Manifestations of human atherosclerosis across vascular beds

Jovin, Daniel G.; Sumpio, Bauer E.; Greif, Daniel M.

doi:10.1016/j.jvsvi.2024.100089

Cited by 3 publications

(1 citation statement)

References 117 publications

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“…Atherosclerosis is a major cause of global mortality, responsible for nearly 10 million deaths each year. The plaques mainly develop in the coronary and carotid arteries, the aorta, and the peripheral arteries of the lower limbs [ 24 , 25 ]. The first reports on the coexistence of CAD and peripheral artery disease come from the 1980s [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Ten-Year Outcomes in Patients Undergoing Simultaneous Coronary and Renal Angiography—Does Renal Artery Stenosis Matter?

Kern,

Stompór,

Bojko

et al. 2024

JCM

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Background: We aimed to characterize the population of consecutive patients undergoing coronary angiography with simultaneous renal artery angiography and assess prognostic factors at a 10 year follow-up. Methods: The KORONEF study was a prospective, single-center, observational, and descriptive study with 492 patients included. We analyzed several baseline demographics, clinical and periprocedural characteristics, and laboratory data, and we assessed the results of coronary angiography and renal artery angiography. Results: The study population consisted of 37.2% women, and the mean age was 64.4 ± 9.9 years (min. 30 years, max. 89 years). Angiography revealed significant renal artery stenosis (RAS) in 35 (7.1%) patients. Among patients with significant RAS (≥50%), we observed more women (57.1% vs. 35.7%, p = 0.011), and patients were older (69.1 ± 10.4 years vs. 64.0 ± 9.7 years, p = 0.005). In the whole population, all-cause death was reported in 29.9% of patients, myocardial infarction (MI) rate—in 11.8%, and stroke—in 4.9%. In the multivariable analysis, independent predictors of death were age 65–75 years (HR 2.88), age > 75 years (HR 8.07), diabetes (HR 1.59), previous MI (HR 1.64), chronic kidney disease (HR 2.22), unstable angina (HR 0.37), and left ventricular ejection fraction > 60% (HR 0.43). Conclusions: Over a 10 year follow-up, the all-cause death rate was 29.9%, showing no statistically significant differences between patients with and without significant RAS.

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Section: Discussionmentioning

confidence: 99%

Ten-Year Outcomes in Patients Undergoing Simultaneous Coronary and Renal Angiography—Does Renal Artery Stenosis Matter?

Kern,

Stompór,

Bojko

et al. 2024

JCM

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Peripheral arterial atherosclerosis and heart failure: state of the art review

Genkel,

Latysheva,

Ershov

et al. 2024

jour

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Heart failure is considered as a terminal stage of the cardiovascular continuum, beginning with exposure to risk factors followed by the development of asymptomatic cardiovascular damage, progressing to clinically manifest disease. Conventional risk factors such as arterial hypertension, dyslipidemia, obesity, and diabetes mellitus, on the one hand, directly cause structural and functional changes in the heart, and on the other hand, contribute to the development and progression of atherosclerosis. Despite the fact that the multifocal nature of atherosclerosis is well known, research data on the role of peripheral arterial atherosclerosis in the development of heart failure are extremely limited. The study of potential relationships between atherosclerosis of peripheral arteries and heart failure is relevant in all sex and age groups of patients.

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Investigating the Interplay between Cardiovascular and Neurodegenerative Disease

Cousineau,

Dawe,

Alpaugh

2024

Biology

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Neurological diseases, including neurodegenerative diseases (NDDs), are the primary cause of disability worldwide and the second leading cause of death. The chronic nature of these conditions and the lack of disease-modifying therapies highlight the urgent need for developing effective therapies. To accomplish this, effective models of NDDs are required to increase our understanding of underlying pathophysiology and for evaluating treatment efficacy. Traditionally, models of NDDs have focused on the central nervous system (CNS). However, evidence points to a relationship between systemic factors and the development of NDDs. Cardiovascular disease and related risk factors have been shown to modify the cerebral vasculature and the risk of developing Alzheimer’s disease. These findings, combined with reports of changes to vascular density and blood–brain barrier integrity in other NDDs, such as Huntington’s disease and Parkinson’s disease, suggest that cardiovascular health may be predictive of brain function. To evaluate this, we explore evidence for disruptions to the circulatory system in murine models of NDDs, evidence of disruptions to the CNS in cardiovascular disease models and summarize models combining cardiovascular disruption with models of NDDs. In this study, we aim to increase our understanding of cardiovascular disease and neurodegeneration interactions across multiple disease states and evaluate the utility of combining model systems.

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Manifestations of human atherosclerosis across vascular beds

Cited by 3 publications

References 117 publications

Ten-Year Outcomes in Patients Undergoing Simultaneous Coronary and Renal Angiography—Does Renal Artery Stenosis Matter?

Ten-Year Outcomes in Patients Undergoing Simultaneous Coronary and Renal Angiography—Does Renal Artery Stenosis Matter?

Peripheral arterial atherosclerosis and heart failure: state of the art review

Investigating the Interplay between Cardiovascular and Neurodegenerative Disease

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