Manitoba Lingonberry (<i>Vaccinium vitis-idaea</i>) Bioactivities in Ischemia-Reperfusion Injury

Isaak, Cara K.; Petkau, Jay C.; Karmin, O; Debnath, Samir C.; Siow, Yaw L.

doi:10.1021/acs.jafc.5b00797

Cited by 35 publications

(34 citation statements)

References 44 publications

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“…This effect was induced through the generation of ROS and was attributed to activation of caspase 3 and down-regulation of UHRF1 and Bcl-2. In one study, other researchers have proven the inhibitory effect of lingonberry methanolic extract and of its anthocyanin-rich and phenolic-rich fractions against apoptosis induced by ischemia-reperfusion [75].…”

Section: Anti-cancer Activitymentioning

confidence: 99%

Phenolic Antioxidants in Aerial Parts of Wild Vaccinium Species: Towards Pharmaceutical and Biological Properties

2019

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Phenolic compounds are a widespread group of secondary metabolites found in all plants, representing the most desirable antioxidants due to their potential to be used as additives in the food industry (inhibition of lipid oxidation), and in cosmetology and medicine (protection against oxidative stress). In recent years, demand for the identification of edible sources rich in phenolic antioxidants, as well as the development of new natural plant products to be used as dietary supplements or pharmaceuticals, has been a great preoccupation. At present, from the “circular economy” perspective, there is an increased interest to use agricultural waste resources to produce high-value compounds. Vaccinium leaves and stems are considered essentially an agro-waste of the berry industry. Scientific studies have shown that phenolic compounds were found in a markedly higher content in the leaves and stems of Vaccinium plants than in the fruits, in agreement with the strongest biological and antioxidant activities displayed by these aerial parts compared to fruits. This paper aims to review the current state of the art regarding the phenolic antioxidants from leaves and stems of two wild Vaccinium species, bilberry (Vaccinium myrtillus L.) and lingonberry (Vaccinium vitis-idaea L.), as promising natural resources with pharmaceutical and biological activity.

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Section: Anti-cancer Activitymentioning

confidence: 99%

Phenolic Antioxidants in Aerial Parts of Wild Vaccinium Species: Towards Pharmaceutical and Biological Properties

2019

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“…Cells seeded in 6-well plate were pre-treated for 4 h either with cyanidin-3-glucoside (C-3-Glu) (2, 10, and 20 µM; Cerilliant Corp., Round Rock, TX, USA) or various dilutions of lingonberry extract (1:1,000, 1:500, and 1:200). The lingonberry (LB) extract was prepared as previously described (23). After the pre-treatment, the cells were incubated for 4 h with palmitic acid (Sigma-Aldrich.…”

Section: Cell Culturementioning

confidence: 99%

“…Anthocyanins are a group of water soluble flavonoids known for their antioxidant, anti-inflammatory, and anticancer properties (22). Lingonberry contains three types of anthocyanins, identified as cyanidin-3-galactoside, cyanidin-3glucoside (C-3-Glu) and cyanidin-3-arabinoside (23). Among these, C-3-Glu is known to improve the redox status, energy, and glucose metabolism in rat kidneys (24).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Inflammatory Cytokine Expression Prevents High-Fat Diet-Induced Kidney Injury: Role of Lingonberry Supplementation

et al. 2020

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Chronic low-grade inflammation is a major stimulus for progression of chronic kidney disease (CKD) in individuals consuming high-fat diet. Currently, there are limited treatment options for CKD other than controlling the progression rate and its associated complications. Lingonberry (Vaccinium vitis-idaea L.) is rich in anthocyanins with demonstrated anti-inflammatory effect. In the current study, we investigated the potential renal protective effect of lingonberry and its anthocyanin (cyanidin-3-glucoside) in high-fat diet fed obese mice and in human proximal tubular cells. Prolonged consumption of high-fat diets is strongly associated with obesity, abnormal lipid and glucose metabolism. Mice (C57BL/6J) fed a high-fat diet (62% kcal fat) for 12 weeks developed renal injury as indicated by an elevation of blood urea nitrogen (BUN) level as well as an increase in renal kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL) and renin expression. Those mice displayed an activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and increased expression of inflammatory cytokines-monocyte chemoattractant-1 (MCP-1), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) in the kidneys. Mice fed a high-fat diet also had a significant elevation of inflammatory cytokine levels in the plasma. Dietary supplementation of lingonberry for 12 weeks not only attenuated high-fat diet-induced renal inflammatory response but also reduced kidney injury. Such a treatment improved plasma lipid and glucose profiles, reduced plasma inflammatory cytokine levels but did not affect body weight gain induced by high-fat diet feeding. Lingonberry extract or its active component cyanidin-3-glucoside effectively inhibited palmitic acid-induced NF-κB activation and inflammatory cytokine expression in proximal tubular cells. These results suggest that lingonberry supplementation can reduce inflammatory response and prevent chronic kidney injury. Such a renal protective effect by lingonberry and its active component may be mediated, in part, through NF-κB signaling pathway.

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“…The berries contain very high levels of anthocyanins, which are the red pigments that give all berries their bright red, blue, or purple colors (Penhallegon 2006). The three main anthocyanins in lingonberry are cyanidin-3-galactoside (C-3-Gal; 58% of all anthocyanins), cyanidin-3-arabinoside (C-3-Ara; 35%), and cyanidin-3-glucoside (C-3-Glu; 7%) (Dudonné 2015;Isaak et al 2015;Lee and Finn 2012). In addition to containing more anthocyanins per gram of fresh weight than other commonly consumed berries, lingonberry also contains other polyphenols, including quercetin glycosides, kaempferol glycosides, resveratrol, phenolic acids and proanthocyanidins (Bakowska-Barczak et al 2007;Grace et al 2014;Kalt et al 2008;Rimando et al 2004;Zheng and Wang 2003).…”

Section: R a F T Introductionmentioning

confidence: 99%

Lingonberry anthocyanins protect cardiac cells from oxidative-stress-induced apoptosis

Isaak

Petkau

Blewett

et al. 2017

Can. J. Physiol. Pharmacol.

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Lingonberry grown in northern Manitoba, Canada, contains exceptionally high levels of anthocyanins and other polyphenols. Previous studies from our lab have shown that lingonberry anthocyanins can protect H9c2 cells from ischemia-reperfusion injury and anthocyanin-rich diets have been shown to be associated with decreased cardiovascular disease and mortality. Oxidative stress can impair function and trigger apoptosis in cardiomyocytes. This study investigated the protective effects of physiologically relevant doses of lingonberry extracts and pure anthocyanins against hydrogen-peroxide-induced cell death. Apoptosis and necrosis were detected in H9c2 cells after hydrogen peroxide treatment via flow cytometry using FLICA 660 caspase 3/7 combined with YO-PRO-1 and then confirmed with Hoechst staining and fluorescence microscopy. Each of the 3 major anthocyanins found in lingonberry (cyanidin-3-galactoside, cyanidin-3-glucoside, and cyanidin-3-arabinoside) was protective against hydrogen-peroxide-induced apoptosis in H9c2 cells at 10 ng·mL (20 nmol·L) and restored the number of viable cells to match the control group. A combination of the 3 anthocyanins was also protective and a lingonberry extract tested at 3 concentrations produced a dose-dependent protective effect. Lingonberry anthocyanins protected cardiac cells from oxidative-stress-induced apoptosis and may have cardioprotective effects as a dietary modification.

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Manitoba Lingonberry (Vaccinium vitis-idaea) Bioactivities in Ischemia-Reperfusion Injury

Cited by 35 publications

References 44 publications

Phenolic Antioxidants in Aerial Parts of Wild Vaccinium Species: Towards Pharmaceutical and Biological Properties

Phenolic Antioxidants in Aerial Parts of Wild Vaccinium Species: Towards Pharmaceutical and Biological Properties

Inhibition of Inflammatory Cytokine Expression Prevents High-Fat Diet-Induced Kidney Injury: Role of Lingonberry Supplementation

Lingonberry anthocyanins protect cardiac cells from oxidative-stress-induced apoptosis

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