Mannan-oligosaccharides promote gut microecological recovery after antibiotic disturbance

Chen, Jing; Yin, Jialin; Xie, Heqiang; Lu, Wenwei; Wang, Hongchao; Zhao, Jianxin; Zhu, Jinlin

doi:10.1039/d4fo00332b

Food Funct.

2024

DOI: 10.1039/d4fo00332b

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Mannan-oligosaccharides promote gut microecological recovery after antibiotic disturbance

Jing Chen,

Jialin Yin,

Heqiang Xie

et al.

Abstract: This is the first study to examine the effect of Mannan-oligosaccharides (MOS) on promoting the growth of gut microbiota especially predictive recovery-associated bacterial species (p-RABs) and increasing SCFAs after short-term antibiotic treatment.

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Cited by 2 publications

References 56 publications

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Application of two crucial hemicellulolytic enzymes in fish diet: Xylanase and mannanase

yan Wang,

li Ding,

sheng Zhang

et al. 2025

Animal Feed Science and Technology

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Application of two crucial hemicellulolytic enzymes in fish diet: Xylanase and mannanase

yan Wang,

li Ding,

sheng Zhang

et al. 2025

Animal Feed Science and Technology

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Effects of Mannan-Oligosaccharides on Growth Performance, Serum Biochemical Indices, Immune Function, and Intestinal Morphology in Fattening Tan Sheep

Ma,

Jiang,

Zhao

et al. 2024

THE JAPS

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This study examined the effects of dietary Mannan-Oligosaccharides (MOS) on growth performance, serum biochemical indices, immune function, and intestinal morphology in fattening Tan sheep. Twenty-eight four-month-old male Tan sheep were assigned to four groups and received a basal diet supplemented with 0%, 1%, 2%, or 3% MOS for 56 days following a 14-day adaptation period.Results indicated that MOS supplementation significantly increased average daily gain (ADG) in a dose-dependent manner (P ≤ 0.05). Serum biochemical analyses showed a linear and quadratic reduction in triglyceride (TG) levels, and a linear and quadratic increase in alkaline phosphatase (ALP) levels (P ≤ 0.05). Total cholesterol (TC) levels decreased linearly, whereas urea nitrogen (UN) levels increased linearly with higher MOS levels (P ≤ 0.05). Mannan-Oligosaccharides also enhanced total antioxidant capacity (T-AOC) and catalase (CAT) activity, with both parameters increasing linearly (P ≤ 0.05). Immune function was significantly improved, demonstrated by elevated levels of immunoglobulin A (IgA), interleukin-6 (IL-6), IL-10, and interferon-gamma (IFN-γ) (P ≤ 0.05). Additionally, 2% and 3% MOS groups showed increased immunoglobulin G (IgG) and tumor necrosis factor-alpha (TNF-α) levels (P ≤ 0.05). Linear increases were noted in serum IgG, IgA, IgM, IL-6, and TNF-α levels, while IL-10 and IFN-γ levels exhibited both linear and quadratic increases (P ≤ 0.05).Intestinal morphology analysis revealed significant improvements in jejunal villus height, crypt depth reduction, and the villus-to-crypt ratio, with these parameters showing both linear and quadratic changes in response to increasing MOS levels (P ≤ 0.05). In conclusion, 2% MOS supplementation is recommended for enhanced growth performance, metabolic health, immune function, and intestinal integrity in fattening Tan sheep. Keywords: Tan sheep; growth performance; antioxidant; immune function; intestinal morphology

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Mannan-oligosaccharides promote gut microecological recovery after antibiotic disturbance

Abstract: This is the first study to examine the effect of Mannan-oligosaccharides (MOS) on promoting the growth of gut microbiota especially predictive recovery-associated bacterial species (p-RABs) and increasing SCFAs after short-term antibiotic treatment.

Cited by 2 publications

References 56 publications

Application of two crucial hemicellulolytic enzymes in fish diet: Xylanase and mannanase

Application of two crucial hemicellulolytic enzymes in fish diet: Xylanase and mannanase

Effects of Mannan-Oligosaccharides on Growth Performance, Serum Biochemical Indices, Immune Function, and Intestinal Morphology in Fattening Tan Sheep

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