Manifestations of copper excess

Bremner, I.

doi:10.1093/ajcn/67.5.1069s

Cited by 322 publications

(214 citation statements)

References 31 publications

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“…Copper can also directly bind to protein sulfhydryl and amino groups, leading to structural and functional modifications (13,30,38,41,68). Finally, copper can bind to DNA to form adducts and is involved in chromatin condensation (11,58). Thus, it is critical for organisms to maintain homeostatic concentrations of copper, because abnormally high or low levels can lead to pathological conditions (8).…”

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confidence: 99%

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Song

Freedman

2009

Physiological Genomics

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Copper is an essential trace element; however, at supraphysiological levels, it can be extremely toxic. Microarray data from HepG2 cells exposed to 100, 200, 400, and 600 μM copper for 4, 8, 12 and 24 h were generated and analyzed. Principal components, K-means, and hierarchical clustering, interactome, and pathway mapping analyses indicated that these exposure conditions induce physiological and toxicological changes in the HepG2 transcriptome. As a general trend, when the level of toxicity increases, the number and diversity of affected genes, Gene Ontology categories, regulatory pathways, and complexity of interactomes increase. Physiological responses to copper include transition metal ion binding and responses to stress/stimulus, whereas toxicological responses include apoptosis, morphogenesis, and negative regulation of biomolecule metabolism. The global gene expression profile was overlaid onto biomolecular interaction networks and signal transduction cascades using pathway mapping and interactome identification. This analysis indicated that copper modulates signal transduction pathways associated with MAPK, NF-κB, death receptor, IGF-I, hypoxia, IL-10, IL-2, IL-6, EGF, Toll-like receptor, protein ubiquitination, xenobiotic metabolism, leukocyte extravasation, complement and coagulation, and sonic hedgehog signaling. These results provide insights into the global and molecular mechanisms regulating the physiological and toxicological responses to metal exposure.

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confidence: 99%

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Song

Freedman

2009

Physiological Genomics

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“…Excessive intracellular accumulation of Cu promotes formation of reactive oxygen species (ROS), catalyzing the reaction between the superoxide anion and hydrogen peroxide and production of hydroxyl radical. Furthermore, Cu can bind directly to free thiols of cysteines (Cys), leading to oxidation and crosslinks between proteins, thus inactivating enzymes or impairing structural proteins (13). Cu induced ROS generation initiate apoptotic/necrotic processes or other pathologies like cancer, neurological diseases, and aging (14).…”

Section: Discussionmentioning

confidence: 99%

Hematological and hepatic alterations among copper mine workers and office employees in a copper mine in the west of Iran, 2015

Lotfi

Rezazadeh

Ebrahimpour

2018

JOHE

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Article InfoBackground: Workers in different occupational positions experience significant Cu exposures, however, Cu toxicity has not been fully studied as compared to other heavy metals. In the present study, hematological and hepatic alterations have been investigated among copper mine workers. Materials and Methods: This descriptive study was conducted in a copper mine in west of Iran, on 402 copper mine workers (study group) and 52 office employees (control group) during winter 2015. 5ml blood samples were provided from each subject and hematological and hepatic parameters including white blood cell (WBC), platelet (PLT), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCH), lymphocytes, neutrophils, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum Cu levels have been determined using their commercial kits. The results were analyzed in the SPSS software using t-test and regression method. Results: ALT, AST, HGB, MCV, MCH and plasma Cu levels among the workers were significantly higher than the office employees (p<0.050). WBC and RBC counts among the workers were significantly lower than the control group (p= 0.049 and 0.024, respectively). Serum Cu levels of 215 of the workers were higher than its normal recommended range (120 µg/dl). For the subjects with serum Cu levels above 150 µg/dl, increases in AST and ALT were in compliance with serum Cu levels increase. Conclusions: Significant hepatic and hematological alteration were observed among copper miners compared to control group. Employment of workers with background hematological and hepatic disorders in copper industries must be accompanied with great caution.

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“…Copper is a heavy metal and copper toxicity is allied with stomach upset, queasiness, and diarrhea and can front tissue injury and disease (42). At high concentrations, copper is known to produce oxidative damage to biological systems, including peroxidation of lipids or other macromolecules (43,44). Copper, however, is an essential trace mineral for man, it plays an important role in diseases in which oxidant stress is elevated.…”

Section: Chemical Analysismentioning

confidence: 99%

Assessment of microbiological and chemical qualities of selected cocoa, tea and coffee brands in Nigerian markets

Anosike¹,

Oranusi²

2018

Af J Clin Exp Micro

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Background: Cocoa, Tea, and Coffee products are consumed worldwide; they are rich in nutrient and, thus, prone to microbial contaminations that could cause food infections and intoxication. Objective: the objectives of the paper are: To evaluate the microbial and chemical qualities of some popular brands of cocoa, coffee and tea products in Nigerian market and benchmark it with standard specifications, to determine the products safety for human consumption and proffer solutions on ways to prevent possible food borne hazards associated with these products. Materials and Methods: This study examined the microbiological and chemical qualities of some brands of these products at the consumer level using standard analytical methods. Results: Five (50%) of the cocoa products had coliform counts (cfu/g) significantly (p<0.05) higher than acceptable limits and range from 2.6×10 1 ±0.01 to 4.6×10 1 ±0.01. The mean total aerobic plate count and fungal counts (cfu/g) cocoa, coffee, and tea were not significantly (p<0.05) different from standard specifications. The microbial isolates include species of Bacillus (59.2%), Staphylococcus(12.0%), Enterobacter(1.6%), Aspergillus(20.0%), Penicillium(14.4%) and Saccharomyces (12.0%). Moisture contents higher than 6% and 3% standard specifications in tea and cocoa products was detected in 7(70%) of tea and 2(20%) of cocoa products respectively. The samples are rich in phenol contents (mg/ml) and contain varying concentrations of manganese, calcium, iron, and copper. Free Radical Scavenging (DPPH) activity of 6.2±0.01 to 16.3±0.02µg/ml was detected in the samples. Conclusion: Some cocoa products contain unacceptable levels of coliforms, the high moisture contents above 3 and 6% standard specifications in some cocoa and tea products could encourage the proliferation of mycotoxigenic moulds and pathogenic bacteria to hazardous levels. The use of good raw materials, compliance to good manufacturing practices (GMP) and apt storage are advocated. Keywords: Chemical qualities, Cocoa, Coffee, Microbial qualities, Mycotoxigenic moulds, Tea ÉVALUATION DES QUALITÉS MICROBIOLOGIQUES ET CHIMIQUES DE CACAO, THÉ ET CAFÉ RÉPUTÉES DANS LES MARCHÉS NIGÉRIANS

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Manifestations of copper excess

Cited by 322 publications

References 31 publications

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Hematological and hepatic alterations among copper mine workers and office employees in a copper mine in the west of Iran, 2015

Assessment of microbiological and chemical qualities of selected cocoa, tea and coffee brands in Nigerian markets

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