Manifestation der eosinophilen Granulomatose mit Polyangiitis im Kopf-Hals-Bereich im zeitlichen Verlauf unter Berücksichtigung der systemischen Krankheitsaktivität

Andersen, Henrik Arlif; Götz, Paul; Bremer, Jan Phillip; Laudien, Martin

doi:10.1007/s00393-018-0439-0

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…EGPA is a rare subgroup of eosinophilic airway inflammation, even within the severe asthmatic group. The diagnosis of EGPA should be considered in patients with asthma, chronic rhinosinusitis, and eosinophilia who experience clinical deterioration of the general condition and further complications of the nervous system, skin, lungs, or heart as well as kidneys [ 33 , 34 ]. The vast majority (> 90%) of patients diagnosed with EGPA suffer from previously “long-standing” asthma, rarely showing seasonal exacerbations and worsening over time.…”

Section: Discussionmentioning

confidence: 99%

EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP)

Hagemann,

Laudien,

Becker

et al. 2024

ALS

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Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) was formerly known as Churg-Strauss syndrome. The condition is characterized by disseminated necrotizing vasculitis with extravascular granulomas associated with hypereosinophilia. The vasculitides affect small vessels and are associated with antineutrophil cytoplasmic antibodies (ANCAs) detectable in the blood. Distinguishing between type 2-mediated chronic airway inflammation such as chronic rhinosinusitis with nasal polyps (CRSwNP) without vasculitis can be clinically challenging and should be considered. Materials and methods: Immunological background, diagnosis, and therapy of EGPA were identified through literature searches in Medline, PubMed, as well as national and international studies (ClinicalTrials.gov) and the Cochrane Library. Human studies published up to and including 10/2023 on the topic were considered. Results: In cases of deteriorating general health with previously known eosinophilic inflammation of the upper and lower airways, EGPA and its interdisciplinary investigation should be considered. Various types of eosinophilic inflammation and syndromes must be considered differentially. Conclusion: Characterization of mucosal airway inflammation through biomarker determination is meaningful and occasionally makes the difference for targeted therapy.

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Section: Discussionmentioning

confidence: 99%

EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP)

Hagemann,

Laudien,

Becker

et al. 2024

ALS

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Vasculitis and the ear: a literature review

Rahne¹,

Plontke²,

Keyßer

2020

Current Opinion in Rheumatology

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Purpose of review Systemic vasculitides as a group of inflammatory disorders of blood vessels may show clinical manifestations in the ear. This article reviews the recent literature about vasculitis of the ear or the cochleovestibular system, focusing on giant-cell arteritis, Takayasu's arteritis, polyarteritis nodosa, Kawasaki disease, microscopic polyangiitis, granulomatosis with polyangiitis (GPA), eosinophilic GPA, systemic lupus erythematosus, Cogan's syndrome and Behçet's disease. Recent findings In patients with vasculitis, hearing impairment is a frequent problem, followed by tinnitus and vertigo. The severity of sensorineural hearing loss can range from mild impairment to deafness. Autoimmune diseases can induce a conductive hearing loss as a result of effusions of the middle ear, the inflammation of the mucosa of the Eustachian tube, or the involvement of the ossicular chain. Vertigo may be caused by the temporary or permanent occlusion of the labyrinthine or the anterior vestibular artery. Middle ear inflammation is frequent in GPA and eosinophilic GPA. Summary The progressive sensorineural hearing loss in polyarteritis nodosa or Cogan's syndrome patients may be treated by cochlear implantation.

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Manifestation der eosinophilen Granulomatose mit Polyangiitis im Kopf-Hals-Bereich im zeitlichen Verlauf unter Berücksichtigung der systemischen Krankheitsaktivität

Cited by 2 publications

References 27 publications

EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP)

EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP)

Vasculitis and the ear: a literature review

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