Mannan‐Binding Lectin in Children with Chronic Gastritis

Abstract

The involvement of mannan-binding lectin (MBL) insufficiency in the pathogenesis of chronic gastritis (CG) in children was investigated. Blood samples were collected from 78 paediatric patients suffering from CG associated with Helicobacter pylori infection (group Hp þ ) and from 41 with the disease not associated with such an infection (group Hp -). Control group consisted of 77 children. The frequency of mbl-2 gene mutations and serum protein concentrations did not differ significantly in both groups as compared with controls. An expression of mbl-2 gene in gastric biopsies of CG patients was demonstrated. It was found to be stronger in H. pylori-infected children. The results presented in this paper suggest that MBL deficit/dysfunction probably does not contribute to an increased risk of CG (both associated and not associated with H. pylori infection) in children. However, MBL opsonic effect and/or the lectin pathway of complement activation may be taken into account as possible host defence mechanisms in gastric patients.

Mannan-binding Lectin (MBL) Polymorphism and Gastric Cancer Risk in Japanese Population

“…The same genotype also seems to be associated with developing gastric cancer in patients 65 years of age or younger. Mannan-binding lectin is believed to play essential roles in H. pylori-induced gastritis [13] and carcinogenesis [14,15]. Our results may be partially explained by altered inflammatory responses in the gastric mucosa against H. pylori or by altered immune defenses against tumor progression.…”

“…Up-regulated mucosal expression of MBL has recently been reported in patients with H. pylori gastritis [13]. Two other recent publications report a possible association of MBL2 haplotype and susceptibility to H. pylori infection as well as the risk of gastric cancer [14,15].…”

Mannan-Binding Lectin (MBL) Deficient Individuals with the O/O Genotype are Highly Susceptible to Gastrointestinal Diseases

“…Previous studies have shown that the O allele is associated with a risk of developing more severe gastric mucosal atrophy and intestinal metaplasia in Helicobacter pylori infected individuals [51]. Other studies have shown that the O allele is not linked to chronic gastritis, dyspepsia, duodenal ulcer, ulcerative colitis (UC) and/or Chron's disease [52][53][54][55][56]. The cause behind the high gastrointestinal inflammatory symptoms among O/O genotypes in our study and the role of MBL in upper gastrointestinal immunity remains unclear.…”

Structure, Function, Molecular Genetics, Disease Associations and Therapeutic Potential of Mannose Binding Lectin: Review

“…82,83 Ya pı lan ça lış ma lar da H. pylo ri in fek si yo nu ne de niy le gas trit ge li şen has ta lar da gas trik mu koza da MBL eks pres yon ar tı şı nın ya nı sı ra, MBL2 geni birinci ek zon mu tant al lel le ri ve MBL2 hap lo tiple riy le, gas trik kan ser ge li şi mi ris ki ara sın da iliş ki bu lun du ğu bil di ril miş tir. [84][85][86] MBL ye ter siz li ği nin sis te mik lu pus eri te ma tozus' la (SLE) iliş ki si yo ğun bir şekil de ça lı şıl mak la bir lik te araş tır ma so nuç la rı uyum suz lık gös termek te dir. Son yıl lar da ya pıl mış ve 15 araş tır ma nın so nuç la rı nın ir de len di ği bir me ta-ana liz ça lış masın da MBL ek zon 1 ko don 54, pro mo tör -550 L ve pro mo tör -221 X mu tant al lel le ri nin SLE ge li şi mi için risk fak tö rü ol du ğu göz len miş tir.…”