and discussed. Essential background information about cyanobacterial toxins and electrochemical biosensors is combined with the rapidly moving development of electrochemical biosensors for these toxins. Current issues and future challenges for the development of useful electrochemical biosensors for cyanotoxin detection that meet the demands for applications in field freshwater samples are discussed. The major aspects of the entire review article in a prescribed sequence include (i) the state-of-the-art knowledge of the toxicity of cyanotoxins, (ii) important harmful algal bloom events, (iii) advisories, guidelines, and regulations, (iv) conventional analytical methods for determination of cyanotoxins, (v) electrochemical transduction, (vi) recognition receptors, (vii) reported electrochemical biosensors for cyanotoxins, (viii) summary of analytical performance, and (ix) recent advances and future trends. Discussion includes electrochemical techniques and devices, biomolecules with high affinity, numerous array designs, various detection approaches, and research strategies in tailoring the properties of the transducer-biomolecule interface. Scientific and engineering aspects are presented in depth. This review aims to serve as a valuable source to scientists and engineers entering the interdisciplinary field of electrochemical biosensors for detection of cyanotoxins in freshwaters.

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Section: Aptamersmentioning

confidence: 99%