Mannan-binding lectin polymorphisms and serum levels in patients with endometriosis

Kruse, Christina; Steffensen, Rudi; Nielsen, Hans Jørgen; Jensenius, Jens C.

doi:10.1016/j.ejogrb.2014.08.012

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Our results have also shown a higher level of MBL, which is the first component of lectin way. Our MBL results disagree with previously published studies, in which the concentration and total amount of peritoneal MBL does not differ in patients with and without endometriosis [ 21 ]. Moreover, there were no differences in the serum MBL levels in patients with or without endometriosis, which suggested that lectin could be involved in the modulation of inflammatory responses, but it did not seem to take part in endometriosis pathogenesis [ 22 , 23 ].…”

Section: Discussioncontrasting

confidence: 99%

“…Moreover, there were no differences in the serum MBL levels in patients with or without endometriosis, which suggested that lectin could be involved in the modulation of inflammatory responses, but it did not seem to take part in endometriosis pathogenesis [ 22 , 23 ]. Unfortunately, we do not have an explanation why there is such a difference in the MBL concentration in our results and the results of Kruse et al’s [ 21 ]. This may be related to the test used to measure the concentration or even the admixture of blood in the test sample.…”

Section: Discussioncontrasting

confidence: 99%

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The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis

Sikora

Wróblewska-Czech

Smycz‐Kubańska

et al. 2018

Arch Gynecol Obstet

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PurposeThe purpose of the work was to evaluate possible associations between the complement components C1q, mannose-binding lectin (MBL) and C1 inhibitor (C1INH) with pathogenesis of endometriosis.MethodsConcentrations of C1q, MBL and C1INH were measured by ELISA in peritoneal fluid (PF) in 80 women with or without endometriosis.ResultsSignificantly higher PF levels of C1q, MBL and C1INH in women with endometriosis compared to control group were observed (p < 0.0001). A higher concentration of the studied parameter was found in PF of women at the early stage of the disease, as compared to women with advanced endometriosis (p < 0.0001).ConclusionsOur research suggests that in the peritoneal cavity in women with endometriosis there are abnormal regulations of both the classical and lectin pathways of the complement system. This can suggest impairments in purification of peritoneal cavity from ectopic endometrial cells and augmented local inflammation in endometriosis patients.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis

Sikora

Wróblewska-Czech

Smycz‐Kubańska

et al. 2018

Arch Gynecol Obstet

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Insights into the role of complement system in the pathophysiology of endometriosis

2021

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The complement system and endometriosis: what's new?

Chizhova

Mangileva

Kudryavtseva

2023

Perm Medical Journal

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The objective of this literature review was to reveal new noninvasive markers of the complement system for improvement of endometriosis (EM) diagnostics. To analyze scientific literature, the international database was used. Among women with EM, a significant increase in the blood serum С1, С1-INH, C3c and С4 levels and elevated concentrations in the peritoneal fluid was observed. However, iC3b level in EM women was significantly lower in the peritoneal fluid and blood serum compared with healthy women. The levels of C4A/B gene expression were higher in the ectopic tissues than in the eutopic endometrium. The membrane attack complex (MAC) concentration was higher in the peritoneal fluid and blood serum among women with disseminated stage of EM compared to the control group. In women with EM, an increased level of mannose-binding lectin (MBL) in the peritoneal fluid was noted; a higher concentration was observed at the early stage of EM (stages I and II AFS) in comparison with the disseminated one (stages III and IV AFS). The development of new and improvement of the existing noninvasive markers of the complement system can be perspective for noninvasive diagnostics of EM and determination of the degree of its severity.

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Mannan-binding lectin polymorphisms and serum levels in patients with endometriosis

Cited by 3 publications

References 25 publications

The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis

The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis

Insights into the role of complement system in the pathophysiology of endometriosis

The complement system and endometriosis: what's new?

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