Manifold Roles of Ceramide Metabolism in Non-Alcoholic Fatty Liver Disease and Liver Cancer

Wang, Kai; Wei, Yiran; Xu, Ruijuan; Li, Yiyi; Mao, Cungui

doi:10.1007/978-981-19-0394-6_11

Cited by 3 publications

(1 citation statement)

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“…Several different CerS have been identified in both pathways, and modulation of these enzymes is reported in many mechanisms including apoptosis and protein kinase inhibition (262)(263)(264). Several studies showed that decreased levels of ceramides are reported in many malignancies and tumor progression, while ceramide levels are observed to be increased by chemotherapies (265)(266)(267)(268). Additionly, several tyrosine kinase inhibitors (TKI) increase production of CerS on a nuclear level, which in turn leads to upregulation of ceramide biosynthesis (269,270).…”

Section: Discussionmentioning

confidence: 99%

Ceramides and Ceramide Synthases in Cancer: Focus on Apoptosis and Autophagy

Alizadeh¹,

Rosa²,

Weng³

et al. 2023

Preprint

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Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides’ fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the development of new treatments to activate or inhibit a single type of ceramide synthase, thereby regulating the apoptosis induction or cross talk of apoptosis and autophagy in cancer cells. Moreover, the apoptotic function of ceramide suggests that ceramide analogues can pave the way for the development of novel cancer treatments. Therefore, in the current review paper we discuss the impact of ceramide synthases and ceramides in regulation of apoptosis and autophagy in context of different types of cancers. We also briefly introduce the latest methods to analyze the lipids in biological samples. Finally, we discuss the drug development strategies focusing on the ceramide synthases and ceramides as future therapeutic approaches in cancer therapy.

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