Manifestation of multiple sclerosis with paranoidhallucinatory psychosis

Reimer, Jens; Aderhold, Volkmar; Lambert, Martin

doi:10.1007/s00415-005-0024-8

Cited by 16 publications

(7 citation statements)

References 13 publications

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“…However, caution is required in relation to the choice of psychotropic agent prescribed due to the potential for exacerbating adverse effects, especially extra-pyramidal side effects (EPSE). Consequently, the use of low-dose atypical (second-generation) antipsychotic agents, given their lower propensity for EPSE for the control or alleviation of psychosis, is suggested with trials indicating clinical benefit from a variety of psychotropic agents including risperidone,91 ziprasidone,92 clozapine,93 aripiprazole,94 quetiapine61 and olanzapine,61 although clozapine is predominantly prescribed for treatment-resistant psychosis due to its association with agranulocytosis 61. An additional rationale for treatment with risperidone and quetiapine relates to their demonstrated disease-modifying characteristics in EAE mice models 95 96.…”

Section: Psychosismentioning

confidence: 99%

Neuropsychiatric syndromes of multiple sclerosis

Murphy

O’Donoghue

Counihan

et al. 2017

J Neurol Neurosurg Psychiatry

144

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Neuropsychiatric signs and symptoms occur frequently in individuals with multiple sclerosis (MS), either as the initial presenting complaint prior to a definitive neurological diagnosis or more commonly with disease progression. However, the pathogenesis of these comorbid conditions remains unclear and it remains difficult to accurately elucidate if neuropsychiatric symptoms or conditions are indicators of MS illness severity. Furthermore, both the disease process and the treatments of MS can adversely impact an individual's mental health. In this review, we discuss the common neuropsychiatric syndromes that occur in MS and describe the clinical symptoms, aetiology, neuroimaging findings and management strategies for these conditions.

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Section: Psychosismentioning

confidence: 99%

Neuropsychiatric syndromes of multiple sclerosis

Murphy

O’Donoghue

Counihan

et al. 2017

J Neurol Neurosurg Psychiatry

144

View full text Add to dashboard Cite

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“…Myelinated axons with similar destinations bundle together into fiber tracts, and it is these fiber tracts that constitute the infrastructure for long-distance communication between spatially disparate GM regions. In light of the fact that fiber tract damage can disrupt or even disable communication between connected brain regions [8], and given that psychotic symptoms are unusually common in patients with WM diseases (such as metachromatic leukodystrophy [9] and multiple sclerosis [10]), a number of researchers have speculated as to the existence and implications of WM abnormalities in patients with schizophrenia, [2, 11–14]. The results of genetic analyses that have revealed the abnormal expression of several myelination-related genes in patients with schizophrenia [15] have also contributed to an increased interest into the role of WM abnormalities in the disorder.…”

Section: Introductionmentioning

confidence: 99%

Diffusion Tensor Imaging, Structural Connectivity, and Schizophrenia

Whitford

Kubicki

Shenton

2011

Schizophrenia Research and Treatment

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A fundamental tenet of the “disconnectivity” theories of schizophrenia is that the disorder is ultimately caused by abnormal communication between spatially disparate brain structures. Given that the white matter fasciculi represent the primary infrastructure for long distance communication in the brain, abnormalities in these fiber bundles have been implicated in the etiology of schizophrenia. Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that enables the visualization of white matter macrostructure in vivo, and which has provided unprecedented insight into the existence and nature of white matter abnormalities in schizophrenia. The paper begins with an overview of DTI and more commonly used diffusion metrics and moves on to a brief review of the schizophrenia literature. The functional implications of white matter abnormalities are considered, particularly with respect to myelin's role in modulating the transmission velocity of neural discharges. The paper concludes with a speculative hypothesis about the relationship between gray and white matter abnormalities associated with schizophrenia.

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“…There are several case reports describing psychosis either as an initial presentation or symptom of MS relapse [3][4][5]. The main question arising from these case reports is: is there a single lesion that can cause psychosis in MS patients?…”

Section: Discussionmentioning

confidence: 96%

Psychotic reaction as a manifestation of multiple sclerosis relapse treated with plasma exchange

et al. 2011

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We present a patient with a clinically isolated syndrome suggestive of multiple sclerosis, who developed a full-blown picture of paranoid psychosis with suicidal attempt. Four new lesions were observed on brain MRI, one in the left and one in the right temporal lobe, one subcortically in the cingulate gyrus and one centrally in the tegmentum of the midbrain. The patient was treated with plasma exchange and recovered completely. Psychosis is not so rare symptom of multiple sclerosis as previously reported, and poses a major treatment challenge. A combination of lesions at strategic locations was a presumed mechanism of psychosis in this patient.

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Manifestation of multiple sclerosis with paranoidhallucinatory psychosis

Cited by 16 publications

References 13 publications

Neuropsychiatric syndromes of multiple sclerosis

Neuropsychiatric syndromes of multiple sclerosis

Diffusion Tensor Imaging, Structural Connectivity, and Schizophrenia

Psychotic reaction as a manifestation of multiple sclerosis relapse treated with plasma exchange

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