Manifestations d’hypersensibilité aux antituberculeux

Pyrazinamide-Induced Anaphylaxis: Diagnosed by Skin Test and Successful Desensitization

“…Cutaneous manifestations are the most frequent hypersensitivity reactions to these drugs, and PZA has been implicated in most such cases [7]. Anaphylaxis is also a potential hypersensitivity reaction to this commonly prescribed antituberculosis drug, but it has not been clearly reported before.There is only one report suggesting an anaphylactic-type reaction developed after the initiation of antituberculosis therapy with PZA [8].…”

Rifampicin induced shock during re-exposure for treatment of latent tuberculosis

“…Within the literature, there a number of case reports of rifampicin induced shock 11–17. A review of reported cases from 1966 to 1999 by Martinez et al found that most presented with prodromes (usually rash) prior to the reaction, and that 75% experienced the reaction within minutes of exposure 8.…”

“…A review of reported cases from 1966 to 1999 by Martinez et al found that most presented with prodromes (usually rash) prior to the reaction, and that 75% experienced the reaction within minutes of exposure 8. Symptoms included severe hypotension with fever, exanthema, dyspnoea, abdominal pain and vomiting, with variable organ involvement 8 11–17…”

L’intérêt de l’accoutumance aux antituberculeux majeurs

“…Même si les effets secondaires de ce traitement sont multiples, les réactions d'hypersensibilité allergique sont assez rares (5% des cas), elle sont plus fréquentes chez les terrains immunodéprimés par le VIH (25% des cas), les insuffisants hépatiques et rénaux, et en cas d'un traitement administré d'une façon intermittente [ 1 , 2 ]. Ormerod et al ont montré dans leur étude que ces réactions sont plus fréquentes chez les femmes que chez les hommes [ 2 – 4 ]. Tous les antituberculeux peuvent être incriminés, avec par ordre de fréquence le PZA, la streptomycine (STP), l'ETB, la RIF, et l'INH [ 5 ].…”